Patents by Inventor Eric J. Kunkel

Eric J. Kunkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biological dataset profiling of cardiovascular disease and cardiovascular inflammation
    Patent number: 9734282
    Abstract: Methods and systems for evaluating biological dataset profiles relating to inflammatory cardiovascular conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: August 15, 2017
    Assignee: DISCOVERX CORPORATION
    Inventors: Jennifer Melrose, Elen Rosler, Melissa Fischer, Sylvie Privat, Eric J. Kunkel, Ellen Berg
  • Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
    Patent number: 9512125
    Abstract: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: December 6, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kevan M. Shokat, Nikolai Sepetov, Chao Zhang, Heinz W. Gschwend, Eric J. Kunkel
  • AGENTS AND DEVICES FOR USE IN PREVENTION OF RESTENOSIS
    Publication number: 20140288032
    Abstract: Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 25, 2014
    Applicant: DiscoveRx Corporation
    Inventors: Eric J. Kunkel, Evangelos Hytopoulos, Ivan Plavec
  • Methods for identifying agents and their use for the prevention of restenosis
    Patent number: 8697387
    Abstract: Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: April 15, 2014
    Assignee: DiscoverRx Corporation
    Inventors: Eric J. Kunkel, Evangelos Hytopoulos, Ivan Plavec
  • Biological dataset profiling of asthma and atopy
    Patent number: 8019551
    Abstract: Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: September 13, 2011
    Assignee: Bioseek LLC
    Inventors: Elen S. Rosler, Eric J. Kunkel, Sylvie Privat, Jennifer Melrose, Melissa Fischer, Ellen L. Berg
  • Anti-Inflammatory Pyrazolopyrimndines
    Publication number: 20110144134
    Abstract: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
    Type: Application
    Filed: January 31, 2011
    Publication date: June 16, 2011
    Applicant: The Regents of the University of California
    Inventors: Kevan M. Shokat, Nikolai Sepetov, Chao Zhang, Heinz W. Gschwend, Eric J. Kunkel
  • METHODS FOR IDENTIFYING AGENTS AND THEIR USE FOR THE PREVENTION OR STABILIZATION OF FIBROSIS
    Publication number: 20100093613
    Abstract: Agents that stabilize and/or prevent fibrosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on matrix deposition and remodeling, epithelial health, and inflammation. Treatment for fibrosis is provided using compositions of the invention.
    Type: Application
    Filed: March 10, 2008
    Publication date: April 15, 2010
    Inventors: Eric J. Kunkel, Elen S. Rosler, Sylvie Private, Jennifer E. Melrose
  • METHODS FOR IDENTIFYING AGENTS AND THEIR USE FOR THE PREVENTION OF RESTENOSIS
    Publication number: 20090304769
    Abstract: Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.
    Type: Application
    Filed: June 4, 2007
    Publication date: December 10, 2009
    Inventors: Eric J. Kunkel, Evangelos Hytopoulos, Ivan Plavec
  • ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES
    Publication number: 20090124638
    Abstract: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
    Type: Application
    Filed: November 21, 2005
    Publication date: May 14, 2009
    Applicants: Regents of the University of California, BIOSEEK, INC.
    Inventors: Kevan M. Shokat, Nikolai Sepetov, Chao Zhang, Heinz W. Gschwend, Eric J. Kunkel
  • BIOLOGICAL DATASET PROFILING OF CARDIOVASCULAR DISEASE AND CARDIOVASCULAR INFLAMMATION
    Publication number: 20090118133
    Abstract: Methods and systems for evaluating biological dataset profiles relating to inflammatory cardiovascular conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.
    Type: Application
    Filed: March 28, 2006
    Publication date: May 7, 2009
    Inventors: Jennifer Melrose, Elen Rosler, Melissa Fischer, Sylvie Privat, Eric J. Kunkel, Ellen Berg
  • Method for identifying agents which modulate chemokine “MEC”-induced functions of CCR3
    Patent number: 6692922
    Abstract: The invention relates to the interaction of MEC with CCR3 and/or CCR10 and to agents (e.g., ligands, antibodies, antagonists, agonists, inhibitors, promoters) which alter said interaction. In one aspect, the invention relates to methods for detecting or identifying an agent (i.e., molecule or compound) which can modulate (inhibit, promote) the binding of MEC to CCR3 and/or CCR10. In another aspect, the invention relates to a method of treating a subject having an inflammatory condition, comprising administering to the subject an effective amount of an agent which modulates the binding of MEC to CCR3 and/or CCR10.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: February 17, 2004
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Millennium Pharmaceuticals, Inc.
    Inventors: Eugene C. Butcher, Eric J. Kunkel, Junliang Pan, Dulce Soler-Ferrán
  • Method for identifying agents which modulate chemokine "MEC"-induced functions of CCR3 and/or CCR10
    Publication number: 20020137107
    Abstract: The invention relates to the interaction of MEC with CCR3 and/or CCR10 and to agents (e.g., ligands, antibodies, antagonists, agonists, inhibitors, promoters) which alter said interaction. In one aspect, the invention relates to methods for detecting or identifying an agent (i.e., molecule or compound) which can modulate (inhibit, promote) the binding of MEC to CCR3 and/or CCR10. In another aspect, the invention relates to a method of treating a subject having an inflammatory condition, comprising administering to the subject an effective amount of an agent which modulates the binding of MEC to CCR3 and/or CCR10.
    Type: Application
    Filed: August 15, 2001
    Publication date: September 26, 2002
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Eugene C. Butcher, Eric J. Kunkel, Junliang Pan, Dulce Soler-Ferran