Abstract: The present disclosure relates to an injection moulding machine for manufacturing injected permanent magnets, including: -a mould provided with an internal cavity; -a magnetisation device capable of applying a magnetic field inside the internal cavity of the mould; -at least one forming pin which is translatably movable with respect to the mould between a first position, referred to as an inoperative position, in which it is positioned entirely outside the mould, and a second position, referred to as an operative position, in which it is positioned inside the internal cavity of the mould; and -a demagnetisation device capable of removing any magnetisation from said at least one forming pin.

Abstract: The present disclosure relates to a stator for an electric motor, comprising: a stator body forming a ring extending along an axis between a front end face and a rear end face the stator body including an outer peripheral face and an inner peripheral face provided with teeth the teeth defining, in pairs, a plurality of notches open towards the inside of the stator body; a plurality of conductor segments inserted at least partially into the notches of the stator body; wherein the stator body is provided with at least one internal cavity, the at least one internal cavity housing at least one sound-absorbing or structural damping element, the at least one sound-absorbing or structural damping element being able to attenuate the vibrations and/or mechanical and/or magnetic noises generated by the stator during its operation within the electric motor.

Abstract: The present disclosure relates to a rotor for an electric motor, including: —a rotor shaft mounted so as to rotate about an axis; —a stack of laminations mounted coaxially on the rotor shaft, said stack of laminations including internal cavities housing permanent magnets; —a front flange and a rear flange mounted coaxially on the rotor shaft and arranged axially on either side of the stack of laminations so as to be contiguous with the front and rear side faces, respectively, of the stack of laminations; —flow channels for a cooling fluid, which are formed respectively inside the shaft, the front and rear flanges, and the permanent magnets.

Abstract: The disclosure provides a guide RNA (gRNA) comprising a DNA-binding domain and a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease protein-binding domain, wherein the DNA-binding domain is complementary to a target domain from an NRF2 gene. The disclosure also provides nucleic acid sequence encoding the gRNA. The disclosure further provides a method of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease and a guide RNA that is complementary to a target domain from an NRF2 gene in the subject.

Abstract: The disclosure provides a guide RNA (gRNA) comprising a DNA-binding domain and a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease protein-binding domain, wherein the DNA-binding domain is complementary to a target domain from a variant NRF2 gene found in a cancer cell but not in a non-cancerous cell. The disclosure also provides nucleic acid sequence encoding the gRNA. The disclosure further provides a method of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease and a guide RNA that is complementary to a target domain from a variant NRF2 gene in the subject.

Abstract: The present invention provides a computer-implemented educational management system that empowers educators to create new student-centric guided pathways that help increase college readiness, accelerate college completion and improve student outcomes and career readiness for all, throughout our education system. By providing all the key college touchpoints throughout the students' journey and guiding them every step of their college experience, the present invention enables colleges to keep students on track and prepares them for successful entry into the workforce. The present invention further facilitates labor market readiness through employer-education linkages and by seamlessly connecting students to workforce opportunities. The present invention further provides comprehensive practitioner dashboards that enables the secure and consistent alignment, collection and real-time reporting of key performance accountability metrics for various state and federal programs.

Abstract: The disclosure provides a guide RNA (gRNA) comprising a DNA-binding domain and a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease protein-binding domain, wherein the DNA-binding domain is complementary to a target domain from a variant NRF2 gene found in a cancer cell but not in a non-cancerous cell. The disclosure also provides nucleic acid sequence encoding the gRNA. The disclosure further provides a method of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease and a guide RNA that is complementary to a target domain from a variant NRF2 gene in the subject.

Abstract: The disclosure provides a guide RNA (gRNA) comprising a DNA-binding domain and a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease protein-binding domain, wherein the DNA-binding domain is complementary to a target domain from an NRF2 gene. The disclosure also provides nucleic acid sequence encoding the gRNA. The disclosure further provides a method of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease and a guide RNA that is complementary to a target domain from an NRF2 gene in the subject.

Abstract: Presently described is a guanosine-rich polynucleotide molecule with therapeutic utility for treating or preventing the growth of cancerous cells. In addition, a method of retarding cell cycle progression and inducing apoptosis in tumor cells using synthetic oligonucleotides is also described.

Abstract: The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions.

Abstract: Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration in vivo, ex vivo and in vitro are presented. These methods and compositions involve cells and cell-free extracts with altered levels or activities of a protein from the RAD52 epistasis group, the mismatch repair group and/or the excision repair group.

Abstract: The present invention relates to oligonucleotide compositions and therapeutic uses thereof to modify protein-protein interactions.

Abstract: Methods, kits and cell lines are presented for effecting oligonucleotide-directed genetic alteration at a specific locus in a target DNA molecule in a population of cells at increased efficiency.

Abstract: Methods for the production and use of stable complexes of duplex nucleic acid molecules and oligonucleotides are presented. These complexes can be used for the detection and purification of a known nucleic acid target as well as the manipulation of a defined nucleic acid target sequence.