Abstract: This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.

Abstract: This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.

Abstract: This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.

Abstract: Provided herein are methods of treating immune-related disorders comprising administering to a patient suffering from the disorder a therapeutically effective amount of a LMP2-selective inhibitor and a therapeutically effective amount of a LMP7-selective inhibitor. Also provided herein are compositions comprising a LMP2-selective inhibitor and a LMP7-selective inhibitor.

Abstract: A childs educational toy including a base structure. The base has a controller and a speaker located therein. The top surface of the base has a plurality of depressions located thereon. The depressions have a corresponding button located therein. Further, the buttons each correspond to a number and a color. When a button is depressed the speaker will play a sound. Each sound is the color and number associated with the button pressed.

Abstract: Anchoring apparatus for a bed cover, comprising a base member (10) and a holding member (12, 120), wherein said base member (10) is configured to be affixed to a bed at a lower edge of a mattress (16) and includes a first portion (18) of a clip member, and said holding member (12, 120) comprises a second part of said clip member for enabling said base member (10) and said holding member (12, 120) to be releasably connected together, in use, said holding member further comprising a clamp member for releasably clamping a portion of said bed cover therein.

Abstract: This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.

Abstract: A lighting fixture includes a solid-state lighting source, such as an LED light source. A control module of the lighting fixture uses temperature sensing circuitry to determine a relative ambient temperature. When the ambient temperature is above a defined ambient temperature threshold, a drive signal is provided to the solid-state light source at a target drive level that corresponds to a normal light output level. When the ambient temperature is below the ambient temperature threshold, the drive signal is provided to the solid-state light source at a reduced drive level, which is lower than the target drive level.

Abstract: Anchoring apparatus for a bed cover, comprising a base member (10) and a holding member (12, 120), wherein said base member (10) is configured to be affixed to a bed at a lower edge of a mattress (16) and includes a first portion (18) of a clip member, and said holding member (12, 120) comprises a second part of said clip member for enabling said base member (10) and said holding member (12, 120) to be releasably connected together, in use, said holding member further comprising a clamp member for releasably clamping a portion of said bed cover therein.

Abstract: A flow measuring device for monitoring and measuring the flow of gaseous material, specifically high temperature gas using a low pressure drop measurement system, is provided. The device is adapted to fit within the pipeline of a flow system and may be installed wherever flow measurement is needed. In one embodiment, the device comprises a housing, multiple averaging pitot tubes to determine the total velocity and static pressure measurements, a differential pressure gauge to display the pressure, and a valve or valves to cut off flow as needed. Additionally, the present invention utilizes a means for cooling the temperature of the gas, thus negating the need for very expensive gauges capable of operating under very high temperatures. Overall, the flow measuring device herein provides a more efficient and cost-effective product and method to measure the flow of a liquid or gas, specifically a high temperature gas.

Abstract: A lighting fixture includes a solid-state lighting source, such as an LED light source. A control module of the lighting fixture uses temperature sensing circuitry to determine a relative ambient temperature. When the ambient temperature is above a defined ambient temperature threshold, a drive signal is provided to the solid-state light source at a target drive level that corresponds to a normal light output level. When the ambient temperature is below the ambient temperature threshold, the drive signal is provided to the solid-state light source at a reduced drive level, which is lower than the target drive level.

Abstract: This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.

Abstract: A fault-tolerant virtualized computer system comprises a primary host executing a primary virtual machine (VM) and a backup host executing a backup VM. In one embodiment, each VM includes a virtual disk mapped to a shared disk image on physical disk accessible to both hosts. A virtual disk IO request is received by virtualization software executing on the backup host from a backup VM. When the virtual disk IO request is a read request, the virtual disk IO request is mapped to a physical read IO request of a virtual disk image stored on a physical disk, the physical read IO request is issued to the physical disk. However, when the virtual disk IO request is a write request, it is assumed to be completed without mapping the virtual disk IO request or issuing a mapped physical IO request to the physical disk.

Abstract: A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.

Abstract: Fluid monitoring methods, systems and apparatus are disclosed, including a portable subassembly that is in electrical communication with a sensor in contact with the fluid being monitred. Preferred embodiments for the sensor include one or more flexural resonator sensing elements. In preferred embodiments the sensor subassembly is ported to multiple fluidic systems to monitor the fluid properties in an effecient manner.

Abstract: A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.

Abstract: Systems, methods and apparatus for designing a process to be performed at regions of an experiment library, the process involving the application of components at the library regions. Components are associated with regions of the experiment library. Each of the components represents a material or process parameter to be applied at the regions. A plurality of experiment stages are defined, each having one or more associated event types that are selected from predetermined event types and define a start condition for the corresponding stage. For each of the library regions, the components are associated with one or more of the experiment stages. A plurality of component profiles are generated, which represent processes to be performed at the various regions, and which describe the application over time of one or more of the components associated with a corresponding region or regions according to the associated experiment stages.

Abstract: A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.

Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine including a passage for containing a fluid; placing a sensor including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. A preferred sensor includes a tuning fork resonator.

Abstract: Fluid monitoring methods, systems and apparatus are disclosed. Preferred embodiments comprise one or more flexural resonator sensing elements. In preferred embodiments a sensor or a sensor subassembly is ported to multiple fluidic systems.