Abstract: A modular multi-zone mattress and related method of design for which a plurality of mattress modules are adjoined to define a sleep surface having a variable deformability. A number of the mattress modules and a deformability of each mattress module are tailored to a unique body shape and weight distribution of a mattress user to provide at least one of an optimized body posture and an optimized contact pressure distribution over the sleep surface. Pressure factors include a weight and a morphologic profile of the mattress user, and optionally, a sleep position of the mattress user.

Abstract: Disclosed are processes and techniques implementable by a drug delivery system to maintain optimal drug delivery for a patient according to a treatment plan. The disclosed techniques enable a new drug delivery device that is exchanged for a previous drug delivery device to operate using analyte-based drug delivery control immediately during initialization instead of having to wait for a warm-up period. For example, a drug delivery device may include a processor and a memory storing instructions that, when executed by the processor, operate the drug delivery device to receive a present analyte measurement value from an analyte sensor during an initialization of the drug delivery device, receive backfill values measured by the analyte sensor prior to the initialization, calculate a dosage of a drug using the present analyte measurement value and the backfill values, and deliver the dosage of the drug. Other embodiments are described.

Abstract: A drug delivery device including a reservoir operable to contain a liquid drug, a fluid outlet including an outlet reservoir opening and an outlet fluid channel, wherein the outlet reservoir opening has a volume and is fluidly coupled to the outlet fluid channel, and an outlet filter plug operable to fill the volume of the outlet reservoir opening and collect particulate material as the liquid drug is expelled from the reservoir.

Abstract: Exemplary embodiments may provide a medicament delivery device that includes a single instrument for piercing the skin of the user and for acting as a conduit for delivering medicament to the user subcutaneously. The exemplary embodiments may reduce discomfort caused by a rigid cannula or needle. The exemplary embodiments may provide instruments that are configured to be comfortable to the user when the instruments are in place beneath the skin of the user, such as when a medicament delivery device is delivering medicament to the user.

Abstract: Disclosed herein is a combination of an automated insulin delivery system and a continuous glucose monitor integrated into a single, wearable package. The system may use any combination of delivery methods and detection methods, wherein the delivery methods include a cannula, a microneedle array, and a transdermal patch, and wherein the detection methods include electrochemical methods, opto-fluorescent methods, and spectrographic methods.

Abstract: A modular multi-zone mattress and related method of design for which a plurality of mattress modules are adjoined to define a sleep surface having a variable deformability. A number of the mattress modules and a deformability of each mattress module are tailored to a unique body shape and weight distribution of a mattress user to provide at least one of an optimized body posture and an optimized contact pressure distribution over the sleep surface. Pressure factors include a weight and a morphologic profile of the mattress user, and optionally, a sleep position of the mattress user.