Patents by Inventor Eric Falcone

Eric Falcone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALKALINE PHOSPHATASE POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20240382568
    Abstract: Featured are pharmaceutical compositions that include a soluble alkaline phosphatase for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).
    Type: Application
    Filed: August 7, 2024
    Publication date: November 21, 2024
    Inventors: Walter C. VOEGTLI, Yuhong WU, Jonathan MONTELEONE, Tatyana MEZHEBOVSKY, Eric FALCONE, Yang GUO
  • Alkaline phosphatase polypeptides and methods of use thereof
    Patent number: 12083169
    Abstract: Featured are pharmaceutical compositions that include a soluble alkaline phosphatase for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).
    Type: Grant
    Filed: February 10, 2022
    Date of Patent: September 10, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Walter C. Voegtli, Yuhong Wu, Jonathan Monteleone, Tatyana Mezhebovsky, Eric Falcone, Yang Guo
  • ALKALINE PHOSPHATASE POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20220265784
    Abstract: Featured are pharmaceutical compositions that include a soluble alkaline phosphatase for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).
    Type: Application
    Filed: February 10, 2022
    Publication date: August 25, 2022
    Inventors: Walter C. VOEGTLI, Yuhong WU, Jonathan MONTELEONE, Tatyana MEZHEBOVSKY, Eric FALCONE, Yang GUO
  • Squarylated lactones inhibitors for bacterial biofilm formation
    Patent number: 8940911
    Abstract: A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 ?M), these small molecules inhibit biofilm formation of E. coli. Moreover, these compounds are not toxic up to 300 ?M and do not significantly attenuate E. coli growth. The SHLs have potential to disperse established biofilm and demonstrate an enhanced reduction (˜50%) of the maximum biofilm thickness by use of SHLs during biofilm growth.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: January 27, 2015
    Assignee: Syracuse University
    Inventors: Yan-Yeung Luk, Sri Kamesh Narasimhan, Eric Falcone
  • Squarylated Lactones Inhibitors for Bacterial Biofilm Formation
    Publication number: 20140039195
    Abstract: A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (˜200 ?M), these small molecules inhibit biofilm formation of E. coli. Moreover, these compounds are not toxic up to 300 ?M and do not significantly attenuate E. coli growth. The SHLs have potential to disperse established biofilm and demonstrate an enhanced reduction (˜50%) of the maximum biofilm thickness by use of SHLs during biofilm growth.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 6, 2014
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Yan-Yeung Luk, Sri Kamesh Narasimhan, Eric Falcone