Patents by Inventor Eric Edward Swayze

Eric Edward Swayze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANS-CYCLOOCTENE LABELED ANTISENSE OLIGONUCLEOTIDES, RADIO LABELED TETRAZINE AND METHODS
    Publication number: 20220290140
    Abstract: Featured are trans-cyclooctene and tetrazine compounds. Also provided are methods for evaluating the biodistribution and/or concentration of a biomolecule in a subject.
    Type: Application
    Filed: August 19, 2020
    Publication date: September 15, 2022
    Inventors: Brendon Ellery COOK, Maciej Adam KALISZCZAK, Laurent MARTARELLO, Nathan Edward GENUNG, Sivaraman DANDAPANI, Eric Edward SWAYZE, William John DRURY, III, Chrissa Ann DWYER
  • Amine compounds and combinatorial libraries comprising same
    Patent number: 6750344
    Abstract: The present invention provides monocyclic, bicyclic and oligomeric amine compounds with at least two sites of diversity. These compounds are formed from monocyclic scaffolds which can be cyclized to form bicyclic amine scaffolds. These can then be reacted with building blocks to form the amine compounds of the invention. This invention further provides libraries or monocyclic, bicyclic and oligomeric amine compounds. Also provided are methods for preparing monocyclic, bicyclic and oligomeric amine compounds and libraries thereof. The present invention also provides pharmaceutical compositions of the monocyclic, bicyclic and oligomeric amine compounds.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: June 15, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Eric Edward Swayze, Peter William Davis, Robert Jay Tinder, Kelly G. Sprankle
  • Macrocyclic compounds and preparation methods thereof
    Patent number: 6660832
    Abstract: The present invention is directed to macrocyclic compounds of the formula (I) wherein Q, X, R1 and R5 are as defined herein. Compounds of the invention are useful for therapeutic and prophylactic treatment of bacterial infection in mammals. Solid phase synthetic procedures are provided effecting synthesis of the macrocyclic rings attached to a solid support.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: December 9, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Elizabeth Jefferson, Eric Edward Swayze
  • Amide compound libraries
    Patent number: 6359061
    Abstract: Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: March 19, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Eric Edward Swayze, Peter William Davis
  • Amine compounds and combinatorial libraries comprising same
    Patent number: 6316626
    Abstract: The present invention provides monocyclic, bicyclic and oligomeric amine compounds with at least two sites of diversity. These compounds are formed from monocyclic scaffolds which can be cyclized to form bicyclic amine scaffolds. These can then be reacted with building blocks to form the amine compounds of the invention. This invention further provides libraries or monocyclic, bicyclic and oligomeric amine compounds. Also provided are methods for preparing monocyclic, bicyclic and oligomeric amine compounds and libraries thereof. The present invention also provides pharmaceutical compositions of the monocyclic, bicyclic and oligomeric amine compounds.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: November 13, 2001
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Eric Edward Swayze, Kelly G. Sprankle
  • Ethylenediamine compound libraries
    Patent number: 6316623
    Abstract: Libraries of ethylenediamine compounds having the general formula (I): wherein R1 to R6, m, n, o and p are as defined herein, are prepared using solid phase combinatorial chemistry techniques. A heterocyclic alcohol is reacted with an ethylenediamine bound to a solid support to give a scaffold having sites of diversity. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: November 13, 2001
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Eric Edward Swayze, Elizabeth Anne Campbell Jefferson