Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: Embodiments of the present disclosure may comprise an adapter to couple a wire to a solder joint, with the adapter comprising a solder joint receiving hole and a wire attachment terminal.

Abstract: Embodiments of the present disclosure may comprise an adapter to couple a wire to a solder joint, with the adapter comprising a solder joint receiving hole and a wire attachment terminal.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: The present disclosure relates to the use of UNC13A cryptic exon splice variant specific inhibitors for methods of reducing expression of a UNC13A cryptic exon splice variant in a cell, reducing phosphorylated TAR-DNA binding protein-43 (TDP-43) in a cell, treating TAR-DNA binding protein-43 (TDP-43) proteinopathy in a subject, or treating a subject has been identified as having a UNC13A mutation in intron 20-21 of UNC13A. Antisense oligonucleotides directed against UNC13A cryptic splice variant are also contemplated.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: A mechanical seal of the cartridge type. A rotary subassembly including a sleeve, the sleeve packed against and adapted to be in sealing disposition with a pump shaft of a pump; a stationary subassembly for attachment to a stuffing box of the pump, the stationary subassembly including a gland, wherein the gland has a front face and back face; and, a register defined within the gland front face, the register being an opening shaped to fit over a raised face of the stuffing box, thereby limiting side loading of the seal. In addition, a composite setting piece press-fitted into a bore between the bushing section and the drive collar, thereby allowing the seal to be preset in lieu of a screw or clip.

Abstract: A mechanical seal of the cartridge type. A rotary subassembly including a sleeve, the sleeve packed against and adapted to be in sealing disposition with a pump shaft of a pump; a stationary subassembly for attachment to a stuffing box of the pump, the stationary subassembly including a gland, wherein the gland has a front face and back face; and, a register defined within the gland front face, the register being an opening shaped to fit over a raised face of the stuffing box, thereby limiting side loading of the seal. In addition, a composite setting piece press-fitted into a bore between the bushing section and the drive collar, thereby allowing the seal to be preset in lieu of a screw or clip.

Abstract: A method includes: accessing a set of hardware parameters characterizing an embedded device; identifying a set of supported container functions based on the set of hardware parameters; accessing a selection of container functions; identifying a set of selected container functions based on the selection of container functions and the set of supported container functions; generating a hardware abstraction layer (HAL) including a set of libraries supporting the set of selected container functions; generating a container runtime environment (CRE) configured to execute, at the embedded device, a containerized application via the HAL, the containerized application including the set of selected container functions; installing the HAL and the CRE onto the embedded device; installing the containerized application onto the embedded device via the CRE; and at the embedded device, executing the containerized application via the CRE and the HAL.

Abstract: The present disclosure provides vector stuffer polynucleotides and compositions thereof, including expression constructs and vectors, such as viral vectors and methods of delivering a therapeutic agent (e.g., inhibitory nucleic acid) to a mammal or treating a disease.

Abstract: A method includes: accessing a set of hardware parameters characterizing an embedded device; identifying a set of supported container functions based on the set of hardware parameters; accessing a selection of container functions; identifying a set of selected container functions based on the selection of container functions and the set of supported container functions; generating a hardware abstraction layer (HAL) including a set of libraries supporting the set of selected container functions; generating a container runtime environment (CRE) configured to execute, at the embedded device, a containerized application via the HAL, the containerized application including the set of selected container functions; installing the HAL and the CRE onto the embedded device; installing the containerized application onto the embedded device via the CRE; and at the embedded device, executing the containerized application via the CRE and the HAL.

Abstract: The invention relates to inhibitory nucleic acids targeting the ataxin-2 gene (ATXN2), and expression cassettes and vectors comprising the same. Also provided herein are methods of treating neurodegenerative diseases, e.g., Amyotrophic Lateral Sclerosis and Spinocerebellar Ataxia-2.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: In one form, an organizing member for optical components includes an elongate body extending about a hollow interior portion and including a peripheral sidewall. The organizing member also includes an optical fiber routing surface extending from the peripheral sidewall toward the hollow interior portion, and a recessed portion is positioned between the peripheral sidewall and the hollow interior portion. The recessed portion includes a number of receptacles offset from the optical fiber routing surface and corresponding in configuration to a respective optical component positionable therein.

Abstract: A method includes: accessing a set of hardware parameters characterizing an embedded device; identifying a set of supported container functions based on the set of hardware parameters; accessing a selection of container functions; identifying a set of selected container functions based on the selection of container functions and the set of supported container functions; generating a hardware abstraction layer (HAL) including a set of libraries supporting the set of selected container functions; generating a container runtime environment (CRE) configured to execute, at the embedded device, a containerized application via the HAL, the containerized application including the set of selected container functions; installing the HAL and the CRE onto the embedded device; installing the containerized application onto the embedded device via the CRE; and at the embedded device, executing the containerized application via the CRE and the HAL.

Abstract: In one form, an organizing member for optical components includes an elongate body extending about a hollow interior portion and including a peripheral sidewall. The organizing member also includes an optical fiber routing surface extending from the peripheral sidewall toward the hollow interior portion, and a recessed portion is positioned between the peripheral sidewall and the hollow interior portion. The recessed portion includes a number of receptacles offset from the optical fiber routing surface and corresponding in configuration to a respective optical component positionable therein.

Abstract: A pluggable bidirectional optical amplifier module may include preamp and booster optical amplifiers and a housing. The preamp optical amplifier may be configured to amplify optical signals traveling in a first direction. The booster optical amplifier may be configured to amplify optical signals traveling in a second direction. The housing may at least partially enclose the preamp optical amplifier and the booster optical amplifier. The pluggable bidirectional optical amplifier module may have a mechanical form factor that is compliant with a pluggable communication module form factor MSA. A colorless mux/demux cable assembly may be operated with the pluggable bidirectional optical amplifier. The colorless mux/demux cable assembly may include a 1:N optical splitter a N:1 optical combiner coupled side-by-side to the 1:N optical splitter, a first fiber optic cable optic cable, and a second fiber optic cable.

Abstract: The present disclosure provides a helmet that includes a segmented outer shell comprising a plurality of independently movable segments. The helmet also includes internal layers that comprise flexible bearings and other optional padding to provide mobility to the segmented outer shell and to provide impact protection via force dispersion and compression of the layers of the helmet. In a first embodiment, the bearing is a substantially hemispherically-shaped node. In a second embodiment, the bearing is a substantially torus-shaped pad.

Abstract: One or more key performance indicators are necessary to properly measure the health of video surveillance applications and the supporting infrastructure. Some of the key performance indicators include: Video Path Uptime (VPU), Video Stream Delivery Index (VSDI), and, Video Retention Compliance (VRC). From these metrics, it is possible to calibrate whether a surveillance infrastructure is operating properly. These metrics can be used to properly alert video network administrators of problems that are actually affecting the video surveillance application. It is also possible to use these metrics to build better analytics to determine root cause of problems as well as build prediction models for potential problems before they occur.