Patents by Inventor Eric Lagasse

Eric Lagasse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220288127
    Abstract: The present invention relates to methods and compositions for transplanting non-lymphoid tissues into lymphoid organs. It may be used to cultivate organ tissues including for the purpose of supplementing or reconstituting organ function. Tissues that may be propagated in this manner include but are not limited to lung, kidney, thyroid, intestine, and brain.
    Type: Application
    Filed: October 29, 2021
    Publication date: September 15, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Eric Lagasse
  • Publication number: 20220152114
    Abstract: The present disclosure provides methods and kits for preserving or restoring thymic functions of a subject in need thereof. The methods and kits disclosed herein include delivering an autologous thymic tissue into at least one lymph node of the subject.
    Type: Application
    Filed: February 4, 2022
    Publication date: May 19, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Eric LAGASSE
  • Publication number: 20220096126
    Abstract: Provided herein are methods and systems of transplant cells and growing an ectopic tissue in a lymph node of a subject. In certain embodiments, the methods and systems provided herein enable minimally invasive cell transplantation to treat patients in need thereof In certain embodiments, the methods and systems provided herein include the use of ultrasound endoscopy.
    Type: Application
    Filed: October 11, 2021
    Publication date: March 31, 2022
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Eric LAGASSE, Paulo Artur CHAVES FONTES
  • Patent number: 11191785
    Abstract: The present invention relates to methods and compositions for transplanting non-lymphoid tissues into lymphoid organs. It may be used to cultivate organ tissues including for the purpose of supplementing or reconstituting organ function. Tissues that may be propagated in this manner include but are not limited to lung, kidney, thyroid, intestine, and brain.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: December 7, 2021
    Assignee: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Eric Lagasse
  • Publication number: 20190374583
    Abstract: The present disclosure relates to the engraftment and proliferation of cells in fat-associated lymphoid clusters (“FALCs” or “milky spots”), which may be used to generate functional ectopic tissue. The present disclosure further provides methods and compositions for grafting and proliferating cells, in FALCs by activating the lymphotoxin beta receptor (LT?R) and/or NF-?B-inducing kinase (NIK) signaling pathway. The present disclosure also provides for methods and compositions to establish ectopic liver tissue in FALCs (milky spots) and to use such ectopic liver tissue for therapeutic benefit, and provides methods and compositions to generate ectopic kidney tissue in FALCs, which can be used in a subject for therapeutic benefit.
    Type: Application
    Filed: August 16, 2019
    Publication date: December 12, 2019
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Eric Lagasse
  • Publication number: 20160058794
    Abstract: The present invention relates to methods and compositions for transplanting non-lymphoid tissues into lymphoid organs. It may be used to cultivate organ tissues including for the purpose of supplementing or reconstituting organ function. Tissues that may be propagated in this manner include but are not limited to lung, kidney, thyroid, intestine, and brain.
    Type: Application
    Filed: July 27, 2015
    Publication date: March 3, 2016
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Eric Lagasse
  • Patent number: 9125891
    Abstract: Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: September 8, 2015
    Assignee: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Eric Lagasse
  • Patent number: 8283164
    Abstract: A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell, for example, a cell population containing human liver engrafting cells wherein at least one cell in the population is HLAlow/neg; and expresses at least one marker selected from the group consisting of albumin; 5E12; Ep-Cam; CD49f; and E-Cadherin. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: October 9, 2012
    Assignee: StemCells, Inc.
    Inventors: Eric Lagasse, Timothy Austin
  • Publication number: 20110256625
    Abstract: A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.
    Type: Application
    Filed: August 10, 2010
    Publication date: October 20, 2011
    Inventors: Eric Lagasse, Timothy Austin
  • Publication number: 20110002899
    Abstract: Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.
    Type: Application
    Filed: March 9, 2009
    Publication date: January 6, 2011
    Inventor: Eric Lagasse
  • Patent number: 7811818
    Abstract: A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: October 12, 2010
    Assignee: StemCells, Inc.
    Inventors: Eric Lagasse, Timothy Austin
  • Publication number: 20100227393
    Abstract: Methods of preparing multipotent cell populations from gallbladder are provided. Also provided are enriched multipotent cell populations from gallbladder and methods of differentiating the multipotent cell populations to prepare, for example, hepatocytes.
    Type: Application
    Filed: March 5, 2010
    Publication date: September 9, 2010
    Inventor: Eric Lagasse
  • Patent number: 7211404
    Abstract: A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: May 1, 2007
    Assignee: Stem Cells, Inc.
    Inventors: Eric Lagasse, Timothy Austin
  • Publication number: 20070036774
    Abstract: A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.
    Type: Application
    Filed: August 9, 2006
    Publication date: February 15, 2007
    Inventors: Eric Lagasse, Timothy Austin
  • Publication number: 20030032184
    Abstract: A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.
    Type: Application
    Filed: June 21, 2002
    Publication date: February 13, 2003
    Inventors: Eric Lagasse, Timothy Austin
  • Publication number: 20010049139
    Abstract: Functional hepatic cells are generated from hematopoietic stem cells. In transplantation, populations of hematopoietic stem cells are shown to give rise to repopulating hepatocytes. The stem cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.
    Type: Application
    Filed: March 23, 2001
    Publication date: December 6, 2001
    Inventors: Eric Lagasse, Irving L. Weissman
  • Patent number: 5614397
    Abstract: Methods and compositions for modifying the lifespan of progeny cells of mammalian hematopoietic stem cells, particularly myeloid series cells, are provided. Transgenic nonhuman mammals also are provided which produce transgenic myeloid cells having an altered lifespan.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: March 25, 1997
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Irving Weissman, Eric Lagasse