Patents by Inventor Eric Josephs

Eric Josephs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF IMPROVING SPECIFICITY IN GENOMIC ENGINEERING USING RNA-GUIDED ENDONUCLEASES
    Publication number: 20230304000
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) and methods of designing and using said optimized gRNAs that have increased target binding specificity and reduced off-target binding.
    Type: Application
    Filed: August 26, 2022
    Publication date: September 28, 2023
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach
  • COMPOSITIONS AND METHODS OF IMPROVING SPECIFICITY IN GENOMIC ENGINEERING USING RNA-GUIDED ENDONUCLEASES
    Publication number: 20230047669
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs.
    Type: Application
    Filed: August 2, 2022
    Publication date: February 16, 2023
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach
  • Compositions and methods of improving specificity in genomic engineering using RNA-guided endonucleases
    Patent number: 11427817
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) that have increased target binding specificity and reduced off-target binding. Further disclosed herein are methods of designing and using the optimized gRNAs.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 30, 2022
    Assignee: Duke University
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach
  • POLYVALENT GUIDE RNAS FOR CRISPR ANTIVIRALS
    Publication number: 20220204970
    Abstract: Generally, the present disclosure is directed to methods for gRNA design and products thereof that can be used as antivirals in which the produced gRNAs can be tolerant to polymorphisms across clinical strains and/or adapted for activity at multiple viral sites. Aspects of example gRNAs can also include reduced interactions with the human genome or transcriptome.
    Type: Application
    Filed: December 20, 2021
    Publication date: June 30, 2022
    Inventor: Eric JOSEPHS
  • COMPOSITIONS AND METHODS OF IMPROVING SPECIFICITY IN GENOMIC ENGINEERING USING RNA-GUIDED ENDONUCLEASES
    Publication number: 20190136229
    Abstract: Disclosed herein are optimized guide RNAs (gRNAs) and methods of designing and using said optimized gRNAs that have increased target binding specificity and reduced off-target binding.
    Type: Application
    Filed: August 25, 2016
    Publication date: May 9, 2019
    Inventors: Eric Josephs, Dewran Kocak, Piotr Marszalek, Charles A. Gersbach