Abstract: Described herein are methods useful for detecting and diagnosing pathogen infection using PCR and sequencing.

Abstract: Embodiments herein relate to a system and method for retaining an insulated glass subassembly including a laminated layer of glass within a frame of a fenestration unit providing protection against wind borne debris. A fenestration unit can include a frame member defining a channel with a lower end and an attachment surface thereon along with a glass subassembly including a proximal end received and seated within the channel and an outside facing surface of the exterior pane proximate the lower end of the channel. A retention member can engage the interior laminate pane, and a glazing material can be on the attachment surface at the lower end of the channel. The outside facing surface of the glass subassembly can be attached to the channel of the frame member with the glazing material. In various embodiments, methods of making a retention member are included herein. Other embodiments are also included herein.

Abstract: Embodiments herein relate to methods for attachment of a retention member to an insulating glazing unit, resulting structures, and systems for the accomplishing the same. In some embodiments, a method of attaching a retention member to an insulating glazing unit can include placing a spacer unit between a first pane of glass and a second pane of glass to form the insulating glazing unit and applying an adhesive composition to at least one of a perimeter of the insulating glazing unit and the retention member. The method can further include mounting the retention member onto perimeter edges of at least one of the first pane and the second pane. Other embodiments are also included herein.

Abstract: Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma.

Abstract: The invention relates to RNA molecules encoding an E. coli fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the prevention of E. coli infection, including urinary tract infection.

Abstract: Provided herein are anti-CD21 antibodies or antigen binding fragments thereof and their use in the treatment of autoimmune diseases or disorders.

Abstract: A Pressurized Solution Extraction System and Method is disclosed herein. The pressurized solution extraction system comprises a cylinder and a piston, a locking mount connected to the end of the cylinder, a solute container having a plurality of holes and an interior diameter matching the that of the cylinder and in pressure contact to the end of the cylinder by the locking mount to create a chamber capable of holding a solute/solvent mix, a pressure sensor connected to the assembly and capable of taking pressure measurements of the solute/solvent mix, an actuator connected to the extraction chamber assembly, held in axial alignment by a frame, controlled by an actuator controller unit and a microcontroller in electronic communication with the pressure sensor, with the piston operating in a linear direction through the cylinder to force the solute/solvent mix through the solute container as directed by the microcontroller.

Abstract: Described herein are methods useful for detecting and diagnosing pathogen infection using PCR and sequencing.

Abstract: A PPL monitoring assembly for a hazardous environment is provided. The PPL monitoring assembly includes one or more sensors embedded in a wearable item, the one or more sensors including at least one of a temperature sensor or an accelerometer configured to measure a parameter of at least one of a wearer of the wearable item or the hazardous environment. The PPL monitoring assembly further includes an alert device configured to provide an alert, and a monitoring computing device in communication with the one or more sensors and the alert device, the monitoring computing device including at least one processor in communication with at least one memory device.

Abstract: A cooling system, for circulating air through an electrical system for a work machine, includes an electrical cabinet, a chassis of the wok machine, and a blower fluidly connected to the electrical cabinet and the chassis. The electrical cabinet defines an interior volume for accommodating a plurality of electrical components of the electrical system. The chassis defines a closed-loop passageway configured to receive air from the interior volume of the electrical cabinet. The blower circulates the air through the interior volume of the electrical cabinet and the closed-loop passageway of the chassis.

Abstract: The subject disclosure relates to systems, devices, and methods for executing operations related to procurement of individualized medicine therapies. Also disclosed are embodiments systems, methods, and devices for accessing a wide range of individualized medicine platform modules. Furthermore, disclosed herein are individualized medicine platform systems, methods and devices communicatively coupled to blockchain computing systems comprising several nodes. The disclosed systems, methods, and devices also generate chain of custody and chain of identity event data.

Abstract: A wood burning grill includes a cabinet that defines a coal support platform for supporting burning wood during a grilling process. A grate is positioned above the coal support platform and a grate positioning assembly mechanically couples the grate to the cabinet. The grate positioning assembly includes two four-bar linkage systems positioned on opposite sides of the grate for suspending the grate in cantilevered manner from the cabinet. Each four-bar linkage system includes a drive arm that is mechanically coupled to the drive gear and a support arm that maintains the grate in a substantially horizontal orientation while moving between the raised position and the lowered position. A hand wheel is rotatably mounted to the cabinet and is coupled to the drive gear through a rotating shaft and a worm gear such that rotating the hand wheel moves the grate between the raised position and the lowered position.

Abstract: The present invention provides for CD80-Fc fusion proteins that have therapeutic and diagnostic use, and methods for making thereof. The present invention further relates to variant CD80 polypeptides. The present invention also provides for CD80-Fc fusion proteins for use in the treatment of cancer.

Abstract: A storage system is provided that includes a stadium shaped bin having a bottom and an outer wall adjacent and extending from an outer edge of the bottom. The bottom and the outer wall defining an inner storage area. The bin having a plurality of legs located on a lower side of the bottom of the bin. The storage system further includes a lid having a raised top-hat portion about an upper surface and a skirt about an outer edge of the lid. The lid sized such that the skirt extends over the outer wall of the bin when the lid is placed on the bin, wherein the legs of the bin and raised top-hat portion of the lid are sized so that the legs nest about the raised top-hat portion of the lid when the bin is placed on the lid.

Abstract: A storage system is provided that includes a top, a bottom, a front, a back, a left side wall, and a right side wall. A storage area is defined by the top, bottom, left and right side walls. A plurality of full shelves are located within the storage area and extend between the left and right side walls. A plurality of partial shelves are located within the storage area, some of the partial shelves extend from the left side wall and some of the partial shelves extend from the right side wall. Removable handles are located on the left and right side walls. A skirt extends around at least a portion of a lower side of the bottom.

Abstract: A packaging assembly for a home appliance includes a base frame including a first plank and a second plank provided parallel to the first plank, and a pair of spring clips attached to the base frame. The pair of spring clips includes a right spring clip attached to a top surface of the first plank, and a left spring clip attached to a top surface of the second plank, wherein an axial extension direction of the right spring clip is parallel to an axial extension direction of the left spring clip, and wherein the pair of springs are configured to selectively accept a base rail of the home appliance therein.

Abstract: A scrubbing solution for removing contaminants, including particularly hydrogen sulfide, from a fluid. The scrubbing solution includes at least one scrubbing reagent which has a primary or secondary amine and an acid, which may be phosphoric acid. The fluid being scrubbed is passed through the scrubbing solution. The contaminants react with the scrubbing reagent securing them in the scrubbing solution. The fluid being scrubbed and the scrubbing solution are then separated. The scrubbing solution is heated and, if the scrubbing solution is under pressure, the pressure is reduced. The acid facilitates thorough removal of the contaminants, and especially the hydrogen sulfide, from the scrubbing solution. The scrubbing solution is then ready for reuse. Because the scrubbing solution is rendered substantially free of hydrogen sulfides, it can absorb other sulfide contaminants that might not otherwise be absorbed.

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: The subject disclosure relates to systems, devices, and methods for executing operations related to procurement of individualized medicine therapies. Also disclosed are embodiments systems, methods, and devices for accessing a wide range of individualized medicine platform modules. Furthermore, disclosed herein are individualized medicine platform systems, methods and devices communicatively coupled to blockchain computing systems comprising several nodes. The disclosed systems, methods, and devices also generate chain of custody and chain of identity event data.