Patent number: 6329383
Abstract: The present invention relates to new benzimidazole compounds with the following general structure (I):
in which
Y—X is >C═X when X is NR8, O, or S and R2 is H, alkyl, substituted alkylaryl or substituted aryl; or
Y—X is >C—X when X is H, alkyl, substituted alkyl, aryl, substituted aryl, OR9 or NHR9 and R2 is a bond to Y;
Z is O, S or NR12;
R1 is H, alkyl, substituted alkyl, aryl or substituted aryl;
R3 is H, alkyl, substituted alkyl, aryl or substituted aryl, OR9 or NHR9;
R4, R5, R6 and R7 are H, halogen, OR10, NR10, R11, NO2, CF3, CN, COR8, COOR8, CONHR8 and/or N3 in any combination and/or two adjacent R4, R5, R6 or R7 form a carbocyclic or heterocyclic ring; and
R8, R9, R10, R11, R12 and R13 are H, alkyl, substituted alkylaryl, aryl and/or substituted aryl in any combination.
These compounds are useful as a human Growth Hormone (hGH) mimetic, which trigger GH agonist effects in animals and especially as an orally available human Growth Hormone (hGH).
Type:
Grant
Filed:
January 24, 2000
Date of Patent:
December 11, 2001
Assignee:
Pharmacia AB
Inventors:
Charles Hedgecock, Eric Desarbre, Guido Kurz, Martin Norin, Marguerite Luthman, Cathrin Widerståhl