Abstract: An assembly (10) for installation in a subsurface ground enclosure has an electronic transmitter, an antenna and other circuitry that are encapsulated against moisture conditions. The assembly (10) comprises a circuit board (31) supporting radio frequency transmitter circuitry, the circuit board (31) having at least two orthogonal edges (31b, 31c), an antenna (14, 15) having two 90-degree bent portions extending from orthogonal edges (31b, 31c) of the circuit board (31), a housing bottom portion (11) with an internal barrier (18) separating an L-shaped antenna compartment (13) adjacent two sides of the circuit board (31) from a battery compartment (16) underneath the circuit board (31), sealing material for encapsulating the circuit board (31) and the batteries (17) in the battery compartment (16), and a cover (20) that protects the antenna compartment (13) from entry of the sealing material.

Abstract: A water meter (10) and a flow control valve (30) are housed in a common pressure vessel (16), in which the flow control valve (30) restricts flow through a metering chamber (18) to less than the normal flow, while still permitting a flow sufficient for basic human needs, rather than completely interrupting supply of the utility, and in which the flow control valve (30) is controlled electrically through a control valve (40) in an energy efficient manner so as to utilize power from a self-contained power source (27) in another device (25) at the customer site (50).

Abstract: The present invention relates to novel biomarker for breast cancer, namely LSD1 and its application in inter alia the diagnosis of breast cancer. Furthermore, the present invention discloses a method of determining the LSD1 protein amount and the effect of LSD1 inhibitors on cancer cells selected from breast cancer, lung carcinoma and sarcoma.

Abstract: The present invention relates to a non-human transgenic animal whose genome comprises a stably integrated transgenic nucleotide sequence encoding Lysine-specific Demethylase 1 (LSD1) operably linked to a promoter. The invention further concerns methods for generating the non-human animal and its use as a cancer model.

Abstract: The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells.

Abstract: The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells.

Abstract: The present invention relates to an assay system for specific inhibitors of protein kinase C-related kinases (PRKs) relating to one or more of the reactions wherein said protein kinase C-related kinases are involved under physiological conditions. The invention also relates to a process for identifying specific inhibitors for protein kinase C-related kinases.

Abstract: An assembly (10) for installation in a subsurface ground enclosure has an electronic transmitter, an antenna and other circuitry that are encapsulated against moisture conditions. The assembly (10) comprises a circuit board (31) supporting radio frequency transmitter circuitry, the circuit board (31) having at least two orthogonal edges (31b, 31c), an antenna (14, 15) having two 90-degree bent portions extending from orthogonal edges (31b, 31c) of the circuit board (31), a housing bottom portion (11) with an internal barrier (18) separating an L-shaped antenna compartment (13) adjacent two sides of the circuit board (31) from a battery compartment (16) underneath the circuit board (31), sealing material for encapsulating the circuit board (31) and the batteries (17) in the battery compartment (16), and a cover (20) that protects the antenna compartment (13) from entry of the sealing material.

Abstract: The invention relates to a multiple-specificity demethylase complex comprising a Jumonji C (JMJC) domain-containing enzyme, a process of its preparation and its use.

Abstract: A combined utility meter and meter register assembly (10) is disclosed in which a housing (11, 13, 31) for both a utility metering element and a meter register has no visual readout or display of metering data. Metering data is signaled through a data port (33) or an antenna (36) to external equipment. The meter register is provided by electronic circuitry (29a, 29b) that is placed in an upper cavity (27) in the housing part (13) that is then closed by a cover (31) or a body of sealing material. A label (32) can be placed over the closure informational purposes. An additional embodiment of the housing is also disclosed.

Abstract: The invention relates to the use of at least one amine oxidase inhibitor for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical compositions for controlling the androgen receptor-dependent gene expression, comprising an effective dose of at least one amine oxidase inhibitor suitable for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to assay systems allowing to test LSD1 inhibitors for their ability to inhibit LSD1 function.

Abstract: The present invention relates to an assay system for specific inhibitors of protein kinase C-related kinases (PRKs) relating to one or more of the reactions wherein said protein kinase C-related kinases are involved under physiological conditions. The invention also relates to a process for identifying specific inhibitors for protein kinase C-related kinases.

Abstract: A combined utility meter and meter register assembly (10) is disclosed in which a housing (11, 13, 31) for both a utility metering element and a meter register has no visual readout or display of metering data. Metering data is signaled through a data port (33) or an antenna (36) to external equipment. The meter register is provided by electronic circuitry (29a, 29b) that is placed in an upper cavity (27) in the housing part (13) that is then closed by a cover (31) or a body of sealing material. A label (32) can be placed over the closure informational purposes. An additional embodiment of the housing is also disclosed.

Abstract: A water meter housing assembly (10) comprises a cylindrical, plastic housing body (11), a non-cast housing bottom (13) of hydroformable or stamped brass, a single-piece strainer and sealing member (40) that is disposed in the housing bottom (13) and portions of non-cast hydroformable or stamped brass tubing (15) with spud ends (16, 17) for connection in a water supply line. The brass consists essentially of lead-free material. The assembly (10) is designed to provide a lower cost alternative to foundry cast meter housings. The assembly (10) also provides advantages in a method of vertical assembly that saves manufacturing cost.

Abstract: A water meter housing assembly (10) comprises a cylindrical, plastic housing body (11), a non-cast housing bottom (13) of hydroformable or stamped brass, a single-piece strainer and sealing member (40) that is disposed in the housing bottom (13) and portions of non-cast hydroformable or stamped brass tubing (15) with spud ends (16, 17) for connection in a water supply line. The brass consists essentially of lead-free material. The assembly (10) is designed to provide a lower cost alternative to foundry cast meter housings. The assembly (10) also provides advantages in a method of vertical assembly that saves manufacturing cost.

Abstract: The invention relates to dirt separator module comprising a dirt-separation housing having an inlet and an outlet opening and defining a cyclonic airflow separator, and a suction source fluidly connected with the dirt-separation housing. A separator plate and a cylindrical wall of the dirt-separation housing form a toroidal cyclonic airflow chamber in the dirt-separator for aiding in the separation of dirt from a suction airstream developed by the suction source. The separator plate has an outer diameter smaller than the inner diameter of the cylindrical wall of the dirt-separation housing, creating a gap between the outer edge of the separator plate and the inner wall of the dirt tank. A further embodiment includes dual cyclonic separators fluidly connected through a filter assembly. A further embodiment includes a cyclonic separator in the form of a tangential helical ramp.