Abstract: An integrated system for processing and using images acquired of subjects in a research or clinical environment is provided. The integrated system includes an image and data bank, a workflow management module, a cloud storage module and a pre-processing module. The pre-processing engine is positioned between the workflow management module and the cloud storage module and is configured to receive raw images, data associated with the raw images and the data associated with the imaged subjects from the workflow management module and process this data and provide the processed data to be pushed into the cloud storage module. The pre-processing engine also anonymizes the data to provide de-identified images and data to the cloud storage module and creates a key that relates the raw images, data associated with the raw images and the data associated with the imaged subjects to the de-identified, processed images and data. The key remains separate and un-connected from the de-identified, processed images and data.

Abstract: A method for segmenting images is provided including tessellating an image obtained from one of an image database and an imaging system into a plurality of sectors; classifying each of the plurality of sectors by applying one or more pre-defined labels to each of the plurality of sectors, wherein the pre-defined labels indicate at least one of an image quality metric (IQM) and a metric of structure; assigning each of the plurality of classified sectors an Image Quality Classification (IQC); identifying anchor sectors among the plurality of classified sectors, applying filtering and edge detection to identify target boundaries; applying contouring across contiguous sectors and using the assigned IQC as a guide to complete segmentation of an edge between any two identified anchor sectors; and smoothing across segmented regions to increase parametric second-order continuity.

Abstract: A method for segmenting images is provided including tessellating an image obtained from one of an image database and an imaging system into a plurality of sectors; classifying each of the plurality of sectors by applying one or more pre-defined labels to each of the plurality of sectors, wherein the pre-defined labels indicate at least one of an image quality metric (IQM) and a metric of structure; assigning each of the plurality of classified sectors an Image Quality Classification (IQC); identifying anchor sectors among the plurality of classified sectors, applying filtering and edge detection to identify target boundaries; applying contouring across contiguous sectors and using the assigned IQC as a guide to complete segmentation of an edge between any two identified anchor sectors; and smoothing across segmented regions to increase parametric second-order continuity.

Abstract: Methods are provided for performing a surgical procedure using optical coherence tomography (OCT) including extracting lenticular material from within a capsular bag of the eye of a patient; placing a replacement lens within the capsular bag after extraction of the lenticular material from the capsular bag; acquiring a plurality of OCT images that visualize the placement of the replacement lens within the capsular bag; and determining from the plurality of OCT images a degree of contact of the posterior surface of the replacement lens with the posterior portion of the capsular bag.

Abstract: An application programming interface (API) resident on a computer is provided that, upon receiving a message that a data set associated with an encounter experienced by a subject is available, causes a processor to read a structured file associated with the data set, the structured file having a set of records assigned to a subset of pre-defined fields and a location of one or more unstructured objects, the pre-defined fields being organized according to an ontology having at least records related to the subject, the encounter and the data set; and populate at least first and second independent and distinct relational databases using endpoints of the API. The first relational database excludes records associated with the subject and the encounter and the second relational database includes records associated with the subject and the encounter. The second relational database includes multiple tables that can be accessed by invoking the API.

Abstract: A low-coherence interferometry imaging system for imaging translucent samples, wherein the system includes an optical coherence microscopy (OCM) mode and an optical coherence tomography (OCT) mode, and wherein the system can selectively employ either mode without requiring re-positioning of a sample under test. The system provides for the selective disposition of the OCM mode or the OCT mode in an optical path intermediate a scanning system and an imaging objective.

Abstract: Surgical microscopes are provided including at least one ocular, an objective lens; a collimated space between the at least one ocular and the objective lens; an illumination system optically coupled into the collimated space of the surgical microscope, wherein an illumination from the illumination system is directed along a path at least partially contained within the collimated space of the surgical microscope and through the objective lens; and one of a field diaphragm and obscuration mask positioned within the illumination system, and outside of a field of view of the at least one ocular, wherein the one of the field diaphragm and the obscuration mask blocks, attenuates or diverts rays from the illumination system that reflect from a surface of the objective lens such that the reflected rays are not visible through the at least one ocular.

Abstract: A model eye for calibrating a retinal imaging system is provided including a backplane having a negative radius of curvature R centered on the optical axis and a clear aperture diameter D2; a distance h along the optical axis from the nodal point to the backplane; an unobstructed field of view 2?; a closed fluid fillable housing; a mechanical system for mounting, aligning, and preserving spacings of the elements of the model eye; and a pattern applied to the backplane, the pattern having a rotational symmetry and a radial repeating unit, extending substantially across the clear aperture, that spatially modulates intensity of light reflected from, or transmitted through, a surface of the backplane. D2/D1 is greater than 2, an absolute value of R/h is greater than 0.5, and 2? is greater than zero (0) degrees.

Abstract: Integrated systems for collecting, storing, and distribution of images acquired of subjects in a research or clinical environment are provided. The system includes an image and data repository including a plurality of images originating from one or more image-generating devices, data associated with the images, and data associated with imaged subjects; and a workflow management module in direct communication with the image and data repository and with the one or more image-generating devices and/or storage devices that store the images of the imaged subjects, the workflow management module being configured to transport the images directly from the one or more image-generating devices and/or storage devices to the image and data repository and to manage the collation and distribution of images, data associated with the raw images and the data associated with the imaged subjects in the image and data repository.

Abstract: Methods are provided for performing a surgical procedure using optical coherence tomography (OCT) including extracting lenticular material from within a capsular bag of the eye of a patient; placing a replacement lens within the capsular bag after extraction of the lenticular material from the capsular bag; acquiring a plurality of OCT images that visualize the placement of the replacement lens within the capsular bag; and determining from the plurality of OCT images a degree of contact of the posterior surface of the replacement lens with the posterior portion of the capsular bag.

Abstract: Systems for determining an apex of curvature In an image, obtained from, a sample are provided. The systems include—an imaging system configured to obtain a plurality of scans of a sample using a radial pattern; and a processor associated with the imaging system. The processor is configured to segment and curve fit each of the plurality of scans to a surface of the sample; determine an apex. for each curve associated with each of the plurality of scans; determine a true apex, among all determined apexes using a derivative of least value; calculate an XY offset based on the determined true apex; map the true apex to an origin where X and Y are equal to zero; and adjust the coordinates associated with remaining apexes not determined to be the true apex based on the calculated offset.

Abstract: An integrated system for processing and using images acquired of subjects in a research or clinical environment is provided. The integrated system includes an image and data bank, a workflow management module, a cloud storage module and a pre-processing module. The pre-processing engine is positioned between the workflow management module and the cloud storage module and is configured to receive raw images, data associated with the raw images and the data associated with the imaged subjects from the workflow management module and process this data and provide the processed data to be pushed into the cloud storage module. The pre-processing engine also anonymizes the data to provide de-identified images and data to the cloud storage module and creates a key that relates the raw images, data associated with the raw images and the data associated with the imaged subjects to the de-identified, processed images and data. The key remains separate and un-connected from the de-identified, processed images and data.

Abstract: A method for segmenting images is provided including tessellating an image obtained from one of an image database and an imaging system into a plurality of sectors; classifying each of the plurality of sectors by applying one or more pre-defined labels to each of the plurality of sectors, wherein the pre-defined labels indicate at least one of an image quality metric (IQM) and a metric of structure; assigning each of the plurality of classified sectors an Image Quality Classification (IQC); identifying anchor sectors among the plurality of classified sectors, applying filtering and edge detection to identify target boundaries; applying contouring across contiguous sectors and using the assigned IQC as a guide to complete segmentation of an edge between any two identified anchor sectors; and smoothing across segmented regions to increase parametric second-order continuity.

Abstract: Integrated systems for collecting, storing, and distribution of images acquired of subjects in a research or clinical environment are provided. The system includes an image and data repository including a plurality of images originating from one or more image-generating devices, data associated with the images, and data associated with imaged subjects; and a workflow management module in direct communication with the image and data repository and with the one or more image-generating devices and/or storage devices that store the images of the imaged subjects, the workflow management module being configured to transport the images directly from the one or more image-generating devices and/or storage devices to the image and data repository and to manage the collation and distribution of images, data associated with the raw images and the data associated with the imaged subjects in the image and data repository.

Abstract: Methods are provided for performing a surgical procedure using optical coherence tomography (OCT) including extracting lenticular material from within a capsular bag of the eye of a patient; placing a replacement lens within the capsular bag after extraction of the lenticular material from the capsular bag; acquiring a plurality of OCT images that visualize the placement of the replacement lens within the capsular bag; and determining from the plurality of OCT images a degree of contact of the posterior surface of the replacement lens with the posterior portion of the capsular bag.

Abstract: Surgical microscopes are provided including at least one ocular, an objective lens; a collimated space between the at least one ocular and the objective lens; an illumination system optically coupled into the collimated space of the surgical microscope, wherein an illumination from the illumination system is directed along a path at least partially contained within the collimated space of the surgical microscope and through the objective lens; and one of a field diaphragm and obscuration mask positioned within the illumination system, and outside of a field of view of the at least one ocular, wherein the one of the field diaphragm and the obscuration mask blocks, attenuates or diverts rays from the illumination system that reflect from a surface of the objective lens such that the reflected rays are not visible through the at least one ocular.

Abstract: Methods are provided including obtaining at least one image of a surgical region of a subject oriented for the surgical procedure using an OCT imaging system. An initial structural view of the surgical region to be used during the surgical procedure is constructed based on the obtained at least one OCT image. Parameters are computed as an end point for assessing an outcome of the surgical procedure using data derived from the OCT image. The surgical procedure is periodically assessed and clinical outcomes are monitored using changes to the OCT-derived initial structural view of the surgical region or changes to the computed at least one clinical parameter. It is determined if the surgical plan needs modification and it is modified during the surgical procedure. Operations repeat until it is determined that no more modifications are needed.

Abstract: Field diaphragms for use in surgical microscopes are provided. The field diaphragms are positioned along an optical axis of a microscope illumination system. The field diaphragms include a frame portion configured to be received by the surgical microscope; and a non-circularly symmetric mask portion integrated with the frame portion. The mask portion is aligned such that marginal rays from an edge of the field diaphragm along a meridian of minimum diameter that reflect from a surface of an objective lens of the microscope reflect outside of an acceptance angle for relay through any ocular channel of the microscope.

Abstract: Methods are provided including obtaining at least one image of a surgical region of a subject oriented for the surgical procedure using an OCT imaging system. An initial structural view of the surgical region to be used during the surgical procedure is constructed based on the obtained at least one OCT image. Parameters are computed as an end point for assessing an outcome of the surgical procedure using data derived from the OCT image. The surgical procedure is periodically assessed and clinical outcomes are monitored using changes to the OCT-derived initial structural view of the surgical region or changes to the computed at least one clinical parameter. It is determined if the surgical plan needs modification and it is modified during the surgical procedure. Operations repeat until it is determined that no more modifications are needed.

Abstract: A model eye for use with an imaging system is provided. The model eye includes a shape that mimics a shape of a real eye of a subject and focal parameters of the real eye of the subject. The model eye is positioned in the imaging system in place of the real eye to assess and/or calibrate the imaging system. Related methods, systems and devices are also provided herein.