Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Abstract: Process for preparing metyrapone type compounds are generally described herein. In particular, one step process for preparing metyrapone type compounds are described herein. Such processes generally include an alpha-carbon arylation coupling reaction between 3-isobutyrylpyridine and 3-halopyridine compounds in the presence of a palladium catalyst and a phosphine ligand to form the metyrapone-type compounds.

Abstract: The invention relates to a novel method for the preparation of 4-phenyldibenzo[b,d]thiophene which can be conducted in one pot up to the thiophene ring formation. The synthesis is based upon dihalobenzenes and phenyllithium, which are readily obtainable, and can give higher yields (based upon either reactant) than the yields current methods, which use a synthetic pathway based upon dibenzo[b,d]thiophene.

Abstract: The invention relates to a novel method for the preparation of 4-phenyldibenzo[b,d]thiophene which can be conducted in one pot up to the thiophene ring formation. The synthesis is based upon dihalobenzenes and phenyllithium, which are readily obtainable, and can give higher yields (based upon either reactant) than the yields current methods, which use a synthetic pathway based upon dibenzo[b,d]thiophene.

Abstract: Process for preparing metyrapone type compounds are generally described herein. In particular, one step process for preparing metyrapone type compounds are described herein. Such processes generally include an alpha-carbon arylation coupling reaction between 3-isobutyrylpyridine and 3-halopyridine compounds in the presence of a palladium catalyst and a phosphine ligand to form the metyrapone-type compounds.

Abstract: A highly advantageous process for the preparation of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid or a salt thereof is described. The process comprises subjecting 1-acetyl 3-hydroxyadamantane to liquid phase oxidation with permanganate to produce 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid or a salt thereof, with acidification to form the free acid when appropriate.

Abstract: Roflumilast and new key intermediates therefor are prepared by processes involving use of carbonylation technology. Good overall yields can be achieved using available starting materials. The starting material for the process can be catechol, an o-R1-phenol, an o-R1-p-X-phenol, or a 1-X-3-R1-4-R2-benzene, where R1, is a C1-6 alkoxy, C3-7 cycloalkoxy, C3-7 cycloalkylmethoxy, or benzyloxy group, or a C1-4 alkoxy group which is completely or partially substituted by fluorine; R2 is a C1-4 alkoxy group which is completely or partially substituted by fluorine; and X is Cl, Br, or I.

Abstract: N-nitrosohydroxylamine compounds exhibiting minimal or no degradation are disclosed. The N-nitrosohydroxylamines can be stabilized in the presence of a compound capable of removing water from the environment.

Abstract: An improved process for the reaction of acetonitrile and hydrogen sulfide to produce thioacetamide, wherein a polymer-supported amine catalyst is used. Examples of the polymer-supported amine catalyst are polymeric dimethylaminopyridine resins, poly(4-vinylpyridine) cross-linked with divinylbenzene, and cross-linked polymer-supported 4-(N-benzyl-N-methylamino)pyridine.

Abstract: The disclosure herein relates to a new family of haloalkyl oxazolidinyl derivatives as antidotal compounds to reduce injury to crop plants by a variety of herbicides. The antidotal compounds are characterized particularly by having heterocyclyl or spiroheterocyclyl radicals attached to the 5-position of haloalkyl oxazolidine compounds and are especially useful as in-can antidotes against injury by acetanilide and thiocarbamate herbicides to corn, sorghum, soybeans, wheat, rice and other crops.

Abstract: The disclosure herein relates to a new family of haloalkyl oxazolidinyl derivatives as antidotal compounds to reduce injury to crop plants by a variety of herbicides. The antidotal compounds are characterized particularly by having heterocyclyl or spiroheterocyclyl radicals attached to the 5-position of haloalkyl oxazolidine compounds and are especially useful as in-can antidotes against injury by acetanilide and thiocarbamate herbicides to corn, sorghum, soybeans, wheat, rice and other crops.

Abstract: An optical cable comprises a plurality of separately formed flexible tubes in each of some or all of which is or are loosely housed at least one optical bundle and/or at least one seprate optical fibre. The plurality of tubes is surrounded by an outer protective sheath in which preferably they are so loosely housed as to permit limited relative movement between the tubes when the optical cable is flexed. Where the optical cable is likely to be subjected to a tensile force, preferably at least one elongate reinforcing member is embedded in or surrounded by the outer protective sheath.