Abstract: Provided are, inter alia, flow centration components that can be used in flow cytometers and other applications. A flow centrator can define central axis, a proximal end, and a distal end, and having a central bore extending within the flow centration component in the direction of the central axis; the flow centration component defining a splined outer surface that defines a plurality of circumferentially arranged bypass flute channels, the plurality of bypass flute channels extending in the direction of the central axis, and each of the bypass flute channels having a depth and a length. Also provided are related methods that utilize the disclosed components.

Abstract: Provided are, inter alia, flow centration components that can be used in flow cytometers and other applications. A flow centrator can define central axis, a proximal end, and a distal end, and having a central bore extending within the flow centration component in the direction of the central axis; the flow centration component defining a splined outer surface that defines a plurality of circumferentially arranged bypass flute channels, the plurality of bypass flute channels extending in the direction of the central axis, and each of the bypass flute channels having a depth and a length. Also provided are related methods that utilize the disclosed components.

Abstract: Provided are handling systems and methods for sample processing. The systems can include a sample container and a probe. A system can be convertible between a loading state in which a user loads sample into the sample container, a sampling state in which relative motion between the sample container and the probe places the probe and sample container into fluid communication with one another so that the probe can aspirate sample from the sample container, and a washing state in which rinse fluid is expressed through the probe so as to remove unwanted material from within the probe, with the rinse fluid being collected by a wash manifold.