Patents by Inventor Eric LeClerc
Eric LeClerc has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190093082Abstract: An object is to provide a method of differentiating pluripotent stem cells. A method of differentiating pluripotent stem cells, the method comprising steps of: seeding the pluripotent stem cells in a container provided with seeding medium! differentiating the pluripotent stem cells in the container; transferring the pluripotent stem cells from the container into a chamber of a bioreactor when the pluripotent stem cells reach their progenitor stage; and maturing the pluripotent stem cells in the chamber, wherein a floor of the chamber includes a concave and a convex, fluid of medium flows in the chamber and oxygen is supplied into the chamber.Type: ApplicationFiled: March 7, 2016Publication date: March 28, 2019Inventors: Eric Leclerc, Yasuyuki Sakai, Keiichi Kimura, Atsushi Miyajima, Taketomo Kido
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Patent number: 10119112Abstract: The present invention relates to a unit (1) comprising a microsystem (150) and at least one set of interface connections (16) for the microsystem (150); the microsystem (150) comprising a bottom plate (152) bearing the impression of at least one microstructured dynamic cell culture chamber (15), and a top plate (151), characterized in that the at least one microstructured chamber (15) is fluidically connected at inlet and/or at outlet by a set of connections (16) inserted removably into a hole in the upper plate (151). The present invention also relates to a dynamic cell culture system to this effect.Type: GrantFiled: March 2, 2011Date of Patent: November 6, 2018Assignees: Universite Technologie De Compiegne—UTC, Centre National de la Recherche Scientifique (CNRS)Inventors: Cécile Legallais, Régis Baudoin, Eric Leclerc, Jean-Matthieu Prot, Patrick Paullier
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Patent number: 9963669Abstract: The invention concerns a facility for coupling a bioreactor for culturing bio-organisms, in dynamic mode, with at least one device for physicochemically analyzing a fluid from this bioreactor or collecting samples of this fluid, the device being equipped with a pump and an injector, the bioreactor being equipped with means for supplying culture medium and xenobiotic(s). The facility is remarkable in that the bioreactor is connected to a closed perfusion loop provided with a pump, fitted with a sampling loop and in that the facility comprises: a device for injecting a cleaning product into said sampling loop, two six-way valves, the first valve being connected to the closed perfusion loop, to the sampling loop and to a cleaning loop, the second valve being connected to the cleaning loop and an injection loop that connects the injector to at least one of the devices.Type: GrantFiled: December 1, 2014Date of Patent: May 8, 2018Assignees: Universite Technologie De Compiegne—UTC, Centre National de la Recherche Scientifique (CNRS)Inventors: Eric Leclerc, Patrick Paullier, Franck Merlier
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Patent number: 9737864Abstract: The present invention relates to a method for producing microcapsules having a calibrated diameter and at least one parameter characteristic of the mechanical properties of an equally calibrated microcapsule, characterized in that the method includes the steps of: producing microcapsules by means of injection into a microsystem (10) of three fluids (f1, f2, f3); deforming the microcapsules by means generating a flow within a capillary tube (20); observing and acquiring the outline of at least one deformed microcapsule observed by an optical acquisition means (30); comparing the acquired outline with outlines from a collection of reference microcapsule outlines; determining the diameter and said at least one parameter characteristic of the mechanical properties of the observed microcapsule; and modifying the flow rates (Q1, Q2, and/or Q3) of the fluids (f1, f2, f3). The present invention also relates to a system for producing calibrated microcapsules.Type: GrantFiled: April 23, 2012Date of Patent: August 22, 2017Assignees: UNIVERSITE TECHNOLOGIE DE COMPIEGNE-UTC, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Eric Leclerc, Anne-Virginie Salsac, Dominique Barthes-Biesel, Thi Xuan Chu
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Publication number: 20170096629Abstract: The invention relates to a filtration device (100), characterized in that it includes: a first block (101) having a cavity forming a first chamber (110) comprising a bottom wall (111) having a set of microstructures including micro-walls and micro-contacts, the set of microstructures defining micro-chambers and micro-channels on the bottom wall (111) of the culture chamber; a second block (102) having a cavity forming a second chamber (120); and a filtration membrane (130), the first block (101), the membrane (130), and the second block (102) being arranged such that the membrane (130) is located between the first chamber (110) and the second chamber (120), adjacent to each of the first and second chambers (110, 120); as well as a first opening and a second opening for enabling a first fluid to pass into the second chamber (120) which is separated from the first chamber (110) by the membrane (130).Type: ApplicationFiled: December 16, 2016Publication date: April 6, 2017Inventors: Patrick Paullier, Aissa Ould Dris, Eric Leclerc
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Publication number: 20160304826Abstract: The invention concerns a facility for coupling a bioreactor for culturing bio-organisms, in dynamic mode, with at least one device for physicochemically analyzing a fluid from this bioreactor or collecting samples of this fluid, the device being equipped with a pump and an injector, the bioreactor being equipped with means for supplying culture medium and xenobiotic(s). The facility is remarkable in that the bioreactor is connected to a closed perfusion loop provided with a pump, fitted with a sampling loop and in that the facility comprises: a device for injecting a cleaning product into said sampling loop, two six-way valves, the first valve being connected to the closed perfusion loop, to the sampling loop and to a cleaning loop, the second valve being connected to the cleaning loop and an injection loop that connects the injector to at least one of the devices.Type: ApplicationFiled: December 1, 2014Publication date: October 20, 2016Applicants: Universite Technologie De Compiegne - UTC, Centre National de la Recherche Scientifique (CNRS )Inventors: Eric Leclerc, Patrick Paullier, Franck Merlier
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Patent number: 9448226Abstract: The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of theType: GrantFiled: May 12, 2011Date of Patent: September 20, 2016Assignees: Universite Technologie De Compiegne—UTC, Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Institut National De L'Environment Industriel Et Des RisquesInventors: Marc-Emmanuel Dumas, Eric Leclerc, Laetitia Shintu, Regis Baudoin, Cécile Legallais, Pierre Toulhoat, Céline Brochot
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Publication number: 20140191430Abstract: The present invention relates to a method for producing microcapsules having a calibrated diameter and at least one parameter characteristic of the mechanical properties of an equally calibrated microcapsule, characterized in that the method includes the steps of: producing microcapsules by means of injection into a microsystem (10) of three fluids (f1, f2, f3); deforming the microcapsules by means generating a flow within a capillary tube (20); observing and acquiring the outline of at least one deformed microcapsule observed by an optical acquisition means (30); comparing the acquired outline with outlines from a collection of reference microcapsule outlines; determining the diameter and said at least one parameter characteristic of the mechanical properties of the observed microcapsule; and modifying the flow rates (Q1, Q2, and/or Q3) of the fluids (f1, f2, f3). The present invention also relates to a system for producing calibrated microcapsules.Type: ApplicationFiled: April 23, 2012Publication date: July 10, 2014Inventors: Eric Leclerc, Anne-Virginie Salsac, Dominique Barthes-Biesel, Thi Xuan Chu
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Publication number: 20130084632Abstract: The present invention relates to a unit (1) comprising a microsystem (150) and at least one set of interface connections (16) for the microsystem (150); the microsystem (150) comprising a bottom plate (152) bearing the impression of at least one microstructured dynamic cell culture chamber (15), and a top plate (151), characterized in that the at least one microstructured chamber (15) is fluidically connected at inlet and/or at outlet by a set of connections (16) inserted removably into a hole in the upper plate (151). The present invention also relates to a dynamic cell culture system to this effect.Type: ApplicationFiled: March 2, 2011Publication date: April 4, 2013Applicants: CENTRE BENJAMIN FRANKLIN, UNIVERSITE TECHNOLOGIE DE COMPIEGNE - UTCInventors: Cécile Legallais, Régis Baudoin, Eric Leclerc, Jean-Matthieu Prot, Patrick Paullier
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Publication number: 20130060550Abstract: The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of theType: ApplicationFiled: May 12, 2011Publication date: March 7, 2013Applicants: UNIVERSITE TECHNOLOGIE DE COMPIEGNE - UTC, INSTITUT NATIONAL DE L'ENVIRONNEMENT INDUSTRIEL ET DES RISQUES, ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Marc-Emmanuel Dumas, Eric Leclerc, Laetitia Shintu, Regis Baudoin, Cécile Legallais, Pierre Toulhoat, Céline Brochot
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Publication number: 20130005027Abstract: The invention relates to a filtration device (100), characterized in that it includes: a first block (101) having a cavity forming a first chamber (110) comprising a bottom wall (111) having a set of microstructures including micro-walls and micro-contacts, the set of microstructures defining micro-chambers and micro-channels on the bottom wall (111) of the culture chamber; a second block (102) having a cavity forming a second chamber (120); and a filtration membrane (130), the first block (101), the membrane (130), and the second block (102) being arranged such that the membrane (130) is located between the first chamber (110) and the second chamber (120), adjacent to each of the first and second chambers (110, 120); as well as a first opening and a second opening for enabling a first fluid to pass into the second chamber (120) which is separated from the first chamber (110) by the membrane (130).Type: ApplicationFiled: September 23, 2010Publication date: January 3, 2013Inventors: Patrick Paullier, Aissa Ould Dris, Eric Leclerc
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Patent number: 8128126Abstract: A coupling device formed of two identical sides is disclosed. Each of the two sides have a snap fitting mechanism which engage each other to releasably secure the sides together thereby forming the coupling device. The coupling device as formed has a main body communicating with at least two openings. Each opening is sized to engage an end of a corresponding conduit. Generally, the conduits are corrugated such that the openings engage one corrugation to form the friction fit. The openings may be conically shaped with pre-scored cut lines that can be cut at different diameters to engage conduits of different diameters. The openings of the coupling device have pre-score cut lines that may be cut in order to create the friction fit with corrugated conduits having different diameters.Type: GrantFiled: July 16, 2007Date of Patent: March 6, 2012Assignee: IPEX Technologies Inc.Inventors: Timothy J. Poupore, Eric Leclerc Boutin, Younes Youssef
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Publication number: 20090021003Abstract: A coupling device formed of two identical sides is disclosed. Each of the two sides have a snap fitting mechanism which engage each other to releasably secure the sides together thereby forming the coupling device. The coupling device as formed has a main body communicating with at least two openings. Each opening is sized to engage an end of a corresponding conduit. Generally, the conduits are corrugated such that the openings engage one corrugation to form the friction fit. The openings may be conically shaped with pre-scored cut lines that can be cut at different diameters to engage conduits of different diameters. The openings of the coupling device have pre-score cut lines that may be cut in order to create the friction fit with corrugated conduits having different diameters.Type: ApplicationFiled: July 16, 2007Publication date: January 22, 2009Inventors: Timothy J. Poupore, Eric Leclerc Boutin, Younes Youssef
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Publication number: 20090005173Abstract: Embodiments of the present invention provide systems and methods for performing monitoring of gaming behaviour and applying remedies when the gaming behaviour is evaluated as being outside acceptable settings. A system is described wherein gaming machines are networked with a server housing databases and programs adapted to store player identifications, to store transactions, to determine when behaviour is outside acceptable settings and to signal a system component used by the identified player to apply a remedy. Also described are methods applied by the server and gaming system components are described in order to perform gaming behaviour monitoring and apply remedies when appropriate. Finally, there is described means and programs for players to provide acceptable gaming settings and remedies to be applied.Type: ApplicationFiled: June 9, 2008Publication date: January 1, 2009Applicant: Labtronix Concept Inc.Inventors: Denis BISSON, Andre Lapalme, Eric Leclerc, Yvan Paradis, Daniel Tougas
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Patent number: 5535604Abstract: Apparatus which is able to artificially produce wearing and fading of textile materials including an enclosure which is a barrel (1). This barrel is able to be placed into rotation around an axis (5), the barrel having an opening (6) which is equipped with a watertight door (7). The interior partitions (2) of the barrel are equipped with an abrasive lining (3), which includes protruding particles (12) and a stratified layer of these pieces.Type: GrantFiled: July 20, 1994Date of Patent: July 16, 1996Inventors: Antoine Rodrigues, Eric LeClerc
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Patent number: D573095Type: GrantFiled: April 25, 2007Date of Patent: July 15, 2008Assignee: IPEX Inc.Inventors: Timothy J. Poupore, Eric Leclerc Boutin