Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low error rate, low phasing rate, or increased incorporation rate for a second generation ffN under reduced incorporation times, as well as methods and kits using the same.

Abstract: A removable hot box is disclosed that includes a lower hot box portion, comprising: a lower housing comprising a plurality of lower clamping structures to clamp the lower housing to a press and locating structures to provide repeatable placing in the press; and a lower heating platen, received within the lower housing, wherein the lower housing or the lower heating platen comprises lower electrical connectors to provide a lower electrical connection to a heating system and lower cooling connectors to provide a lower cooling connection to a cooling system; and an upper hot box portion, positionable above the lower hot box portion and comprising: an upper housing comprising a plurality of upper clamping structures to clamp the upper housing to the press; an upper heating platen, received within the upper housing.

Abstract: A virtual surgical robot being built from kinematic data is rendered to a display. A user input is received to effect a movement or a configuration of the virtual surgical robot. The kinematic data is modified based on evaluation of the movement or the configuration of the virtual surgical robot.

Abstract: A turbomachine includes a housing assembly having a first housing member with a shroud surface, a bearing housing, and a second housing member. The turbomachine further includes a bearing that supports rotation of a rotating group within the housing assembly. The first housing member has a first axial surface and the bearing housing has a second axial surface that is substantially flush with the first axial surface. The second housing member has a third axial surface facing in an axial direction opposite that of the first and second axial surfaces. The first housing member has a first radial surface and the bearing housing has a second radial surface. The first housing member and the bearing housing are attached to the second housing member. The first and second axial surfaces abut against the third axial surface, and the first radial surface abutting against the second radial surface.

Abstract: The present invention relates to a hygroscopic matrix based composition, a process for the preparation thereof and its use in the treatment of diseases.

Abstract: The present invention relates to a hygroscopic matrix based composition, a process for the preparation thereof and its use in the treatment of diseases.

Abstract: A system and method for ranking content creators are described. The method for ranking content creators may comprises collecting endorsements associated with a content creator; qualifying the authors of the endorsements; building a creator network, applying an endorsement weighting function to the endorsements; assigning a score to the content creators; and ordering a collection of content items based on the items' assigned score. The identities of content creators are verified by matching content creators in a database to a publicly available online profile. Creators are entered into a creator network consisting of an edges and nodes graph and a weighting function is applied, resulting in a fixed-point score for each creator in the network. These fixed-point scores are inherited by content items produced by the creators and may be used to order a collection of content items pulled from a database.

Abstract: Method for preparing eplivanserin hemifumarate.

Abstract: The present invention relates to a method for the preparation of pharmaceutical compositions in the form of tablets with improved drug substance dispersibility, which method comprises a) preparing a dispersion of at least one pharmaceutically active drug substance and at least one surfactant and/or binder in a liquid; b) preparing a carrier by dry blending at least one porous carrier and one or more excipient(s); and c) spray granulating the dispersion prepared in step a) onto the carrier prepared in step b) to obtain a spray-granulated product.

Abstract: Techniques involving messaging applications are disclosed. For example, an apparatus may include a presence determination module and a publication module. The presence determination module may infer one or more presence indicators regarding a user. These inference(s) may be based on sensor data. In addition, these inference(s) may be based on position information, and device activity data. The publication module publishes the one or more presence indicators to a messaging server. These presence indicator(s) may indicate an activity and/or a location context of the user.

Abstract: A circuit (26) performs a discrete Walsh transform using a reduced set of arithmetic operators. The circuit (26) comprises a first memory component (32), an adder (36), a subtractor (38), a second memory component (40), and a controller (52). In each of a plurality of stages, the controller (52) enables the first memory component (32) to communicate each of a plurality of pairs of values stored therein to the adder (36) and to the subtractor (38). The controller (52) enables the second memory component (40) to store each of a plurality of results from the adder (36) and the subtractor (38) and to communicate the stored results to the first memory component (32) for use in a subsequent stage.

Abstract: The present invention relates to a method for the preparation of pharmaceutical compositions in the form of tablets with improved drug substance dispersibility, which method comprises a) preparing a dispersion of at least one pharmaceutically active drug substance and at least one surfactant and/or binder in a liquid; b) preparing a carrier by dry blending at least one porous carrier and one or more excipient(s); and c) spray granulating the dispersion prepared in step a) onto the carrier prepared in step b) to obtain a spray-granulated product.

Abstract: Embodiments of the present invention include an apparatus for handling a work piece. The apparatus comprises a rigid frame having an interior perimeter and an exterior perimeter, wherein the interior perimeter comprises a plurality of mounts. The apparatus further includes a plurality of retention springs coupled to the plurality of mounts, the retention springs for applying a retention force on the work piece to prevent movement between the work piece and the interior perimeter of the rigid frame. The apparatus further includes an actuating mechanism for simultaneously actuating each of the plurality of retention springs from an open position to a closed position.