Abstract: As disclosed herein, ?-arrestin1 and ?-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both ?-arrestin1 and ?-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when ?-arrestin2 is overexpressed, tau levels become elevated. The data indicate that ?-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of ?-arrestin2. Therefore, disclosed herein are ?-arrestin oligomerization inhibitors that can be used to prevent ?-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a ?-arrestin oligomerization inhibitor disclosed herein.

Abstract: As disclosed herein, ?-arrestin1 and ?-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both ?-arrestin1 and ?-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when ?-arrestin2 is overexpressed, tau levels become elevated. The data indicate that ?-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of ?-arrestin2. Therefore, disclosed herein are ?-arrestin oligomerization inhibitors that can be used to prevent ?-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a ?-arrestin oligomerization inhibitor disclosed herein.

Abstract: In one example, a battery includes a negative terminal, a positive terminal, an electrolyte contained between the negative terminal and the positive terminal, and a hydrogel layer positioned between and physically separating the negative terminal and the positive terminal.

Abstract: In one example, a battery includes a negative terminal, a positive terminal, an electrolyte contained between the negative terminal and the positive terminal, and a hydrogel layer positioned between and physically separating the negative terminal and the positive terminal.

Abstract: In one example, a battery includes a negative terminal, a positive terminal, an electrolyte contained between the negative terminal and the positive terminal, and a hydrogel layer positioned between and physically separating the negative terminal and the positive terminal.

Abstract: A tire inflation system having a rotary coupling. The rotary coupling may have a mounting member and a rotating member. The rotating member may be rotatably coupled to the mounting member and may have a rotating member passage that may fluidly connect a first conduit to a second conduit that may be fluidly connected to the tire.

Abstract: In one example, a battery includes a negative terminal, a positive terminal, an electrolyte contained between the negative terminal and the positive terminal, and a hydrogel layer positioned between and physically separating the negative terminal and the positive terminal.

Abstract: A tire inflation system having a rotary coupling. The rotary coupling may have a mounting member and a rotating member. The rotating member may be rotatably coupled to the mounting member and may have a rotating member passage that may fluidly connect a first conduit to a second conduit that may be fluidly connected to the tire.

Abstract: A tire inflation system having a rotary coupling. The rotary coupling may have a mounting member and a rotating member. The rotating member may be rotatably coupled to the mounting member and may have a rotating member passage that may fluidly connect a first conduit to a second conduit that may be fluidly connected to the tire.

Abstract: A tire inflation system having a first conduit and a flange. The first conduit may supply a pressurized gas for inflating a tire. The flange may be coupled to an axle flange. The flange may have a passage that routes the pressurized gas through the flange.

Abstract: A tire inflation system for a vehicle. The tire inflation system may include a gas supply subsystem that may supply pressurized gas to a tire via first conduit that may be connected to an axle shaft.

Abstract: A tire inflation system having a rotary coupling. The rotary coupling may have a mounting member and a rotating member. The rotating member may be rotatably coupled to the mounting member and may have a rotating member passage that may fluidly connect a first conduit to a second conduit that may be fluidly connected to the tire.

Abstract: A tire inflation system for a vehicle. The tire inflation system may include a gas supply subsystem that may supply pressurized gas to a tire via first conduit that may be connected to an axle shaft.

Abstract: A tire inflation system having a first conduit and a flange. The first conduit may supply a pressurized gas for inflating a tire. The flange may be coupled to an axle flange. The flange may have a passage that routes the pressurized gas through the flange.