Abstract: The present invention provides a nanoparticle dispersion for topical delivery to skin of a mammal. The nanoparticle dispersion includes: one or more hydrophobic bioactive agents or one or more hydrophobic drugs; one or more surfactants; one or more water immiscible oils; and water. Methods of preparing nanoparticles dispersions by hot melt extrusion are also provided.

Abstract: In variants, a device system can include a set of device parts that communicate using a response-request framework.

Abstract: An example method includes receiving, by one or more processing circuits, a registration request comprising an identifier and an activation gesture associated with a mobile application on a mobile device. The example method includes sending, by the one or more processing circuits to the mobile application on the mobile device, a notification indicating the mobile device is registered. The example method includes receiving, by the one or more processing circuits, a content item test request for content items in a specific content network. The example method includes testing, by the one or more processing circuits, the content items on the specific content network. The example method includes transmitting, by the one or more processing circuits to the mobile application on the mobile device, content event logs comprising debugging information of the content items during the testing on the content network.

Abstract: Systems, apparatus, methods and computer-readable storage media facilitating trusted pairing between an implantable medical device (IMD) and an external device are provided. In one embodiment, an IMD includes a housing configured to be implanted within a patient, a memory and circuitry within the housing and a processor that executes executable components stored in the memory.

Abstract: Systems, methods and computer-readable storage media can be used to debug content items. One example method includes presenting, by a mobile application executing on a mobile device, a first application interface. The example method further includes detecting, by the mobile device, a predetermined user action. The example method further includes, in response to detecting the predetermined user action, generating debugging information from content event logs, wherein the content event logs are associated with content item slots in which content items are presented in the mobile application and presenting, by a debugging interface, the debugging information.

Abstract: In variants, a fleet management method can include: determining information about a device; and sending information to the device, including authentication credentials, wherein the device can authenticate itself with other devices within the fleet using the authentication credentials. The fleet management system can function to scalably manage the operation and permissioning of one or more fleets of devices.

Abstract: A wastewater treatment system comprising a basin, an N2O sensor, and an organic carbon source. The basin is configured to subject wastewater to an activated sludge-based biological treatment wherein nitrogen is removed from the wastewater. The N2O sensor is positioned in the basin and configured to produce an N2O detection in the biological treatment. The organic carbon source is fluidly connected to the basin. The wastewater treatment system is configured to dose organic carbon from the organic carbon source to the biological treatment based on the N2O detection so that the wastewater treatment system controls an N2O level of the biological treatment via the organic carbon.

Abstract: An efficient nanoscale semiconducting optoelectronic system, containing a P/N acceptor donor organic hetrojunction which is optimized for neuronal stimulation—an organic electrolytic photocapacitor. The devices comprise a thin (80 nm) trilayer of metal and p-n semiconducting organic nanocrystals. When illuminated in physiological solution, these metal-semiconductor devices charge up, transducing light pulses into localized displacement currents that are strong enough to electrically stimulate neurons with safe light intensities.

Abstract: A thermal insulation assembly for a duct through which high temperature fluid, greater than 500 Fahrenheit, passes. The thermal insulation assembly can experience pressures less than 80 kilopascals and can be included in a turbine engine. The thermal insulation assembly includes a first foil layer confronting the duct, a second foil layer spaced from the first foil layer, an insulation layer between the first foil layer and the second foil layer, an opacifier layer provided on the insulation layer, and a reflective layer applied to the opacifier layer.

Abstract: In variants, a fleet management method can include determining information about a device S100; sending information to a device S200, and operating the device according to the information S300 (e.g., example shown in FIG. 1). The fleet management system can function to scalably manage the operation and permissioning of one or more fleets of devices.

Abstract: A medical device for use with a catheter assembly including an elongated catheter coaxially disposed within a sheath is disclosed. The medical device includes a deformable tube having a proximal end, a distal end, an outer wall with an outer diameter, and an inner wall forming an axial lumen. The distal end attaches to the sheath, and the proximal end receives the catheter into the lumen. The medical device also includes a opposing paddles disposed against the outer wall, each of the opposing paddles having a generally planar lock region to be disposed against outer wall at the outer diameter, the lock surface tangential to the deformable tube.

Abstract: A computer-implemented method for detecting anomalies in data from a sensor comprises receiving a plurality of data points from the sensor; determining a first anomaly score component, the first anomaly score component varying according to a Cook's Distance value; determining a second anomaly score component, the second anomaly score component varying according to a singular spectrum analysis value; determining a third anomaly score component, the third anomaly score component varying according to a rolling variance rate of change value; determining a fourth anomaly score component, the fourth anomaly score component varying according to whether a current data point is within an upper bound and a lower bound; determining a total anomaly score as a function of the anomaly score components; comparing the total anomaly score to an anomaly score threshold value; and determining the data point is an anomaly if the total anomaly score is greater than the threshold value.

Abstract: An approach is disclosed for assessing effectiveness of security information and event management (SIEM) environments. A rule status information with a number of used rules and a number of unused rules and a log source status with a number of active log sources and a number of inactive log sources is received from a threat detection insight (TDI) component by a production SIEM environment assessment report (SPEAR) tool. TDI performance scores and TDI quality scores are received from the TDI component for each used rule by the SPEAR tool. The SPEAR tool determines an availability score, a performance score, and a quality score from the rule status information, the log source status information, the TDI performance scores, and the TDI quality scores. The SPEAR tool determines a SPEAR from the availability score, the performance score, and the quality score.

Abstract: A surface cleaning apparatus is operable in a plurality of cleaning modes, including at least a wet cleaning mode and a dry vacuuming mode. The surface cleaning apparatus has a suction source, a suction inlet port in fluid communication with the suction source, a fluid dispenser, a pump in fluid communication with the fluid dispenser, a motor coupled with a brushroll to drive the brushroll, and a floor type sensor. Operating parameters of the apparatus may be automatically adjusted based on a detected floor type.

Abstract: A system for facilitating an ablation in a patient's heart is disclosed. The system includes a catheter and a controller. The catheter includes an electrode assembly having spaced-apart electrodes disposed on splines to generate an electric field in the heart, the splines configurable in an expanded position wherein the plurality of spaced-apart electrodes are in a selected spatial relationship, and wherein the splines are deformable relative to the expanded configuration when subjected to a force. The controller is configured to measure an electrical signal received from an electrode of the spaced-apart electrodes in response to the electric field, the electrical signal indicative of a parameter of the electric field, and the controller configured to determine a deformation of the splines relative to the expanded position based on the measured electrical signal.

Abstract: A system for performing electroporation ablation of target tissue in a chamber of a patient's heart is disclosed. The system including a catheter including an electrode assembly having a plurality of electrodes, wherein the catheter is adapted to position the electrode assembly at a plurality of locations proximate the target tissue, a graphical display, and a controller. The controller configured to generate, on the graphical display, a graphical representation of the electrode assembly. The controller configured to generate, on the graphical display, a graphical representation of a model of electric fields generated in response to delivery of pulsed electrical signals to selected ones of the plurality of electrodes.

Abstract: Disclosed herein are salts of the compound of Formula (I) and polymorphs thereof, methods of making the same, and their methods of use in treating eye diseases and disorders, particularly those associated with inflammation and/or vascular proliferation in subjects. The methods include administering therapeutically effective amounts of salts of the compound of Formula (I) and polymorphic forms thereof, to a subject in need thereof.

Abstract: An autonomous vacuum cleaner includes an autonomously moveable housing carrying a vacuum collection system for generating a working air flow for removing dirt from the surface to be cleaned and storing the dirt in a collection space. Distance sensors for position sensing are mounted to the housing. The distance sensors can be staggered and/or positioned on one or more sides or above a brush chamber for a brushroll.

Abstract: A computer system receives a freight request from a shipper, where the freight request specifies a destination for a load of the shipper. The computer system implements a selection process to select a freight operator to haul a corresponding trailer of the trailer module from a location of the shipper to a destination. The trailer module may be monitored using information transmitted from the trailer, to determine when the trailer is picked up and/or delivered at the destination.

Abstract: Improved inspection techniques are described herein for checking for the presence of and identifying surface defects on a honeycomb body. The improved inspection utilizes measurement of travel of an outer surface of the honeycomb body to collect images of the outer surface. The images are combined into a composite image showing the outer surface of the honeycomb body. The composite image is analyzed to identify surface defects.