Patents by Inventor Eric J. Sorscher

Eric J. Sorscher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant bacterial cells for delivery of PNP to tumor cells
    Publication number: 20030134819
    Abstract: The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells.
    Type: Application
    Filed: July 18, 2002
    Publication date: July 17, 2003
    Inventors: Eric J. Sorscher, William B. Parker, William Waud, Vijayakrishna K. Gadi, Leonard L. Bennett
  • Recombinant bacterial cells for delivery of PNP to tumor cells
    Publication number: 20030077268
    Abstract: The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells.
    Type: Application
    Filed: July 18, 2002
    Publication date: April 24, 2003
    Inventors: Eric J. Sorscher, William B. Parker, William Waud, Vijayakrishna K. Gadi, Leonard L. Bennett
  • Recombinant bacterial cells for delivery of PNP to tumor cells
    Patent number: 6491905
    Abstract: The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: December 10, 2002
    Assignees: The UAB Research Foundation, Southern Research Institute
    Inventors: Eric J. Sorscher, William B. Parker, William Waud, Vijayakrishna K. Gadi, Leonard L. Bennett, Jr.
  • Activating Cl- secretion
    Publication number: 20020035138
    Abstract: Compounds represented by formula (I), 1
    Type: Application
    Filed: April 30, 2001
    Publication date: March 21, 2002
    Applicant: Southern Research Institute
    Inventors: Joseph A. Maddry, Eric J. Sorscher
  • Activating C1- secretion
    Patent number: 6251930
    Abstract: Diazoimidazole compounds for activating Cl-secretion are disclosed that can be used for treating cystic fibrosis.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: June 26, 2001
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Joseph A. Maddry, Eric J. Sorscher
  • Purine nucleoside phosphorylase gene therapy for human malignancy
    Patent number: 6017896
    Abstract: The present invention provides a method of killing replicating or non-replicating, transfected or transduced mammalian cells and bystander cells, comprising: (a) transfecting or transducing mammalian cells with a nucleic acid encoding a non-human purine cleavage enzyme; and (b) contacting the transfected or transduced cells with an effective amount of a substrate for the purine cleavage enzyme, wherein the substrate is non-toxic to mammalian cells and is cleaved by the enzyme to yield a purine toxic to the targeted mammalian cells and bystander cells, to kill the mammalian cells expressing the enzyme and the bystander cells. Further provided is a vector comprising a DNA sequence coding for a non-human purine nucleoside phosphorylase protein and the vector is capable of replication and/or expression in a host which comprises, in operable linkage: a) optionally, an origin of replication; b) a promoter; and c) a DNA sequence coding for said protein.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: January 25, 2000
    Assignee: University of Alabama Research Foundation and Southern Research Institute
    Inventors: Eric J. Sorscher, Leonard L. Bennett, Jr., William B. Parker
  • Purine nucleoside phosphorylase gene therapy for human malignancy
    Patent number: 5552311
    Abstract: The invention provides a method of killing replicating or non-replicating, transfected or transduced mammalian cells and bystander cells, comprising the following steps: (a) transfecting or transducing mammalian cells with a nucleic acid encoding a non-human purine nucleoside phosphorylase (PNP); and (b) contacting the transfected or transduced cells with an amount of a substrate for the purine nucleoside phosphorylase sufficient to produce a toxic purine base-analog thereby killing the transfected or transduced cells and bystander cells. In the present method of killing cells, the non-human purine nucleoside phosphorylase can be an E. coli purine nucleoside phosphorylase. The method of the invention described above can utilize a substrate that is a purine nucleoside analog. For instance, in the method provided in the Examples, the substrate is 9-(.beta.-D-2-deoxyerythropentofuranosyl)-6-methylpurine (MeP-dR).
    Type: Grant
    Filed: September 14, 1993
    Date of Patent: September 3, 1996
    Assignees: University of Alabama at Birmingham Research Foundation, Southern Research Inst.
    Inventors: Eric J. Sorscher, William B. Parker, Leonard L. Bennett, Jr.