Patents by Inventor Eric E. Bruening

Eric E. Bruening has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR GENERATING AND AMPLIFYING DNA LIBRARIES FOR SENSITIVE DETECTION AND ANALYSIS OF DNA METHYLATION
    Publication number: 20180030527
    Abstract: The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries.
    Type: Application
    Filed: June 12, 2017
    Publication date: February 1, 2018
    Inventors: Vladimir L. MAKAROV, Emmanuel KAMBEROV, Tong SUN, Jonathan H. PINTER, Brendan J. TARRIER, Eric E. BRUENING, Takao KURIHARA, Tim TESMER, Joseph M'Mwirichia
  • HIV Vaccines Comprising One or More Population Episensus Antigens
    Publication number: 20170319679
    Abstract: Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1 vaccines comprising a carrier, a population episensus antigen, and a tailored antigen. Also provided are methods of designing and producing an HIV-1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach, and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences, producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. Further provided are methods of treating HIV-1 in a subject comprising administering an effective amount of the described HIV-1 vaccines to the subject in need thereof.
    Type: Application
    Filed: October 5, 2015
    Publication date: November 9, 2017
    Applicant: Vir Biotechnology, Inc.
    Inventors: Eric E. BRUENING, Klaus FRUEH, Louis PICKER, Bette T. KORBER, James THEILER, Emily MARSHALL
  • Methods and compositions for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation
    Patent number: 9708652
    Abstract: The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: July 18, 2017
    Assignee: RUBICON GENOMICS, INC.
    Inventors: Vladimir L. Makarov, Emmanuel Kamberov, Tong Sun, Jonathan H. Pinter, Brendan J. Tarrier, Eric E. Bruening, Takao Kurihara, Tim Tesmer, Joseph M'Mwirichia
  • Methods and compositions for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation
    Patent number: 8440404
    Abstract: The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: May 14, 2013
    Assignee: Rubicon Genomics
    Inventors: Vladimir L. Makarov, Emmanuel Kamberov, Tong Sun, Jonathon H. Pinter, Brendan J. Tarrier, Eric E. Bruening, Takao Kurihara, Tim Tesmer, Joseph M'Mwirichia