Patents by Inventor Eric Kelsic

Eric Kelsic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Library-scale engineering of metabolic pathways
    Patent number: 11939571
    Abstract: Expressing guide nucleic acids (e.g., gRNA) from the same oligonucleotide that contains donor sequence permits the high efficiency, simultaneous transformation of a population of cells with both substrates. Using oligonucleotide chip array technology, one can construct thousands of oligonucleotides with customized gRNA and donor sequence in a cost effective manner. In combination, one can efficiently modify endogenous and exogenous genes.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: March 26, 2024
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Xiaoge Guo, Alejandro Chavez, Max Schubert, Eric Kelsic
  • IMPROVED DEPENDOPARVOVIRUS PRODUCTION COMPOSITIONS AND METHODS
    Publication number: 20230357324
    Abstract: The disclosure is directed in part to improved methods of making dependoparvovirus particles utilizing a nucleic acid comprising an open reading from encoding membrane-associated accessory protein (MAAP) comprising an exogenous start codon.
    Type: Application
    Filed: August 26, 2021
    Publication date: November 9, 2023
    Inventors: Jeffrey GEROLD, Eric KELSIC, Sam SINAI, Adrian VERES, Samuel WOLOCK
  • VIRAL CAPSID POLYPEPTIDES
    Publication number: 20230002451
    Abstract: The technology described herein provides variant adeno-associated viral capsid polypeptides and viruses comprising the same. Further provided herein are methods for delivering a viral payload using viruses comprising variant capsid polypeptides described herein.
    Type: Application
    Filed: November 6, 2020
    Publication date: January 5, 2023
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Eric KELSIC, Sam SINAI, Pierce OGDEN, George M. CHURCH
  • VIRAL CAPSID POLYPEPTIDES
    Publication number: 20220396808
    Abstract: The technology described herein provides variant adeno-associated viral capsid polypeptides and viruses comprising the same. Further provided herein are methods for delivering a viral payload using viruses comprising variant capsid polypeptides described herein. Described herein are viral vectors comprising a variant sequence of the capsid gene, VP1. In particular, viral vectors with capsid polypeptide mutations that modify tropism of the viral particles relative to particles with wild-type capsid polypeptide are described.
    Type: Application
    Filed: November 6, 2020
    Publication date: December 15, 2022
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Eric KELSIC, Sam SINAI, George M. CHURCH
  • VIRAL VECTORS EXHIBITING IMPROVED GENE DELIVERY PROPERTIES
    Publication number: 20210230229
    Abstract: The technology described herein provides viral capsid polypeptides bearing mutations that alters tissue tropism of a virus comprising the viral capsid polypeptide. In various embodiments, tissue tropisim to the heart, kidney, liver, lung, spleen, or blood is altered.
    Type: Application
    Filed: May 8, 2019
    Publication date: July 29, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: George M. CHURCH, Eric KELSIC, Pierce OGDEN, Sam SINAI
  • Library-scale Engineering of Metabolic Pathways
    Publication number: 20190264196
    Abstract: Expressing guide nucleic acids (e.g., gRNA) from the same oligonucleotide that contains donor sequence permits the high efficiency, simultaneous transformation of a population of cells with both substrates. Using oligonucleotide chip array technology, one can construct thousands of oligonucleotides with customized gRNA and donor sequence in a cost effective manner. In combination, one can efficiently modify endogenous and exogenous genes.
    Type: Application
    Filed: June 12, 2017
    Publication date: August 29, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Xiaoge Guo, Alejandro Chavez, Max Schubert, Eric Kelsic