Abstract: A method of synthesizing rubidium uranium fluoride crystals. The method includes combining uranium-based feedstock with a mineralizer solution that includes a rubidium fluoride. The feedstock and mineralizer solution are pressurized and a thermal gradient applied thereto such that a first portion of the feedstock and the mineralizer solution is heated to a temperature that is greater than a temperature of a second portion of the feedstock and the mineralizer solution. Uranium nutrient enters the mineralizer solution from the feedstock in the first portion and uranium nutrient precipitates to spontaneously form crystals in the second portion.

Abstract: A method of synthesizing uranium dioxide crystals. The method of synthesizing includes combining a uranium-based feedstock with a mineralizer solution. The uranium-based feedstock is selected from uranium dioxide, uranium tetrafluoride, uranium tetrachloride, triuranium octoxide, and uranium trioxide. The feedstock and mineralizer solution are pressurized, and then a thermal gradient is applied thereto such that a first portion of the feedstock and the mineralizer solution is heated to a temperature that is greater than a temperature of a second portion of the feedstock and the mineralizer solution. The uranium nutrient enters the mineralizer solution from the feedstock in the first portion and uranium nutrient precipitates to spontaneously form crystals in the second portion.

Abstract: A method of synthesizing alkali uranium fluorophosphate crystals. The method includes combining a uranium-based feedstock with a mineralizer solution. The mineralizer solution includes an alkali nutrient, a phosphate, and a fluoride. The feedstock and mineralizer solution are pressurized and a thermal gradient applied thereto such that a first portion of the feedstock and the mineralizer solution is heated to a temperature that is greater than a temperature of a second portion of the feedstock and the mineralizer solution. Uranium nutrient enters the mineralizer solution from the feedstock in the first portion and uranium nutrient precipitates to spontaneously form crystals in the second portion.

Abstract: A method of synthesizing rubidium uranium fluoride crystals. The method includes combining uranium-based feedstock with a mineralizer solution that includes a rubidium fluoride. The feedstock and mineralizer solution are pressurized and a thermal gradient applied thereto such that a first portion of the feedstock and the mineralizer solution is heated to a temperature that is greater than a temperature of a second portion of the feedstock and the mineralizer solution. Uranium nutrient enters the mineralizer solution from the feedstock in the first portion and uranium nutrient precipitates to spontaneously form crystals in the second portion.

Abstract: A method of synthesizing uranium dioxide crystals. The method of synthesizing includes combining a uranium-based feedstock with a mineralizer solution. The uranium-based feedstock is selected from uranium dioxide, uranium tetrafluoride, uranium tetrachloride, triuranium octoxide, and uranium trioxide. The feedstock and mineralizer solution are pressurized, and then a thermal gradient is applied thereto such that a first portion of the feedstock and the mineralizer solution is heated to a temperature that is greater than a temperature of a second portion of the feedstock and the mineralizer solution. The uranium nutrient enters the mineralizer solution from the feedstock in the first portion and uranium nutrient precipitates to spontaneously form crystals in the second portion.

Abstract: A method of synthesizing alkali uranium fluorophosphate crystals. The method includes combining a uranium-based feedstock with a mineralizer solution. The mineralizer solution includes an alkali nutrient, a phosphate, and a fluoride. The feedstock and mineralizer solution are pressurized and a thermal gradient applied thereto such that a first portion of the feedstock and the mineralizer solution is heated to a temperature that is greater than a temperature of a second portion of the feedstock and the mineralizer solution. Uranium nutrient enters the mineralizer solution from the feedstock in the first portion and uranium nutrient precipitates to spontaneously form crystals in the second portion.

Abstract: A goniometer base for X-ray crystallography comprises a magnetic steel part with a cylindrical hole, a compliant cylindrical part that is inserted into this hole, and a cylindrical tube that is press-fit into the hole and holds the compliant part in place, such that when a crystal mounting tool is inserted through the concentric holes in each part, it is positively gripped and held in place at both T=300 K and T=100 K.

Abstract: A goniometer base for X-ray crystallography comprises a magnetic steel part with a cylindrical hole, a compliant cylindrical part that is inserted into this hole, and a cylindrical tube that is press-fit into the hole and holds the compliant part in place, such that when a crystal mounting tool is inserted through the concentric holes in each part, it is positively gripped and held in place at both T=300 K and T=100 K.

Abstract: The present invention relates to a novel polymorph, to processes for the preparation of the polymorph and to the use of the polymorph in medicine, particularly antibacterial therapy.

Abstract: The present invention relates to 14- or 15-membered macrolides substituted at the 4? position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

Abstract: A compound of formula (I) and/or pharmaceutically acceptable derivatives thereof, having antimicrobial activity, processes for their preparation, compositions containing them and to their use in medicine.

Abstract: Pleuromutilin compounds of the formula: are of use in antibacterial therapy.

Abstract: The present invention relates to 14- or 15-membered macrolides substituted at the 4? position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

Abstract: A compound of formula (I): wherein R? is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; R? is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; or R? and R? together form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms; R1 is (C1-6)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a removable hydroxy protecting group, or by an amino group which is optionally protected by a removable amino protecting group; R2 is hydrogen or methyl; and —CO2R3 is carboxy or a carboxylate anion or the group R3 is a removable carboxy protecting group. This invention also relates to processes for its preparation, intermediates and pharmaceutical compositions comprising compounds of formula (I).

Abstract: 2-(S)-hydroxymutilin carbamate derivatives of formula (I), in which R1 is a 5- or 6-membered optionally substituted heteroaryl group; and R2 is vinyl or ethyl, are useful in the treatment of bacterial infections

Abstract: Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy.

Abstract: Pleuromutilin compounds of the formula: 1

Abstract: A compound of formula (I): 1

Abstract: The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.

Abstract: The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.