Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of multiple myeloma. In particular, the present invention relates to a method of treating multiple myeloma in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a SETD8 inhibitor.

Abstract: Configuration of a new point code connected to a SS7 network through a MTP level 3 aligned link, involves listening to point code status massages originating from distant point codes and forwarded on said link. When a message originating from an unknown distant point code is received, the table of distant point codes is updated with the point code number of the distant point code; at the same time, a primary route to the new distant point code through the link may be created. Therefore, configuration and testing of a new point code within an existing SS7 network, without having to re-enter the full network architecture, is facilitated.

Abstract: According to a first aspect of the present invention, there is provided a method of processing a signaling message received from a service application and intended for delivery to a network element having a point code, comprising retrieving, from a data store, an indication of the network type associated with the point code and processing the signaling message through one of a plurality of protocol stack layers in accordance with the retrieved network type.

Abstract: The invention provides, among other things, regulated polymerase III expression systems and related compositions. The invention provides, in part, expression systems in which the expression is inducible, and systems which express inhibitory RNA molecules, such as hairpin RNA molecules. The invention also provides related methods, such as methods of inhibiting expression of a gene.

Abstract: The invention relates to Common Channel Signalling systems, such as SS7. For improving configuration of a new point code connected to a SS7 network through a MTP level 3 aligned link, the invention suggests listening to point code status messages originating from distant point codes and forwarded on said link. When a message originating from an unknown distant point code is received, the table of distant point codes is updated with the point code number of the distant point code; at the same time, a primary route to the new distant point code through the link may be created. The invention makes it possible to configure and test a new point code within an existing SS7 network, without having to re-enter the full network architecture.

Abstract: A device for executing informatic procedures, including activities of end of day and/or data safety procedures, for data processing systems, includes at least one component for requesting the starting of data processing procedures. The device further includes a storing and processing component adapted to receive a procedure starting request signal output from the request component. The storing and processing component is adapted to command the procedures be automatically executed and to drive supply cut-off elements for automatically cutting off the supply to all or part of at least one of the data processing systems at the end of the procedures.