Patents by Inventor Eric J. Herbig

Eric J. Herbig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • B CELLS FOR IN VIVO DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20230081163
    Abstract: The present disclosure relates to genetically modified B cells, including memory cells, differentiated to plasmablasts or plasma cells useful for long term in vivo expression of a transgene, such as a specific antibody or other protein therapeutic. Also disclosed are methods of producing the cells and methods of treatment.
    Type: Application
    Filed: August 11, 2022
    Publication date: March 16, 2023
    Inventors: Matthew Rein SCHOLZ, Eric J. HERBIG, Mei XU, Rian DE LAAT
  • METHODS FOR IN VITRO MEMORY B CELL DIFFERENTIATION AND TRANSDUCTION WITH VSV-G PSEUDOTYPED VIRAL VECTORS
    Publication number: 20230013198
    Abstract: The present disclosure relates to the in vitro differentiation of memory B cells to plasmablasts or plasma cells and genetic modification of these cells to express a protein of interest, such as a specific antibody or other protein therapeutic.
    Type: Application
    Filed: May 3, 2022
    Publication date: January 19, 2023
    Inventors: Mei XU, Matthew Rein SCHOLZ, Eric J. HERBIG
  • B CELLS FOR IN VIVO DELIVERY OF THERAPEUTIC AGENTS AND DOSAGES THEREOF
    Publication number: 20220193129
    Abstract: The present invention relates to methods for administering autologous and/or allogeneic B cells genetically modified to produce a therapeutic agent, such as a therapeutic protein. Specifically disclosed are methods for administering a single, maximally effective dose of genetically modified B cells and for administering multiple doses of genetically modified B cells. The compositions and methods disclosed herein are useful for the long-term, in vivo delivery of a therapeutic agent.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 23, 2022
    Inventors: Matthew Rein Scholz, Eric J. HERBIG, R. Scott MCIVOR, Rian DE LAAT, Erik Olson
  • Methods for in vitro memory B cell differentiation and transduction with VSV-G pseudotyped viral vectors
    Patent number: 11352603
    Abstract: The present disclosure relates to the in vitro differentiation of memory B cells to plasmablasts or plasma cells and genetic modification of these cells to express a protein of interest, such as a specific antibody or other protein therapeutic.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: June 7, 2022
    Assignee: Immusoft Corporation
    Inventors: Mei Xu, Matthew Rein Scholz, Eric J. Herbig
  • B CELLS GENETICALLY ENGINEERED TO SECRETE FOLLISTATIN AND METHODS OF USING THE SAME TO TREAT FOLLISTATIN-RELATED DISEASES, CONDITIONS, DISORDERS AND TO ENHANCE MUSCLE GROWTH AND STRENGTH
    Publication number: 20210047619
    Abstract: The present invention relates to methods for administering autologous and/or allogeneic B cells genetically modified to produce a therapeutic agent, such as follistatin. Specifically disclosed are methods for administering a single, maximally effective dose of genetically modified B cells and for administering multiple doses of genetically modified B cells that express follistatin. The compositions and methods disclosed herein are useful for the long-term, in vivo delivery of follistatin.
    Type: Application
    Filed: March 18, 2019
    Publication date: February 18, 2021
    Inventors: Matthew Rein SCHOLZ, Eric J. HERBIG, R. Scott MCIVOR
  • METHODS FOR IN VITRO MEMORY B CELL DIFFERENTIATION AND TRANSDUCTION WITH VSV-G PSEUDOTYPED VIRAL VECTORS
    Publication number: 20190241870
    Abstract: The present disclosure relates to the in vitro differentiation of memory B cells to plasmablasts or plasma cells and genetic modification of these cells to express a protein of interest, such as a specific antibody or other protein therapeutic.
    Type: Application
    Filed: February 4, 2019
    Publication date: August 8, 2019
    Inventors: Mei XU, Matthew Rein SCHOLZ, Eric J. HERBIG
  • Methods for in vitro memory B cell differentiation and transduction with VSV-G pseudotyped viral vectors
    Patent number: 10240125
    Abstract: The present disclosure relates to the in vitro differentiation of memory B cells to plasmablasts or plasma cells and genetic modification of these cells to express a protein of interest, such as a specific antibody or other protein therapeutic.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 26, 2019
    Assignee: Immusoft Corporation
    Inventors: Mei Xu, Matthew Rein Scholz, Eric J. Herbig
  • B CELLS FOR IN VIVO DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20180002664
    Abstract: The present disclosure relates to genetically modified B cells, including memory cells, differentiated to plasmablasts or plasma cells useful for long tem in vivo expression of a transgene, such as a specific antibody or other protein therapeutic. Also disclosed are methods of producing the cells and methods of treatment.
    Type: Application
    Filed: December 18, 2015
    Publication date: January 4, 2018
    Inventors: Matthew Rein SCHOLZ, Eric J. HERBIG, Mei XU, Rian DE LAAT
  • METHODS FOR IN VITRO MEMORY B CELL DIFFERENTIATION AND TRANSDUCTION WITH VSV-G PSEUDOTYPED VIRAL VECTORS
    Publication number: 20160046908
    Abstract: The present disclosure relates to the in vitro differentiation of memory B cells to plasmablasts or plasma cells and genetic modification of these cells to express a protein of interest, such as a specific antibody or other protein therapeutic.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 18, 2016
    Inventors: Mei Xu, Matthew Rein Scholz, Eric J. Herbig
  • Vectors and methods for transducing B cells
    Patent number: 9074223
    Abstract: The present disclosure provides compositions and methods for transducing B cells. In particular, the present disclosure provides for vectors and methods for transducing resting B cells and methods for differentiating same to express a transgene of interest.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: July 7, 2015
    Assignee: Immusoft Corporation
    Inventors: Matthew Rein Scholz, Eric J. Herbig
  • VECTORS AND METHODS FOR TRANSDUCING B CELLS
    Publication number: 20130143267
    Abstract: The present disclosure provides compositions and methods for transducing B cells. In particular, the present disclosure provides for vectors and methods for transducing resting B cells and methods for differentiating same to express a transgene of interest.
    Type: Application
    Filed: January 7, 2011
    Publication date: June 6, 2013
    Applicant: IMMUSOFT CORPORATION
    Inventors: Matthew Rein Scholz, Eric J. Herbig