Patents by Inventor Eric Gouaux

Eric Gouaux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GluR2 receptor modulators
    Publication number: 20090270508
    Abstract: The present invention provides for compositions and methods for modulating the GluR2 receptor. It is based, at least in part, on the discovery, by X-ray crystallography, that a known GluR2 agonist binds to the receptor in two different orientations, thereby diminishing its potency. The present invention provides for structural alternatives in which alternative binding possibilities are substantially eliminated.
    Type: Application
    Filed: January 30, 2009
    Publication date: October 29, 2009
    Inventors: James Eric Gouaux, Langzhou Song, Yuli Xie, Donald W. Landry
  • Vectors And Methods For Identifying Proteins Amenable To Crystallization
    Publication number: 20090104645
    Abstract: The present invention provides for methods, systems and materials that may be used to identify and select proteins that are amenable to crystallization. While previous methods of screening proteins for crystallization required at least microgram quantities of purified protein, the inventive method can be practiced using nanogram quantities of unpurified protein.
    Type: Application
    Filed: August 7, 2008
    Publication date: April 23, 2009
    Applicant: The Trustees Of Columbia University In The City Of New York
    Inventors: James Eric Gouaux, Toshimitsu Kawate
  • GLU2 RECEPTOR MODULATORS
    Publication number: 20070293573
    Abstract: The present invention provides for compositions and methods for modulating the GluR2 receptor. It is based, at least in part, on the discovery, by X-ray crystallography, that a known GluR2 agonist binds to the receptor in two different orientations, thereby diminishing its potency. The present invention provides for structural alternatives in which alternative binding possibilities are substantially eliminated.
    Type: Application
    Filed: February 23, 2007
    Publication date: December 20, 2007
    Inventors: ERIC GOUAUX, Langzhou SONG, Yuli XIE, Donald LANDRY
  • Designed protein pores as components for biosensors
    Publication number: 20050131211
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Application
    Filed: September 21, 2004
    Publication date: June 16, 2005
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux
  • Designed protein pores as components for biosensors
    Patent number: 6824659
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: November 30, 2004
    Assignee: University of Massachusetts
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux
  • DESIGNED PROTEIN PORES AS COMPONENTS FOR BIOSENSORS
    Publication number: 20040191845
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Application
    Filed: February 15, 2001
    Publication date: September 30, 2004
    Applicant: United States of America, as Represented by the Secrectary of Commerce
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux