Abstract: A system for optimizing optics is provided. The system is configured to calibrate a position of a reference arm of an interferometric imaging system such that an image of a sample is visible when the sample is positioned at a working distance of an objective lens to provide an initial calibrated position. An image is obtained using the initial calibrated position. Image quality of the obtained image is assessed to determine if the obtained image is a valid image. A path length of the reference arm is adjusted if it is determined that the obtained image is not a valid image. A difference between the calibrated position of the reference arm and the adjusted position of the reference arm is calculated. System elements are adjusted based on the calculated difference such that the sample is visible when the sample is positioned at the working distance at the adjusted position.

Abstract: The invention relates to a processing system for use with optical coherence tomography imaging means for imaging a subject, the processing system being configured to repeatedly perform an image processing process (300), comprising the following steps: receiving (312) a scan data set from the subject (190) being acquired by means of optical coherence tomography, performing (314) data processing on the scan data set, including applying (316) dispersion correction based on a current set (370) of dispersion coefficients, and providing (318) a dispersion corrected image data set of the subject for an image of the subject to be displayed; and the processing system further being configured to repeatedly perform a dispersion coefficient adapting process (340), at least in part, in parallel to the image processing process (300), comprising the following steps: receiving (342) a scan data set from the subject being acquired by means of optical coherence tomography, adapting (344) dispersion coefficients by means of an

Abstract: The invention relates to a control system (130) for an imaging system (100) for real-time imaging of a subject (190), using optical coherence tomography and video imaging, the control system (130) being configured to: control the imaging system (100) to determine, from a video image (152) of the subject (190), a position and/or an orientation (152) of a tissue of interest (192) in the subject (190), control the imaging system (100) to perform a scan of the subject (190) by means of optical coherence tomography, wherein a position and/or an orientation (144) of the scan is determined based on the position and/or orientation (154) of the tissue of interest (192) in the video image (152), and provide an optical coherence tomography image (142) of the subject (190), including the tissue of interest (192), based on the scan, to an imaging system (100) and a corresponding method.

Abstract: The invention relates to a control system for an optical coherence tomography imaging system to be used with a microscopy system for viewing and/or imaging a subject (190, 192), the microscopy system comprising an objective (164) and a viewing lens system (170) including a relay lens (172), wherein the viewing lens system (170) is arranged at a subject’s side of the objective (164), the control system being configured to perform the following steps: controlling the optical coherence tomography imaging system to perform at least one radial scan of a surface (176) of the relay lens (172), determining, from data of the at least one radial scan at least one curve corresponding to a shape of the surface (176) of the relay lens (172), determining (520), from the at least one curve a lateral offset (178) between a center of the relay lens (172) and an origin of the optical coherence tomography imaging system, and adjusting the origin of the optical coherence tomography imaging system taking into account to the later

Abstract: A system for optimizing optics is provided. The system is configured to calibrate a position of a reference arm of an interferometric imaging system such that an image of a sample is visible when the sample is positioned at a working distance of an objective lens to provide an initial calibrated position. An image is obtained using the initial calibrated position. Image quality of the obtained image is assessed to determine if the obtained image is a valid image. A path length of the reference arm is adjusted if it is determined that the obtained image is not a valid image. A difference between the calibrated position of the reference arm and the adjusted position of the reference arm is calculated. System elements are adjusted based on the calculated difference such that the ample is visible when the sample is positioned at the working distance at the adjusted position.

Abstract: An apparatus for authenticating a user to gain access or entry. A correct final time interval count is associated with execution of a secure system act; it is revealed to or known by the user prior to ending the secure system act. A counter determines a final time interval count representing a number of time intervals from the beginning to the end of the secure system act. A validation unit validates the user as a valid user if the secure system act matches a correct secure system act and the final time interval count matches a correct final time interval count. If both determinations are affirmative the validation unit produces an authentication signal. In turn a control unit generates a control signal that permits access or entry to the user.

Abstract: An apparatus for authenticating a user to gain access or entry. A correct final time interval count is associated with execution of a secure system act; it is revealed to or known by the user prior to ending the secure system act. A counter determines a final time interval count representing a number of time intervals from the beginning to the end of the secure system act. A validation unit validates the user as a valid user if the secure system act matches a correct secure system act and the final time interval count matches a correct final time interval count. If both determinations are affirmative the validation unit produces an authentication signal. In turn a control unit generates a control signal that permits access or entry to the user.

Abstract: An apparatus for authenticating a user to gain access or entry. A correct final time interval count is associated with execution of a secure system act; it is revealed to or known by the user prior to ending the secure system act. A counter determines a final time interval count representing a number of time intervals from the beginning to the end of the secure system act. A validation unit validates the user as a valid user if the secure system act matches a correct secure system act and the final time interval count matches a correct final time interval count. If both determinations are affirmative the validation unit produces an authentication signal. In turn a control unit generates a control signal that permits access or entry to the user.

Abstract: An apparatus for authenticating a user to gain access or entry. A correct final time interval count is associated with execution of a secure system act; it is revealed to or known by the user prior to ending the secure system act. A counter determines a final time interval count representing a number of time intervals from the beginning to the end of the secure system act. A validation unit validates the user as a valid user if the secure system act matches a correct secure system act and the final time interval count matches a correct final time interval count. If both determinations are affirmative the validation unit produces an authentication signal. In turn a control unit generates a control signal that permits access or entry to the user.

Abstract: A method for gaining access or entry to a system. The method comprises (a) beginning a secure system act by a user; (b) beginning counting of time intervals concurrent with execution of step (a); (c) ending the secure system act by the user; (d) capturing a final time interval count concurrent with execution of step (c); (e) determining whether the secure system act matches a correct secure system act; (d) determining whether the final time interval count matches a correct final time interval count; and (e) granting the user access or entry to the system responsive affirmative results of step (d).

Abstract: A method for gaining access or entry to a system. The method comprises (a) beginning a secure system act by a user; (b) beginning counting of time intervals concurrent with execution of step (a); (c) ending the secure system act by the user; (d) capturing a final time interval count concurrent with execution of step (c); (e) determining whether the secure system act matches a correct secure system act; (d) determining whether the final time interval count matches a correct final time interval count; and (e) granting the user access or entry to the system responsive affirmative results of step (d).

Abstract: In one aspect the present invention provides methods for treating cancer in a mammal, including the step of administering to a mammal suffering from a cancer an amount of ebselen that is sufficient to inhibit the growth of the cancer. In another aspect, the present invention provides methods for enhancing the chemotherapeutic effect of a platinum-containing chemotherapeutic agent administered to a mammal suffering from cancer.

Abstract: In one aspect, the present invention provides chemoprotectant compositions that each comprise at least two of the chemoprotectants disclosed herein. The chemoprotectant compositions of the invention are useful, for example, for ameliorating at least one adverse effect of chemotherapy. In another aspect, the present invention provides methods of ameliorating at least one adverse effect of chemotherapy, the methods each comprising the step of administering to a subject undergoing chemotherapy an amount of a chemoprotectant composition that is effective to ameliorate at least one adverse effect of the chemotherapy.

Abstract: Specific BRCA1 mutations, PCR primers and hybridization probes are used in nucleic acid-based methods for diagnostic of inheritable breast cancer susceptibility. Additionally, binding agents, such as antibodies, specific for peptides encoded by the subject BRCA1 mutants are used to identify expression products of diagnostic mutations/rare alleles in patient derived fluid or tissue samples. Compositions with high binding affinity for transcription or translation products of the disclosed BRCA1 mutations and alleles are used in therapeutic intervention. Such products include anti-sense nucleic acids, peptides encoded by the subject nucleic acids, and binding agents such as antibodies, specific for such peptides.

Abstract: Specific BRCA1 mutations, PCR primers and hybridization probes are used in nucleic acid-based methods for diagnostic of inheritable breast cancer susceptibility. Additionally, binding agents, such as antibodies, specific for peptides encoded by the subject BRCA1 mutants are used to identify expression products of diagnostic mutations/rare alleles in patient derived fluid or tissue samples. Compositions with high binding affinity for transcription or translation products of the disclosed BRCA1 mutations and alleles are used in therapeutic intervention. Such products include anti-sense nucleic acids, peptides encoded by the subject nucleic acids, and binding agents such as antibodies, specific for such peptides.

Abstract: Specific BRCA1 mutations, PCR primers and hybridization probes are used in nucleic acid-based methods for diagnostic of inheritable breast cancer susceptibility. Additionally, binding agents, such as antibodies, specific for peptides encoded by the subject BRCA1 mutants are used to identify expression products of diagnostic mutations/rare alleles in patient derived fluid or tissue samples. Compositions with high binding affinity for transcription or translation products of the disclosed BRCA1 mutations and alleles are used in therapeutic intervention. Such products include anti-sense nucleic acids, peptides encoded by the subject nucleic acids, and binding agents such as antibodies, specific for such peptides.