Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting PMP22 expression and for treating, preventing, or ameliorating a disease associated with PMP22.

Abstract: A method of patterning a substrate includes forming a first line, a second line, and a third line over the substrate, the first line, the second line, and the third line being parallel in a plan view, and forming a fourth line and a fifth line over the first line, the second line, and the third line, the fourth line and the fifth line being orthogonal to the first line in the plan view. The method further includes etching a hole through the second line using the first line, the third line, the fourth line, and the fifth line as an etching mask, and filling the hole with a dielectric material to form a block.

Abstract: Methods, systems, and techniques for facilitating proactive recruitment are disclosed, comprising: receiving a user annotation of a candidate profile stored in a database, the user annotation provided by a user; based on at least the received user annotation, determining a sentiment of the user with respect to a candidate associated with the candidate profile; and when the sentiment of the user is determined to be positive, scheduling a notification to be sent to the user in response to a trigger event.

Abstract: An apparatus and methods are provided for a gas regulator valve for adjusting cycle speeds of direct gas impingement operated firearms. The gas regulator valve comprises a gas inlet for receiving expanding gases from a fired cartridge and a gas tube for directing the expanding gases to a bolt carrier comprising a firearm. The gas inlet is disposed at the front of an upper receiver comprising the firearm. The gas tube directs the expanding gases into a carrier key of the bolt carrier. The gas regulator valve includes a plug for controlling gas flow through the gas tube. An actuator disposed on a side of the upper receiver enables operating the plug. The actuator enables a practitioner to adjust the flow of expanding gases without moving the firearm out of a shooting position. The actuator includes a key that may be turned by a rim of an ammunition cartridge.

Abstract: An apparatus and methods are provided for a front plate having a diverging central bore for firearm sound suppressors that improves noise and flash characteristics during firing a weapon. The central bore is disposed between a back surface and a front surface of the front plate. An untapered portion of the central bore extends from the back surface to a diverging portion that opens toward the front surface. The diverging portion includes a curvature profile configured to allow for more controlled expansion of high-pressure propellant gases exiting of the suppressor through the central bore. The curvature profile provides an included angle of the central bore that decreases secondary flash events accompanying the expulsion of propellant gases accompanying a fired bullet exiting the suppressor through the central bore. The curvature profile exhibits a cross-sectional area of the central bore that is proportional to a distance along the diverging portion.

Abstract: An apparatus and methods are provided for a front plate having a diverging central bore for firearm sound suppressors that improves noise and flash characteristics during firing a weapon. The central bore is disposed between a back surface and a front surface of the front plate. An untapered portion of the central bore extends from the back surface to a diverging portion that opens toward the front surface. The diverging portion includes a curvature profile configured to allow for more controlled expansion of high-pressure propellant gases exiting of the suppressor through the central bore. The curvature profile provides an included angle of the central bore that decreases secondary flash events accompanying the expulsion of propellant gases accompanying a fired bullet exiting the suppressor through the central bore. The curvature profile exhibits a cross-sectional area of the central bore that is proportional to a distance along the diverging portion.

Abstract: An apparatus and methods are provided for a suppressor to be coupled with a muzzle end of a barrel of a firearm to reduce muzzle blast and muzzle flash. The suppressor comprises a housing having a proximal end and a distal end. A front portion within the housing comprises a series of cylindrical gas expansion chambers for attenuating the temperature and energy of propellant gases accompanying a projectile fired from the firearm. An annular gas expansion chamber surrounds the cylindrical gas expansion chambers and directs a portion of the propellant gases from a rear portion of the suppressor to peripheral vents disposed at the distal end. Lateral chambers within the rear portion deflect and rebound a portion of the propellant gases before passing them into the annular gas expansion chamber. Ledges within the annular gas expansion chamber direct the propellant gases distally through suppressor toward the peripheral vents.

Abstract: An apparatus and methods are provided for a suppressor to be coupled with a muzzle end of a barrel of a firearm to reduce muzzle blast and muzzle flash. The suppressor comprises a housing having a proximal end and a distal end. A front portion within the housing comprises a series of cylindrical gas expansion chambers for attenuating the temperature and energy of propellant gases accompanying a projectile fired from the firearm. An annular gas expansion chamber surrounds the cylindrical gas expansion chambers and directs a portion of the propellant gases from a rear portion of the suppressor to peripheral vents disposed at the distal end. Lateral chambers within the rear portion deflect and rebound a portion of the propellant gases before passing them into the annular gas expansion chamber. Ledges within the annular gas expansion chamber direct the propellant gases distally through suppressor toward the peripheral vents.

Abstract: A laser leveling tool comprises at least one laser diode for emitting a laser beam; a micro controller unit for controlling the operation of the laser diode; and a thermal sensor for sensing the internal temperature of the laser leveling tool; wherein the micro controller unit is configured to reduce the operation power of the laser diode when the sensed internal temperature reaches a temperature threshold.

Abstract: A laser leveling tool comprises at least one laser diode for emitting a laser beam; a micro controller unit for controlling the operation of the laser diode; and a thermal sensor for sensing the internal temperature of the laser leveling tool; wherein the micro controller unit is configured to reduce the operation power of the laser diode when the sensed internal temperature reaches a temperature threshold.

Abstract: A multifunction laser leveling tool (1) is provided. The multifunction laser leveling tool (1) comprises: a housing (2); a pendulum (28) supported by the housing (2) via a universal joint so that the pendulum (28) is pivotable with respect to the housing (2) around a first axis (24) and a second axis (26) perpendicular to the first axis (24); a locking means (4) which is able to fixedly lock the pendulum (28) to the housing (2) and to release the pendulum (28) therefrom, wherein when the pendulum (28) is released, the pendulum (28) is in a plumb orientation and the first and second axes (24,26) lie in a horizontal plane; a first laser beam emitter (36) attached to the pendulum (28) for emitting a first laser plane; an angle sensing means (44) attached to the pendulum (28) for measuring the orientation of the pendulum (28); a display module having two sections (6,8) attached to the housing (2) for displaying the measured orientation of the pendulum (28).

Abstract: A multifunction laser leveling tool (1) is provided. The multifunction laser leveling tool (1) comprises: a housing (2); a pendulum (28) supported by the housing (2) via a universal joint so that the pendulum (28) is pivotable with respect to the housing (2) around a first axis (24) and a second axis (26) perpendicular to the first axis (24); a locking means (4) which is able to fixedly lock the pendulum (28) to the housing (2) and to release the pendulum (28) therefrom, wherein when the pendulum (28) is released, the pendulum (28) is in a plumb orientation and the first and second axes (24,26) lie in a horizontal plane; a first laser beam emitter (36) attached to the pendulum (28) for emitting a first laser plane; an angle sensing means (44) attached to the pendulum (28) for measuring the orientation of the pendulum (28); a display module having two sections (6,8) attached to the housing (2) for displaying the measured orientation of the pendulum (28).

Abstract: A first device comprising a transceiver module configured to begin transmission of a first signal to a second device. A control module is configured to, in response to the transceiver module receiving a second signal during the transmission of the first signal to the second device, determine whether the second signal corresponds to crosstalk by having the transceiver module suspend the transmission of the first signal. In response to the transceiver module continuing to receive the second signal subsequent to the transceiver module having suspended the transmission of the first signal to the second device, the control module determines that the second signal does not correspond to crosstalk. In response to the transceiver module not continuing to receive the second signal subsequent to the transceiver module having suspended the transmission of the first signal to the second device, the control module determines that the second signal does correspond to crosstalk.

Abstract: An integrated circuit is provided that includes an execution engine and a memory controller. The execution engine is clocked at a first rate and the memory controller is clocked at a second rate that is less than the first rate. Pins on the integrated circuit can transfer data to and from the integrated circuit on both the rising and falling edges of a second clock transitioning at the second clock rate. The integrated circuit is preferably packaged using a lead frame and wire bonds extending from pads on the integrated circuit to corresponding leads. The leads are secured to trace conductors on a surface of a printed circuit board. The board contains no more than two conductive layers separated by a dielectric layer.

Abstract: An integrated circuit is provided that includes an execution engine and a memory controller. The execution engine is clocked at a first rate and the memory controller is clocked at a second rate that is less than the first rate. Pins on the integrated circuit can transfer data to and from the integrated circuit on both the rising and falling edges of a second clock transitioning at the second clock rate. The integrated circuit is preferably packaged using a lead frame and wire bonds extending from pads on the integrated circuit to corresponding leads. The leads are secured to trace conductors on a surface of a printed circuit board. The board contains no more than two conductive layers separated by a dielectric layer.

Abstract: An apparatus comprising a first portion, a second portion and a processor. The first portion is configured to generate a count signal in response to a number of oscillations of a clock signal. The first portion is powered by an unswitched power source. The second portion is configured to generate an interrupt signal in response to the count signal and a predetermined stored value. The second portion is powered by a switched power source. The processor is configured to (i) receive the interrupt signal and (ii) generate the switched power.

Abstract: An apparatus comprising a phase lock loop circuit and a control circuit. The phase lock loop circuit configured to generate an output signal having a first frequency in response to (i) an input signal having a second frequency, (ii) a first divider value and (iii) a second divider value. The second divider value may control spread spectrum modulation of the phase lock loop circuit. The control circuit configured to generate the second divider value in response to (i) the output signal and (ii) a programmable control signal.

Abstract: A self contained micro controller based personal barcode shopping aid system that includes a barcode reader, a manual input device, a display device, a printing device, and build-in database to input, display, store and output personal shopping list using barcodes. This system also stores and organizes coupons barcodes. The system will remind user when there is a possible match between items in the shopping list and cost saving coupons.

Abstract: A memory controller is provided and a method for transferring data between the memory controller and a memory device. The memory controller can be implemented on an integrated circuit that also contains an execution unit. The execution unit can be clocked at a first clock rate, whereas the memory controller can be selectively clocked at either the first clock rate or a second clock rate that is approximately one-half frequency of the first clock rate. By clocking the memory controller at either the first clock rate or the second clock rate, the memory controller can accommodate different types of semiconductor memory. For example, the memory controller can control single data rate (SDR) DRAM memory if it is clocked at a first clock rate. Conversely, the memory controller can control double data rate (DDR) DRAM memory if it is clocked at approximately one-half the first clock rate.

Abstract: An apparatus comprising a phase lock loop circuit and a control circuit. The phase lock loop circuit may be configured to generate an output signal having a first frequency in response to (i) an input signal having a second frequency, (ii) a first divider value and (iii) a second divider value. The second divider value may control spread spectrum modulation of the phase lock loop circuit. The control circuit may be configured to generate the second divider value in response to (i) the output signal and (ii) a programmable control signal.