Abstract: Disclosed are devices and methods for facilitating directed delivery of a medicament into a human organ of a patient. An apparatus to facilitate directed delivery of a medicament into a human organ of a patient may include a container configured to enclose the medicament, a needle having a passage therethrough and a sharp distalmost tip, and a needle guard at least partially surrounding a shaft of the needle. The needle guard may include a distal surface, wherein the sharp distalmost tip of the needle may be configured to extend through an opening in the distal surface. The needle guard may be moveable relative to the needle along an axis of the needle to control a distance from the distal surface to the distalmost tip of the needle.

Abstract: Needle spacers for use in administering subcutaneous injections, as well as subcutaneous injection systems including such needle spacers, are disclosed. In certain embodiments, the needle spacer comprises a first portion configured to engage a hub of a needle that comprises such a hub; and a second portion coupled to the first portion and extending distally therefrom, the second portion including a skin-contacting surface disposed on a distal end thereof, wherein the skin-contacting surface is configured to engage a surface of skin of a subject. The second portion is configured to maintain a predetermined distance between the hub of the needle and the surface of the skin, and to permit insertion of the needle to a depth of about 4 mm to about 8 mm below the surface of the skin during administration of a subcutaneous injection via the needle.