Patents by Inventor Eric Johansen
Eric Johansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240076378Abstract: Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.Type: ApplicationFiled: October 25, 2023Publication date: March 7, 2024Inventors: Volker SCHELLENBERGER, Eric JOHANSEN, Angela HENKENSIEFKEN, Darragh MACCANN, James MCCLORY, Philipp KUHN, Andre FRENZEL, Bryan IRVING, Mika DERYNCK
-
Publication number: 20230322922Abstract: Disclosed herein are polypeptides, and methods of making and using such polypeptides, that comprise a bispecific antibody construct covalently linked to an extended recombinant polypeptide comprising a barcode fragment releasable from said polypeptide upon digestion by a protease, and a Release Segment that can be proteolytically cleaved wherein said cleavage releases the bispecific antibody construct from the extended recombinant polypeptide.Type: ApplicationFiled: December 10, 2022Publication date: October 12, 2023Inventors: Volker SCHELLENBERGER, Eric JOHANSEN, Angela HENKENSIEFKEN, Darragh MACCANN, James MCCLORY, Philipp KUHN, Andre FRENZEL, Milton TO, Michael FOX, Bryan IRVING, Mika DERYNCK
-
Publication number: 20230287040Abstract: Disclosed herein are polypeptides comprising an extended recombinant polypeptide (XTEN) comprised of a plurality of overlapping sequence motifs and one or more barcode fragments releasable upon protease digestion and detectable from ail other proteolytic-ally releasable fragments. Certain embodiments of these polypeptides further comprise a biologically active polypeptide, wherein advantageous embodiments thereof comprise a releasable segment capable of proteolytic cleavage that cleaves the linkage between the XTEN polypeptide and the biologically active polypeptide. Methods of making and methods of using said polypeptides are also disclosed.Type: ApplicationFiled: November 13, 2020Publication date: September 14, 2023Inventors: Volker SCHELLENBERGER, Eric JOHANSEN, Angela HENKENSIEFKEN
-
Publication number: 20230265146Abstract: The present invention relates to compositions comprising biologically active proteins, such as cytokines, linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of related disorders and conditions.Type: ApplicationFiled: December 2, 2022Publication date: August 24, 2023Inventors: Volker SCHELLENBERGER, Eric JOHANSEN, Angela HENKENSIEFKEN, Bryan IRVING, Tracy YOUNG, Vibha CHAUHAN, Valentine YEUNG
-
Publication number: 20230200487Abstract: Implementations disclosed herein provide for shoes including one or more wave cushions that provide temporary storage of the shoes’ impact energy with the ground and return of a portion of that energy to enhance a runner’s running economy. The wave cushions may include a pair of foundation layers, each with an engagement surface and a sinusoidal sectional profile. The sinusoidal sectional profiles are phase offset, and the elastic membrane is oriented between the engagement surfaces. The engagement surfaces together act as alternating matched pairs of actuators and cavities. Each actuator stretches a portion of the elastic membrane into a cavity when a runner’s weight is applied, converting the runner’s kinetic energy to potential energy stored in the stretched and deformed elastic membrane. As the runner’s weight is removed, the elastic membrane springs back into a substantially planar orientation, transferring the stored potential energy back to the runner as kinetic energy.Type: ApplicationFiled: December 22, 2022Publication date: June 29, 2023Inventors: Zenon Oleg Smotrycz, Eric Johansen Clement, Arthur Robert Taylor
-
Patent number: 11484040Abstract: The present invention relates to mutants of lactic acid bacteria which are resistant to the antibiotic ampicillin and which were found to give an increased texture when grown in milk while maintaining the other growth properties of the parent strain. The present invention, furthermore, relates to compositions comprising such mutants, and to dairy products fermented with the lactic acid bacteria resistant to ampicillin.Type: GrantFiled: June 3, 2019Date of Patent: November 1, 2022Assignee: Chr. Hansen A/SInventors: Eric Johansen, Kim Ib Soerensen, Annette Kibenich
-
Publication number: 20220061348Abstract: The dairy industry today faces a problem of providing an alternative to adding sweeteners to fermented milk products in order to achieve the desired sweet taste without the added calories. Furthermore, it would be highly advantageous to establish a method for reducing lactose in fermented milk products to a level which is acceptable for lactose-intolerant consumers. The above problems have been solved by providing mutant Streptococcus thermophilus strains and mutant Lactobacillus delbrueckii subsp. bulgaricus strains that excrete glucose to the milk when the milk is inoculated and fermented with such Streptococcus thermophilus strains and Lactobacillus delbrueckii subsp, bulgaricus strains.Type: ApplicationFiled: July 30, 2021Publication date: March 3, 2022Applicant: Chr. Hansen A/SInventors: Eric JOHANSEN, Kim Ib SOERENSEN, Mirjana CURIC-BAWDEN, Mette Pia JUNGE
-
Patent number: 11076609Abstract: Described are mutant Streptococcus thermophilus strains and mutant Lactobacillus delbrueckii subsp. bulgaricus strains that excrete glucose into milk when the milk is inoculated and fermented with such strains. Methods for obtaining such strains without genetic modification are described, including methods for obtaining such Streptococcus thermophilus strains by selecting and isolating from a pool of Streptococcus thermophilus strains derived from a galactose-fermenting Streptococcus thermophilus mother strain a pool of Streptococcus thermophilus strains which are resistant to 2-deoxyglucose, and selecting and isolating from the pool of Streptococcus thermophilus strains which are resistant to 2-deoxyglucose a Streptococcus thermophilus strain which exhibits a growth rate in M17 medium+2% galactose higher than its growth rate in M17 medium+2% glucose. The strains are useful for decreasing the lactose content of a fermented food product and for boosting growth of the probiotic BB-12®.Type: GrantFiled: October 17, 2019Date of Patent: August 3, 2021Assignee: CHR. HANSEN A/SInventors: Eric Johansen, Kim Ib Soerensen, Mirjana Curic-Bawden, Mette Pia Junge
-
Patent number: 11044920Abstract: The dairy industry today faces a problem of providing an alternative to adding sweeteners to fermented milk products in order to achieve the desired sweet taste without the added calories. Furthermore, it would be highly advantageous to establish a method for reducing lactose in fermented milk products to a level which is acceptable for lactose-intolerant consumers. The above problems have been solved by providing mutant Streptococcus thermophilus strains and mutant Lactobacillus delbrueckii subsp. bulgaricus strains that excrete glucose to the milk when the milk is inoculated and fermented with such Streptococcus thermophilus strains and Lactobacillus delbrueckii subsp, bulgaricus strains.Type: GrantFiled: April 25, 2013Date of Patent: June 29, 2021Assignee: CHR. HANSEN A/SInventors: Eric Johansen, Kim Ib Soerensen, Mirjana Curic-Bawden, Mette Pia Junge
-
Patent number: 10716313Abstract: The present invention relates to mutants of lactic acid bacteria which are resistant to the antibiotic ampicillin and which were found to give an increased texture when grown in milk while maintaining the other growth properties of the parent strain. The present invention, furthermore, relates to compositions comprising such mutants, and to dairy products fermented with the lactic acid bacteria resistant to ampicillin.Type: GrantFiled: April 23, 2013Date of Patent: July 21, 2020Assignee: CHR. HANSEN A/SInventors: Eric Johansen, Kim Ib Soerensen, Annette Kibenich
-
Patent number: 10702560Abstract: A Bacillus strain characterized by (i): sensitivity for ampicillin, vancomycin, gentamicin, kanamycin, streptomycin, erythromycin, clindamycin, tetracycline and chloramphenicol antimicrobial activity against E. coli and Clostridium perfringens; and (iii) a sporulation percentage of at least 80 when measured after 2 days of incubation. The invention further relates to a method for selecting such strains. Many of the identified strains according to the invention are of the species Bacillus amyloliquefaciens. Some of the Bacillus amyloliquefaciens were further identified as Bacillus amyloliquefaciens subsp. amyloliquefaciens whereas others were identified as amyloliquefaciens subsp. plantarum. A Bacillus strain of the invention may be used as a feed additive to animal feed where it has a probiotic effect.Type: GrantFiled: December 8, 2017Date of Patent: July 7, 2020Assignee: CHR. HANSEN A/SInventors: Beatrice Nielsen, Mette Dines Cantor, Birgitte Stuer-Lauridsen, Patrick Derkx, Eric Johansen
-
Publication number: 20200093149Abstract: The dairy industry today faces a problem of providing an alternative to adding sweeteners to fermented milk products in order to achieve the desired sweet taste without the added calories. Furthermore, it would be highly advantageous to establish a method for reducing lactose in fermented milk products to a level which is acceptable for lactose-intolerant consumers. The above problems have been solved by providing mutant Streptococcus thermophilus strains and mutant Lactobacillus delbrueckii subsp. bulgaricus strains that excrete glucose to the milk when the milk is inoculated and fermented with such Streptococcus thermophilus strains and Lactobacillus delbrueckii subsp, bulgaricus strains.Type: ApplicationFiled: October 17, 2019Publication date: March 26, 2020Applicant: Chr. Hansen A/SInventors: Eric JOHANSEN, Kim Ib SOERENSEN, Mirjana CURIC-BAWDEN, Mette Pia JUNGE
-
Publication number: 20190281847Abstract: The present invention relates to mutants of lactic acid bacteria which are resistant to the antibiotic ampicillin and which were found to give an increased texture when grown in milk while maintaining the other growth properties of the parent strain. The present invention, furthermore, relates to compositions comprising such mutants, and to dairy products fermented with the lactic acid bacteria resistant to ampicillin.Type: ApplicationFiled: June 3, 2019Publication date: September 19, 2019Applicant: Chr. Hansen A/SInventors: Eric Johansen, Kim Ib Soerensen, Annette Kibenich
-
Patent number: 10392597Abstract: The present invention relates to mutants of lactic acid bacteria which are resistant towards the antibiotic D-cycloserine and/or functionally equivalent antibiotics and which were found to give an increased texture when grown in milk while maintaining the other growth properties of the parent strain. The present invention, furthermore, relates to compositions comprising such mutants, and to dairy products fermented with the lactic acid bacteria resistant towards D-cycloserine and/or functionally equivalent antibiotics.Type: GrantFiled: September 21, 2016Date of Patent: August 27, 2019Assignee: Chr. Hanse A/SInventors: Annette Kibenich, Kim Ib Soerensen, Eric Johansen
-
Publication number: 20180200309Abstract: A Bacillus strain characterized by (i): sensitivity for ampicillin, vancomycin, gentamicin, kanamycin, streptomycin, erythromycin, clindamycin, tetracycline and chloramphenicol antimicrobial activity against E. coli and Clostridium perfringens; and (iii) a sporulation percentage of at least 80 when measured after 2 days of incubation. The invention further relates to a method for selecting such strains. Many of the identified strains according to the invention are of the species Bacillus amyloliquefaciens. Some of the Bacillus amyloliquefaciens were further identified as Bacillus amyloliquefaciens subsp. amyloliquefaciens whereas others were identified as amyloliquefaciens subsp plantarum. A Bacillus strain of the invention may be used as a feed additive to animal feed where it has a probiotic effect.Type: ApplicationFiled: December 8, 2017Publication date: July 19, 2018Applicant: Chr. Hansen A/SInventors: Beatrice Nielsen, Mette Dines Cantor, Birgitte Stuer-Lauridsen, Patrick Derkx, Eric Johansen
-
Patent number: 9891203Abstract: Systems and methods are provided for detecting host cell contaminants in a protein biotherapeutic product using sequential windowed acquisition tandem mass spectrometry. Sequential windowed acquisition is performed on a protein biotherapeutic product sample by sequentially stepping a precursor mass window across a mass range, fragmenting transmitted precursor ions of each stepped precursor mass window, and analyzing product ions produced from the fragmented transmitted precursor ions. The sequential windowed acquisition is performed without any information about contaminating proteins before data acquisition, and produces data for every product ion of every transmitted precursor ion for the mass range. One or more measured product ion spectra are received, and compared to a library of host cell proteins. One or more host cell contaminants are detected by reporting host cell proteins from the library that match the one or more measured product ion spectra.Type: GrantFiled: June 3, 2014Date of Patent: February 13, 2018Assignee: DH Technologies Development Pte. Ltd.Inventor: Eric Johansen
-
Patent number: 9844573Abstract: A Bacillus strain characterized by (i): sensitivity for ampicillin, vancomycin, gentamicin, kanamycin, streptomycin, erythromycin, clindamycin, tetracycline and chloramphenicol; (ii) antimicrobial activity against E. coli and Clostridium perfringens; and (iii) a sporulation percentage of at least 80 when measured after 2 days of incubation. The invention further relates to a method for selecting such strains. Many of the identified strains according to the invention are of the species Bacillus amyloliquefaciens. Some of the Bacillus amyloliquefaciens were further identified as Bacillus amyloliquefaciens subsp. amyloliquefaciens whereas others were identified as amyloliquefaciens subsp. plantarum. A Bacillus strain of the invention may be used as a feed additive to animal feed where it has a probiotic effect.Type: GrantFiled: April 11, 2013Date of Patent: December 19, 2017Assignee: CHR. HANSEN A/SInventors: Beatrice Nielsen, Mette Dines Cantor, Birgitte Stuer-Lauridsen, Patrick Derkx, Eric Johansen
-
Publication number: 20170009198Abstract: The present invention relates to mutants of lactic acid bacteria which are resistant towards the antibiotic D-cycloserine and/or functionally equivalent antibiotics and which were found to give an increased texture when grown in milk while maintaining the other growth properties of the parent strain. The present invention, furthermore, relates to compositions comprising such mutants, and to dairy products fermented with the lactic acid bacteria resistant towards D-cycloserine and/or functionally equivalent antibiotics.Type: ApplicationFiled: September 21, 2016Publication date: January 12, 2017Applicant: CHR. HANSEN A/SInventors: Annette KIBENICH, Kim Ib SOERENSEN, Eric JOHANSEN
-
Patent number: 9469831Abstract: Cycloserine resistant mutants of lactic acid bacteria characterized by having improved resistance towards ethanol. The cycloserine resistant mutants of lactic acid bacteria can e.g. be used for malolactic fermentations of wine (i.e. including sparkling wine such as Cava/champagne) having high alcohol levels.Type: GrantFiled: June 14, 2012Date of Patent: October 18, 2016Assignee: Chr. Hansen A/SInventors: Kim Ib Soerensen, Annette Kibenich, Eric Johansen
-
Patent number: 9453231Abstract: The present invention relates to mutants of lactic acid bacteria which are resistant towards the antibiotic D-cycloserine and/or functionally equivalent antibiotics and which were found to give an increased texture when grown in milk while maintaining the other growth properties of the parent strain. The present invention, furthermore, relates to compositions comprising such mutants, and to dairy products fermented with the lactic acid bacteria resistant towards D-cycloserine and/or functionally equivalent antibiotics.Type: GrantFiled: October 21, 2011Date of Patent: September 27, 2016Assignee: Chr. Hansen A/SInventors: Annette Kibenich, Kim Ib Soerensen, Eric Johansen