Patents by Inventor ERIC ESCOBAR CABRERA

ERIC ESCOBAR CABRERA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies with Enhanced or Suppressed Effector Function
    Publication number: 20130089541
    Abstract: Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
    Type: Application
    Filed: March 28, 2011
    Publication date: April 11, 2013
    Applicant: ZYMEWORKS INC
    Inventors: Igor D'Angelo, Dustin Bleile, Stacey A.L. Tom-Yew, Eric Escobar-Cabrera, Paula I. Lario, Anders Ohrn, David K.Y Poon, Surjit B. Dixit
  • Stable Heterodimeric Antibody Design with Mutations in the Fc Domain
    Publication number: 20120149876
    Abstract: The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.
    Type: Application
    Filed: November 4, 2011
    Publication date: June 14, 2012
    Applicant: ZYMEWORKS INC.
    Inventors: THOMAS SPRETER VON KREUDENSTEIN, ERIC ESCOBAR CABRERA, SURJIT BHIMARAO DIXIT, PAULA IRENE LARIO, DAVID KAI YUEN POON, IGOR EDMONDO PAOLO D'ANGELO