Patents by Inventor Eric Mozdy

Eric Mozdy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080063569
    Abstract: A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.
    Type: Application
    Filed: September 11, 2007
    Publication date: March 13, 2008
    Inventors: Norman Fontaine, Prantik Mazumder, Mark Quesada, Eric Mozdy, Po Yuen
  • Publication number: 20070237447
    Abstract: An optical interrogation system and a GCW sensor are described herein that are used to determine whether a biological substance (e.g., cell, molecule, protein, drug) is located in a sensing region of the GCW sensor. The optical interrogation system includes a light source, a polarization modulator and a detection system. The light source outputs a polarized light beam and the polarization modulator modulates the polarized light beam and outputs a polarization-modulated light beam. The GCW sensor receives and converts the polarization-modulated light beam into an amplitude modulated light beam that is directed towards the detection system. The detection system receives the amplitude modulated light beam and demodulates the received amplitude modulated light beam by responding to signals at a modulation frequency of the polarization-modulated light beam and ignoring noise affecting the signals outside the modulation frequency to detect a resonant condition (e.g., resonant angle, resonant wavelength).
    Type: Application
    Filed: September 26, 2005
    Publication date: October 11, 2007
    Inventor: Eric Mozdy
  • Publication number: 20060229818
    Abstract: The present invention includes several methods for modifying the current processes of manufacturing optical sensing microplates that use continuous waveguide films to reduce/eliminate crosstalk between the biosensors that are incorporated within wells. The methods include (1) physically deteriorating/removing the waveguide film between individual biosensors; (2) chemically depositing highly absorbing materials within the waveguide film between individual biosensors; (3) patterning disordered (scattering) regions between the diffraction gratings that define individual biosensors; (4) using a specific mask and depositing individual patches of waveguide film, where each patch defines at least one biosensor. Each of these methods and several other methods described herein prevent the propagation of light between individual sensing regions, thereby eliminating optical crosstalk between the biosensors. The present invention also includes the resulting microplate.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 12, 2006
    Inventors: Ye Fang, Ann Ferrie, Norman Fontaine, Anthony Frutos, Eric Mozdy, Chuan-Che Wang, Po Yuen
  • Publication number: 20060141486
    Abstract: The present invention relates to arrays comprising porous substrates for attachment of nucleic acids, polypeptides, membranes, or other biological or organic materials. In many embodiments, the arrays of the present invention have a flow-through configuration such that washing buffers or samples can access to the porous substrates from at least two sides of the arrays. The present invention also features arrays comprising UV-compatible porous substrates, arrays comprising three-dimensional membranes in sol-gels, and arrays comprising silica-based porous substrates prepared using a low-temperature fusion process.
    Type: Application
    Filed: December 29, 2004
    Publication date: June 29, 2006
    Inventors: Everett Coonan, Ye Fang, Ann Ferrie, Xiaodong Fu, Yulong Hong, Thomas Leslie, Xinghua Li, Beth Monahan, Eric Mozdy, Dirk Muller, Cameron Tanner, Patrick Tepesch, John Wight, Po Yuen
  • Publication number: 20060106557
    Abstract: A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.
    Type: Application
    Filed: November 18, 2004
    Publication date: May 18, 2006
    Inventors: Norman Fontaine, Prantik Mazumder, Mark Quesada, Eric Mozdy, Po Yuen
  • Publication number: 20060093254
    Abstract: An interrogation system and method are described herein which use a single-fiber launch/receive system for interrogating a biosensor (optical sensor) to detect the occurrence of a bio-chemical interaction (e.g., biological binding of ligands with analytes). In one embodiment, the single-fiber launch/receive system utilizes a multimode fiber to help interrogate the biosensor. In another embodiment, the single-fiber launch/receive system utilizes a downjacketed singlemode fiber to help interrogate the biosensor.
    Type: Application
    Filed: October 28, 2004
    Publication date: May 4, 2006
    Inventor: Eric Mozdy
  • Publication number: 20050236554
    Abstract: An optical interrogation system and method are described herein that can interrogate a two-dimensional (2D) array of optical sensors (e.g., grating coupled waveguide sensors) located in a 2D specimen plate (e.g., microplate). In one embodiment, the optical interrogation system has a launch system which directs an array of light beams towards the array of sensors in the two-dimensional specimen plate. The optical interrogation system also has a receive system that includes a Keplerian beam expander (used in reverse as a beam condenser) which receives an array of light beams output from the array of sensors and directs each received light beam to a unique region on the detection plane of a small area detector (e.g., CCD camera).
    Type: Application
    Filed: April 5, 2005
    Publication date: October 27, 2005
    Inventors: Norman Fontaine, Eric Mozdy, Po Yuen
  • Publication number: 20050099622
    Abstract: Optical interrogation systems and methods are described herein that are capable of measuring the angles (or changes in the angles) at which light reflects, transmits, scatters, or is emitted from an array of sensors or specimens that are distributed over a large area 2-dimensional array. In one embodiment of the present invention, the optical interrogation system has a far-field diffraction measurement configuration so it can simultaneously receive the light from sensors in all or a sub-section of a sensor array at a detector. In another embodiment of the present invention, the optical interrogation system incorporates an anamorphic optical receive system that enables parallel detection of angular responses from the sensors in the 2D array.
    Type: Application
    Filed: December 21, 2004
    Publication date: May 12, 2005
    Inventors: Stephen Caracci, Norman Fontaine, Eric Mozdy, Po Yuen
  • Publication number: 20050070027
    Abstract: A method for using a double resonance effect within a grating-coupled waveguide (GCW) sensor, as generated from a light beam with a given span of wavelengths or angles, is provided. The method can be used for label-independent detection of biological and chemical agents, to interrogate biological-binding events or chemical reactions within a sensing region at increased sensitivity, and with decreased sensitivity to environmental perturbations. Also described is an optical interrogation system incorporating the method.
    Type: Application
    Filed: September 30, 2003
    Publication date: March 31, 2005
    Inventors: Jacques Gollier, Eric Mozdy, Garrett Piech
  • Publication number: 20050025421
    Abstract: A grating-coupled waveguide (GCW) and a method are described herein that can be used to detect the presence of a biological substance (e.g., cell, drug, chemical compound) in a sensing region of the GCW. The GCW includes a substrate, a diffraction grating and a waveguide film that has a higher index of refraction than the substrate which has an index of refraction ?1.5. The relatively low-index substrate effectively increases the sensitivity of the GCW by causing the waveguide mode to shift towards a biological substance located in a sensing region above the waveguide film, thereby increasing the field strength of the mode's evanescent tail in this region. In one embodiment, an array of the GCWs are incorporated within the wells of a microplate.
    Type: Application
    Filed: August 1, 2003
    Publication date: February 3, 2005
    Inventors: Stephen Caracci, Mircea Despa, Eric Mozdy, Mark Salik
  • Publication number: 20050018944
    Abstract: An optical interrogation system and a GCW sensor are described herein that are used to determine whether a biological substance (e.g., cell, molecule, protein, drug) is located in a sensing region of the GCW sensor. The optical interrogation system includes a light source, a polarization modulator and a detection system. The light source outputs a polarized light beam and the polarization modulator modulates the polarized light beam and outputs a polarization-modulated light beam. The GCW sensor receives and converts the polarization-modulated light beam into an amplitude modulated light beam that is directed towards the detection system. The detection system receives the amplitude modulated light beam and demodulates the received amplitude modulated light beam by responding to signals at a modulation frequency of the polarization-modulated light beam and ignoring noise affecting the signals outside the modulation frequency to detect a resonant condition (e.g., resonant angle, resonant wavelength).
    Type: Application
    Filed: July 25, 2003
    Publication date: January 27, 2005
    Inventor: Eric Mozdy