Patents by Inventor Eric M. Tam

Eric M. Tam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-TNFR2 antibodies and uses thereof
    Patent number: 12435151
    Abstract: Disclosed herein are anti-TNFR2 antibodies, therapeutic compositions comprising the anti-TNFR2 antibodies, and methods of using such antibodies and compositions in the treatment of cancer and autoimmune diseases.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: October 7, 2025
    Assignee: Merrimack Pharmaceuticals, Inc.
    Inventors: Yu Zhou, James D. Marks, Marco Muda, James Frank Sampson, Eric M. Tam, Ross Bane Fulton
  • BISPECIFIC ANTIBODY FUSION MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20250197496
    Abstract: Described herein are compositions and methods for the efficient production of a heteromultimeric antibodies, such as a bispecific antibodies. The compositions and methods improve assembly of the heteromultimeric antibodies at higher yield and efficiency than conventional methods. Antibodies are optionally fused with a cytokine or costimulatory peptide or portions thereof. Also described herein are monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecific antibodies thereof that specifically bind CD3. Described herein are methods of making and using the anti-CD3 antibodies and antigen binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.
    Type: Application
    Filed: March 20, 2023
    Publication date: June 19, 2025
    Applicant: Evolvelmmune Therapeutics, Inc.
    Inventors: Mohosin Sarkar, Sonali Dhindwal, Jeremy S. Myers, Eric M. Tam, Guixian Jin, Shu Shien Chin, Parvez Rashid, Hayretin Rafet Yumerefendi
  • ANTI-TNFR2 ANTIBODIES AND USES THEREOF
    Publication number: 20220281990
    Abstract: Disclosed herein are anti-TNFR2 antibodies, therapeutic compositions comprising the anti-TNFR2 antibodies, and methods of using such antibodies and compositions in the treatment of cancer and autoimmune diseases.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 8, 2022
    Inventors: Yu ZHOU, James D. MARKS, Marco MUDA, James Frank SAMPSON, Eric M. TAM, Ross Bane FULTON
  • ANTI-TNFR2 ANTIBODIES AND USES THEREOF
    Publication number: 20210371537
    Abstract: Anti-TNFR2 antibodies which bind to particular human TNFR2 epitopes, therapeutic compositions comprising the anti-TNFR2 antibodies, and methods of using such antibodies and compositions in the treatment of cancer are disclosed.
    Type: Application
    Filed: September 18, 2019
    Publication date: December 2, 2021
    Inventors: Eric M. TAM, Marco MUDA, Klaus Andreas RAUE, Vinodh B. KURELLA, Daryl Clark DRUMMOND, Ross Bane FULTON, Fabien DEPIS, Anne-Sophie DUGAST, Jian TANG, Sandeep KUMAR
  • METHODS FOR SELECTING AND TREATING PATIENTS WITH A TRAIL-BASED THERAPEUTIC OR DEATH RECEPTOR AGONIST
    Publication number: 20190185541
    Abstract: Provided herein are methods of identifying cancer patients (e.g., colorectal cancer cancers) who will benefit from treatment with a TRAIL-based therapeutic or death receptor agonist based on their levels of DR4 and cIAP1. Also provided are methods of treating a patient diagnosed with cancer (e.g., colorectal cancer) based on their levels of DR4 and cIAP1.
    Type: Application
    Filed: June 13, 2017
    Publication date: June 20, 2019
    Inventors: Tamara DAKE, Sara GHASSEMIFAR, Yasmin HASHAMBHOY-RAMSAY, Diana Hung-yi Chai MARCANTONIO, Eric M. TAM, Haluk YUZUGULLU
  • ENGINEERED TRAIL FOR CANCER THERAPY
    Publication number: 20190077870
    Abstract: Engineered single chain trail molecules are provided, as are particular mutations and combinations of mutations that improve the stability and manufacturability of such molecules. These molecules are provided for use as anti-cancer therapeutics.
    Type: Application
    Filed: March 16, 2017
    Publication date: March 14, 2019
    Inventors: Diana Hung-yi Chai MARCANTONIO, Stephen L. SAZINSKY, Birgit M. SCHOEBERL, Eric M. TAM
  • CELL SURFACE DISPLAY USING PDZ DOMAINS
    Publication number: 20140038842
    Abstract: Novel materials and methods useful for displaying polypeptides on the surface of a cell are provided, including cell surface proteins fused to a PDZ domain peptide and antibodies fused to PDZ-binding peptides.
    Type: Application
    Filed: December 28, 2011
    Publication date: February 6, 2014
    Applicant: XOMA TECHNOLOGY
    Inventors: Eric M. Tam, Isaac J. Rondon, Chao B. Huang, Violet Votin