Abstract: Intravascular devices, systems and methods of fabricating the same are provided. In one embodiment, an intravascular system includes an intravascular guidewire that includes a flexible elongate member having a proximal portion and a distal portion, at least one electronic component secured to the distal portion of the flexible elongate member, and a locking section integral with a metal core of the flexible elongate member at the proximal portion of the flexible elongate member. The metal core has a first diameter. The locking section includes a first subsection and a second subsection. The first subsection has a second of diameter smaller than the first diameter and the second subsection transitions between the first diameter and the second diameter.

Abstract: The present disclosure relates to a nucleic acid nanoparticle comprising a single stranded nucleic acid scaffold encoding one or more RNA molecules of interest and a plurality of single stranded nucleic acid oligomers, where each oligomer is complementary to at least a portion of the single stranded nucleic acid scaffold. Also disclosed are pharmaceutical compositions and methods of use thereof.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire that includes separate sections with engaged core components. For example, a sensing guide wire can include a proximal portion having a proximal core member and at least one proximal electrical conductor and a distal portion coupled to the proximal portion, the distal portion having a distal core member, a sensing element, and at least one distal electrical conductor coupled to the sensing element, wherein engagement structures of the proximal and distal core members are engaged and wherein the at least one distal electrical conductor is coupled to the at least one proximal electrical conductor such that the at least one proximal electrical conductor is in electrical communication with the sensing element. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire that includes separate sections with engaged core components. For example, a sensing guide wire can include a proximal portion having a proximal core member and at least one proximal electrical conductor and a distal portion coupled to the proximal portion, the distal portion having a distal core member, a sensing element, and at least one distal electrical conductor coupled to the sensing element, wherein engagement structures of the proximal and distal core members are engaged and wherein the at least one distal electrical conductor is coupled to the at least one proximal electrical conductor such that the at least one proximal electrical conductor is in electrical communication with the sensing element. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

Abstract: Intravascular devices, systems and methods of fabricating the same are provided. In one embodiment, an intravascular system includes an intravascular guidewire that includes a flexible elongate member having a proximal portion and a distal portion, at least one electronic component secured to the distal portion of the flexible elongate member, and a locking section integral with a metal core of the flexible elongate member at the proximal portion of the flexible elongate member. The metal core has a first diameter. The locking section includes a first subsection and a second subsection. The first subsection has a second of diameter smaller than the first diameter and the second subsection transitions between the first diameter and the second diameter.

Abstract: The present disclosure is directed to intravascular devices, systems, and methods having a core wire with multiple flattened sections. In one aspect, a sensing guide wire is provided. The guide wire includes a first flexible elongate member; a sensing element positioned at a distal portion of the first flexible elongate member; and a second flexible elongate member coupled to the first flexible elongate member such that the second flexible elongate member extends distally from the first flexible elongate member; and wherein a distal portion of the first flexible elongate member includes at least two flattened sections, and wherein the first and second flexible elongate members are coupled along a portion of one of the at least two flattened sections. In other aspects, methods of forming a sensing guide wire are provided.

Abstract: The present disclosure is directed to intravascular devices, systems, and methods having a core wire with multiple flattened sections. In one aspect, a sensing guide wire is provided. The guide wire includes a first flexible elongate member; a sensing element positioned at a distal portion of the first flexible elongate member; and a second flexible elongate member coupled to the first flexible elongate member such that the second flexible elongate member extends distally from the first flexible elongate member; and wherein a distal portion of the first flexible elongate member includes at least two flattened sections, and wherein the first and second flexible elongate members are coupled along a portion of one of the at least two flattened sections. In other aspects, methods of forming a sensing guide wire are provided.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire having a polymer jacket applied over communication lines and a core member, where the communication lines have been wrapped around the core member. For example, in some implementations a sensing guide wire includes a proximal portion and a distal portion, the distal portion including: a core member; a plurality of communication lines wrapped around the core member; a polymer jacket formed around the core member and the plurality of communication lines; and a sensing element positioned distal of the polymer jacket and communicatively coupled to the plurality of communication lines. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire that includes separate sections with engaged core components. For example, a sensing guide wire can include a proximal portion having a proximal core member and at least one proximal electrical conductor and a distal portion coupled to the proximal portion, the distal portion having a distal core member, a sensing element, and at least one distal electrical conductor coupled to the sensing element, wherein engagement structures of the proximal and distal core members are engaged and wherein the at least one distal electrical conductor is coupled to the at least one proximal electrical conductor such that the at least one proximal electrical conductor is in electrical communication with the sensing element. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire that includes separate sections with engaged core components. For example, a sensing guide wire can include a proximal portion having a proximal core member and at least one proximal electrical conductor and a distal portion coupled to the proximal portion, the distal portion having a distal core member, a sensing element, and at least one distal electrical conductor coupled to the sensing element, wherein engagement structures of the proximal and distal core members are engaged and wherein the at least one distal electrical conductor is coupled to the at least one proximal electrical conductor such that the at least one proximal electrical conductor is in electrical communication with the sensing element. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

Abstract: Intravascular devices are disclosed, comprising a core member and a radiopaque marker element formed of a single length of material wound in a coil, wherein a first pitch of a first portion of the coil differs from a second pitch of a second portion of the coil.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire with an adhesive filled flexible element. For example, in some implementations a sensing guide wire includes a flexible elongate member; a flexible element extending distally from the flexible elongate member; a core member extending within a lumen of the flexible element; at least one flexible adhesive filling at least a portion of the lumen between the core member and the flexible element along a length of the flexible element; and a sensing element positioned distal of the flexible element. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, side-loading electrical connectors for use with intravascular devices are provided. The side-loading electrical connector has at least one electrical contact configured to interface with an electrical connector of the intravascular device. A first connection piece of the side-loading electrical connector is movable relative to a second connection piece such that in an open position an elongated opening is formed between the first and second connection pieces to facilitate side-loading of the intravascular device into the connector and in the closed position the at least one electrical contact is electrically coupled to the at least one electrical connector of the intravascular device received between the first and second connection pieces and a communication cable extends from the connector in a direction coaxial with or parallel to the longitudinal axis of the intravascular device.

Abstract: Intravascular devices, systems and methods of fabricating the same are provided. In one embodiment, an intravascular system includes an intravascular guidewire that includes a flexible elongate member having a proximal portion and a distal portion, at least one electronic component secured to the distal portion of the flexible elongate member, and a locking section integral with a metal core of the flexible elongate member at the proximal portion of the flexible elongate member. The metal core has a first diameter. The locking section includes a first subsection and a second subsection. The first subsection has a second of diameter smaller than the first diameter and the second subsection transitions between the first diameter and the second diameter.

Abstract: Drug delivery balloons have densely packed crystals of small particle size of the drug thereon. An amorphous drug coating is applied to a balloon surface and annealed to provide the crystals. The balloon surface is nucleated to induce formation of drug crystals in the annealing step to provide the crystals in high density with small size.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, side-loading electrical connectors for use with intravascular devices are provided. The side-loading electrical connector has at least one electrical contact configured to interface with an electrical connector of the intravascular device. A first connection piece of the side-loading electrical connector is movable relative to a second connection piece such that in an open position an elongated opening is formed between the first and second connection pieces to facilitate side-loading of the intravascular device into the connector and in the closed position the at least one electrical contact is electrically coupled to the at least one electrical connector of the intravascular device received between the first and second connection pieces and a communication cable extends from the connector in a direction coaxial with or parallel to the longitudinal axis of the intravascular device.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire having a polymer jacket applied over communication lines and a core member, where the communication lines have been wrapped around the core member. For example, in some implementations a sensing guide wire includes a proximal portion and a distal portion, the distal portion including: a core member; a plurality of communication lines wrapped around the core member; a polymer jacket formed around the core member and the plurality of communication lines; and a sensing element positioned distal of the polymer jacket and communicatively coupled to the plurality of communication lines. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire with an adhesive filled flexible element. For example, in some implementations a sensing guide wire includes a flexible elongate member; a flexible element extending distally from the flexible elongate member; a core member extending within a lumen of the flexible element; at least one flexible adhesive filling at least a portion of the lumen between the core member and the flexible element along a length of the flexible element; and a sensing element positioned distal of the flexible element. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided.

Abstract: The present disclosure is directed to intravascular devices, systems, and methods having a core wire with multiple flattened sections. In one aspect, a sensing guide wire is provided. The guide wire includes a first flexible elongate member; a sensing element positioned at a distal portion of the first flexible elongate member; and a second flexible elongate member coupled to the first flexible elongate member such that the second flexible elongate member extends distally from the first flexible elongate member; and wherein a distal portion of the first flexible elongate member includes at least two flattened sections, and wherein the first and second flexible elongate members are coupled along a portion of one of the at least two flattened sections. In other aspects, methods of forming a sensing guide wire are provided.