Abstract: A method, according to some implementations, includes obtaining trial design simulation results for a set of trial designs and determining a set of Pareto designs in the set of trial designs based at least in part on the trial design simulation results and one or more performance parameters. The method further includes determining a set of convex hull designs in the set of trial designs, determining a set of recommended designs based at least in part on the set of Pareto designs and the set of convex hull designs, and transmitting the set of recommended designs.

Abstract: The disclosure describes techniques for configuring wireless routers of a wireless mesh network with one or more secondary wireless access points (WAPs) such that client devices connected to the mesh network may remain online in the event that a primary WAP goes offline or otherwise becomes unavailable. For instance, a user of the wireless mesh network may specify a device, such as a mobile electronic device connected to a cellular network, to operate as a secondary WAP in the event that a primary WAP becomes unavailable. Thereafter, upon a wireless router of the mesh network detecting that the primary WAP is unavailable, the wireless router may perform a network scan to identify SSID(s) that are available within the environment. The wireless router may also instruct the other routers of the mesh network to perform a network scan.

Abstract: A method for searching clinical trial designs that includes: determining a first convex hull set from a first set of clinical trial designs for a first scenario; simulating the first convex hull set for a second scenario to determine first simulation results; removing the first convex hull set from the first set of clinical trial designs to generate a second set of clinical trial designs; determining a second convex hull set from the second set of clinical trial designs for the first scenario; simulating the second convex hull set for the second scenario to determine second simulation results; determining, based at least in part on the first simulation results and the second simulation results, a refined scenario convex hull set of clinical trial designs for the second scenario from the first convex hull set and the second convex hull set; and transmitting the refined scenario convex hull set.

Abstract: This invention relates to, among other items, treating Alzheimer's disease by administering epetraborole, or a salt, hydrate or solvate thereof, to a patient in need of treatment thereof.

Abstract: A build unit for additively manufacturing three-dimensional objects may include an energy beam system having one or more irradiation devices respectively configured to direct one or more energy beams onto a region of a powder bed, and an inertization system including an irradiation chamber defining an irradiation plenum, one or more supply manifolds, and a return manifold. The one or more supply manifolds may include a downflow manifold configured to provide a downward flow of a process gas through at least a portion of the irradiation plenum, and/or a crossflow manifold configured to provide a lateral flow of the process gas through at least a portion of the irradiation plenum. The return manifold may evacuate process gas from the irradiation plenum. While irradiating the region of the powder bed, the process gas may flow through the one or more supply manifolds, into the irradiation plenum, and into the return manifold.

Abstract: A method for determining trial designs is provided. The method includes receiving, via at least one processor, one or more trial design criteria and one or more scenarios corresponding to a set of trial designs, and generating, via the at least one processor, simulation data based at least in part on replicating each of the set of trial designs with the one or more trial design criteria and the one or more scenarios. The simulation data includes performance parameters and performance parameter values associated with each design in the set of designs for a set of criteria. The method further includes determining, via the at least one processor, an optimality criteria for evaluating the trial designs, searching, within the set of trial designs, via the at least one processor, for globally optimum designs based on the optimality criteria, and transmitting, via the at least one processor, globally optimum designs.

Abstract: Protecting sensitive data from unauthorized disclosure is provided. For example, systems, methods, and computer readable storage devices are described that may be operable or configured to tokenize sensitive data attributes that may be included in a data file received from a client. Tokens that are anonymized but representative of the attributes may be generated and mapped to the sensitive data attributes. A tokenized data file may be de-tokenized and re-tokenized to perform processes that require the sensitive data attributes. A document may be transformed to protect the sensitive data attributes while reducing risk of disclosure of the sensitive data.

Abstract: A three dimensional representation of sports data from multiple sources, which has A) a computer program stored on a non-transitory computer readable medium, B) a server operatively associated with the non-transitory computer readable medium, C) a computer vision model using feature detection algorithms, D) a database associated to the computer vision model, E) data to upload to the database, F) a graphical user interface to show data, and G) a computer device, whereby users access to the graphical user interface to upload and visualize the data. The data is visually shown through two-dimension and three-dimension images, text, numbers, animations, and custom visuals to allow the users to analyze the data.

Abstract: A method of aligning at least one laser beam of an additive manufacturing arrangement. The method includes measuring a surface of the calibration plate at a plurality of measurement points using the coordinate measuring machine. The method further includes generating a correction field based on the plurality of measurement points using the coordinate measuring machine. The method further includes writing at least one fiducial mark on the surface of the calibration plate using the at least one laser beam. The method further includes generating calibration data for the surface of the calibration plate using the calibration system. The method also includes aligning the laser beam within the additive manufacturing system based on the calibration data and the correction field using the computing device by comparing a position of the fiducial mark from the calibration data with the correction field to determine a corrected position of the laser beam.

Abstract: A command measurement system employs a ball flight tracking system that measures the location of a ball as it breaks the plane of the strike zone. The command measurement system also employs an intended pitch location system that provides the pitcher with a wireless signal to inform the pitcher of the intended pitch location. This intended pitch location target forms the pitcher's intent of where he or she is trying to pitch the ball. The measured pitch location is compared to the intended pitch location and a measure of command is determined by the amount of deviation of the measured location from the intended pitch location.

Abstract: A method for trial design includes presenting on a graphical interface, a set of cards, wherein each card in the set is representative of a different trial design from a set of trial designs. The method further includes: monitoring a first set of user interactions with the set of cards; determining a user preference for one or more values of one or more parameters of the set of trial designs from the first set of user interactions; and presenting on the graphical interface a new card that is representative of a trial design consistent with the determined user preference. The method may also include monitoring a second set of user interactions with the new card and refining the determined user preference based at least in part on the second set of user interactions with the new card.

Abstract: Systems and methods are provided for implementing encryption of data-in-motion and/or otherwise stored data using a key server and a secure enclave of a Network Interface Card (NIC). The NIC acts as a passthrough between the client device and the shared infrastructure of the supercomputer system to help ensure data security in a massively scaled and distributed system. For example, in response to an enrollment process that stores a decrypted key in the secure enclave of a NIC, the NIC can receive a data packet from a client device. The NIC can transmit a key request to a key server that includes an encrypted key corresponding to the decrypted key. The key server can look up the previously stored private/public key pair to authenticate the NIC. The key server can provide private/public key pair to the NIC to allow the NIC to later encrypt data-in-motion.

Abstract: A method for determining trial designs is provided. The method includes receiving, via at least one processor, one or more trial design criteria and one or more scenarios corresponding to a set of trial designs, and generating, via the at least one processor, simulation data based at least in part on replicating each of the set of trial designs with the one or more trial design criteria and the one or more scenarios. The simulation data includes performance parameters and performance parameter values associated with each design in the set of designs for a set of criteria. The method further includes determining, via the at least one processor, an optimality criteria for evaluating the trial designs, searching, within the set of trial designs, via the at least one processor, for globally optimum designs based on the optimality criteria, and transmitting, via the at least one processor, globally optimum designs.

Abstract: A build unit for additively manufacturing three-dimensional objects may include an energy beam system, an irradiation chamber, an inertization system having a return manifold configured to evacuate a process gas from the irradiation chamber. The return manifold includes a plurality of return manifold bodies and return manifold inlet disposed at a bottom of the irradiation chamber. The plurality of return manifold bodies includes one or more return manifold pathways downstream of the return manifold inlet. The plurality of return manifold bodies also includes one or more recapture pathways positioned to receive the process gas into the one or more return manifold pathways that flows past the return manifold inlet.

Abstract: A build unit for additively manufacturing three-dimensional objects may include an energy beam system having one or more irradiation devices respectively configured to direct one or more energy beams onto a region of a powder bed, and an inertization system including an irradiation chamber defining an irradiation plenum, one or more supply manifolds, and a return manifold. The one or more supply manifolds may include a downflow manifold configured to provide a downward flow of a process gas through at least a portion of the irradiation plenum defined by the irradiation chamber, and/or a crossflow manifold configured to provide a lateral flow of the process gas through at least a portion of the irradiation plenum defined by the irradiation chamber. The return manifold may evacuate or otherwise remove process gas from the irradiation plenum defined by the irradiation chamber.

Abstract: In accordance with a version, one or more identification clips, identification clip systems, and methods are provided which safely attach to and identify a plurality of damaged shingles to visually demonstrate and ascertain the extent of roof damage from a distance, particularly from the perspective of someone standing on the ground.

Abstract: A waste extraction system includes a precipitation tank comprising a waste stream input, a solution input, and a waste stream output, wherein the waste stream input is fluidly coupled to an upstream segment of a main waste pathway, a column effluent tank, an adsorption column positioned between and fluidly coupled to the precipitation tank and the column effluent tank along the main waste pathway, wherein the adsorption column houses an ion exchange resin and is positioned downstream the precipitation tank, a solution pathway extending from a solution source to the solution input of the precipitation tank, the solution source housing an alkaline solution, and a particle filtration unit positioned between and fluidly coupled to the precipitation tank and the adsorption column.

Abstract: A system, method, and computer readable and executable media for detecting, alerting, managing, and optionally mitigating cyber security events on an aircraft's networks using an on-board cyber security appliance and applications that monitors and detects cyber security events in real time. A software selectable cyber security agent within the cyber security appliance mitigates (if enabled) the effects of a cyber security events and/or anomalies on the aircrafts networks while the aircraft is in-flight and/or on the ground.

Abstract: A fabrication device includes a build surface to receive layers of material for production of a 3-dimensional solid representation of a digital model and an imaging component to bind respective portions of the build material into cross sections representative of portions of data contained in the digital model. The device can include a system to recirculate and/or homogenize material prior to use in the fabrication process. The device can include a system for controlling the density of the printed part. An exemplary object made by the fabrication device can include a powder composite component using any of a variety of powder materials. The exemplary object can be further post-processed to produce a high precision metal or ceramic component. The fabrication device can include a selective deposition unit for selectively depositing a supplemental build material at high resolution. The fabrication device can include an imaging unit with extended usage life.