Abstract: Provided herein are systems, devices, assemblies, and methods for localization of one or more tags in a patient.

Abstract: A device and method is disclosed for creating a lesion in adventitia tissue of a renal artery and/or a region of tissue surrounding the adventitia tissue while protecting intima and media tissue of the renal artery from injury. A catheter carrying a microwave antenna is positioned within the renal artery. Cooling fluid is circulated around the microwave antenna in thermal contact with the intima of the renal artery. Power is supplied to the microwave antenna to cause microwave energy to be emitted omnidirectionally from the microwave antenna. The power supplied to the microwave antenna and the cooling fluid circulated around the microwave antenna are controlled to cause the adventitia tissue and/or the region of tissue surrounding the adventitia tissue to be heated to a temperature sufficient to cause thermal damage while the intima and media tissue are maintained at a temperature where thermal damage does not occur.

Abstract: A method of performing denervation with a cooled microwave denervation catheter assembly includes advancing a catheter body over a guide wire in a body lumen of a patient to a treatment location adjacent targeted nerves, with the guide wire being located in an interior lumen of the catheter body, inflating the balloon with cooling fluid to contact a wall of the body lumen of the patient, removing the guide wire from the interior lumen of the catheter body, and inserting a microwave antenna catheter into the interior lumen of the catheter body, so that denervation treatment may be performed by simultaneously circulating cooling fluid in the balloon and supplying power to the microwave antenna, to cause the targeted nerves to be heated to a temperature sufficient to cause thermal damage while the wall of the body lumen is maintained at a temperature where thermal damage does not occur.

Abstract: Provided herein are systems, devices, assemblies, and methods for localization of one or more tags in a patient.

Abstract: Provided herein are systems, devices, assemblies, and methods for localization of a tag in a tissue of a patient. For example, provided herein are systems, devices, and methods employing an implantable tag that emits sidebands at defined frequencies upon activation by a magnetic field generated by a remote activating device, and a plurality of witness stations configured to detect such sidebands. Also provided herein are herein are systems, devices, and methods employing a detection component that is attached to or integrated with a surgical device.

Abstract: A device and method is disclosed for creating a lesion in adventitia tissue of a renal artery and/or a region of tissue surrounding the adventitia tissue while protecting intima and media tissue of the renal artery from injury. A catheter carrying a microwave antenna is positioned within the renal artery. Cooling fluid is circulated around the microwave antenna in thermal contact with the intima of the renal artery. Power is supplied to the microwave antenna to cause microwave energy to be emitted omnidirectionally from the microwave antenna. The power supplied to the microwave antenna and the cooling fluid circulated around the microwave antenna are controlled to cause the adventitia tissue and/or the region of tissue surrounding the adventitia tissue to be heated to a temperature sufficient to cause thermal damage while the intima and media tissue are maintained at a temperature where thermal damage does not occur.

Abstract: Provided herein are systems, devices, assemblies, and methods for localization of a tag in a tissue of a patient. For example, provided herein are systems, devices, and methods employing an implantable tag that emits sidebands at defined frequencies upon activation by a magnetic field generated by a remote activating device, and a plurality of witness stations configured to detect such sidebands. Also provided herein are herein are systems, devices, and methods employing a detection component that is attached to or integrated with a surgical device.

Abstract: A method of performing denervation with a cooled microwave denervation catheter assembly includes advancing a catheter body over a guide wire in a body lumen of a patient to a treatment location adjacent targeted nerves, with the guide wire being located in an interior lumen of the catheter body, inflating the balloon with cooling fluid to contact a wall of the body lumen of the patient, removing the guide wire from the interior lumen of the catheter body, and inserting a microwave antenna catheter into the interior lumen of the catheter body, so that denervation treatment may be performed by simultaneously circulating cooling fluid in the balloon and supplying power to the microwave antenna, to cause the targeted nerves to be heated to a temperature sufficient to cause thermal damage while the wall of the body lumen is maintained at a temperature where thermal damage does not occur.

Abstract: Provided herein are systems, devices, assemblies, and methods for localization of one or more tags in a patient.

Abstract: Provided herein are systems, devices, assemblies, and methods for localization of a tag in a tissue of a patient. For example, provided herein are systems, devices, and methods employing an implantable tag that emits sidebands at defined frequencies upon activation by a magnetic field generated by a remote activating device, and a plurality of witness stations configured to detect such sidebands. Also provided herein are herein are systems, devices, and methods employing a detection component that is attached to or integrated with a surgical device.

Abstract: A device and method is disclosed for creating a lesion in adventitia tissue of a renal artery and/or a region of tissue surrounding the adventitia tissue while protecting intima and media tissue of the renal artery from injury. A catheter carrying a microwave antenna is positioned within the renal artery. Cooling fluid is circulated around the microwave antenna in thermal contact with the intima of the renal artery. Power is supplied to the microwave antenna to cause microwave energy to be emitted omnidirectionally from the microwave antenna. The power supplied to the microwave antenna and the cooling fluid circulated around the microwave antenna are controlled to cause the adventitia tissue and/or the region of tissue surrounding the adventitia tissue to be heated to a temperature sufficient to cause thermal damage while the intima and media tissue are maintained at a temperature where thermal damage does not occur.

Abstract: A device and method is disclosed for creating a lesion in adventitia tissue of a renal artery and/or a region of tissue surrounding the adventitia tissue while protecting intima and media tissue of the renal artery from injury. A catheter carrying a microwave antenna is positioned within the renal artery. Cooling fluid is circulated around the microwave antenna in thermal contact with the intima of the renal artery. Power is supplied to the microwave antenna to cause microwave energy to be emitted omnidirectionally from the microwave antenna. The power supplied to the microwave antenna and the cooling fluid circulated around the microwave antenna are controlled to cause the adventitia tissue and/or the region of tissue surrounding the adventitia tissue to be heated to a temperature sufficient to cause thermal damage while the intima and media tissue are maintained at a temperature where thermal damage does not occur.

Abstract: A cooled microwave denervation catheter includes a catheter body having at least one fluid passage and an interior lumen therein, a balloon in communication with the at least one fluid passage to receive cooling fluid to inflate the balloon, and a microwave antenna catheter configured to be inserted into the interior lumen of the catheter body. The microwave antenna catheter has a distal end configured to engage a taper of the interior lumen, thereby positioning the microwave antenna in a desired location of the interior lumen.

Abstract: A catheter is disclosed for creating a lesion in nerve-containing tissue spaced from a body lumen while protecting tissue forming and adjacent to a wall of the body lumen from injury. The catheter includes a catheter body having at least one fluid passage therein, a balloon in communication with the at least one fluid passage to receive cooling fluid for inflating the balloon, a microwave antenna carried by the catheter that emits microwave energy omnidirectionally, thereby heating the tissue spaced from the body lumen to a temperature sufficient to cause thermal damage while the tissue forming and adjacent to the wall of the body lumen are maintained at a temperature where thermal damage does not occur, and a tip structure located at an end of the catheter body, configured to receive a guide wire extending through the at least one fluid passage in the catheter body.

Abstract: A device and method is disclosed for creating a lesion in adventitia tissue of a renal artery and/or a region of tissue surrounding the adventitia tissue while protecting intima and media tissue of the renal artery from injury. A catheter carrying a microwave antenna is positioned within the renal artery. Cooling fluid is circulated around the microwave antenna in thermal contact with the intima of the renal artery. Power is supplied to the microwave antenna to cause microwave energy to be emitted omnidirectionally from the microwave antenna. The power supplied to the microwave antenna and the cooling fluid circulated around the microwave antenna are controlled to cause the adventitia tissue and/or the region of tissue surrounding the adventitia tissue to be heated to a temperature sufficient to cause thermal damage while the intima and media tissue are maintained at a temperature where thermal damage does not occur.

Abstract: A pressure sensing device includes a body portion, a pressure transmitting port, and an electrical lead. The body portion includes transducing electronics within a housing that is shaped about a longitudinal axis. The housing has a coating thereon that promotes tissue growth to anchor the housing within a ventricular septum. The pressure transmitting port is located at a distal longitudinal end of the body portion such that a ventricle pressure being sensed is transmitted through the port and to the transducing electronics when the body portion is anchored in the ventricular septum. The electrical lead is connected to the transducing electronics and exits from a proximal longitudinal end of the body portion.

Abstract: A thermal therapy catheter for preferentially treating tissue adjacent to a body lumen includes a catheter shaft that is insertable into the body lumen. An energy-emitting element is carried by the catheter shaft, and is operable to radiate a generally symmetrical energy pattern. The catheter shaft includes a plurality of cooling lumens around the energy-emitting element, configured for circulation of a fluid therethrough. An attenuating element is located in at least one of the plurality of cooling lumens and is arranged to modify the generally symmetrical energy pattern radiated by the energy-emitting element to deliver an asymmetrical energy pattern to the tissue adjacent to the body lumen.

Abstract: A tissue ablation device includes a catheter shaft having an antenna lumen, an impedance-matched microwave antenna carried in the antenna lumen of the catheter shaft, at least one cooling lumen in the catheter shaft around the antenna lumen for circulation of cooling fluid, and a microwave generator operatively coupled to the antenna for energizing the antenna to create a lesion in the targeted tissue around the catheter shaft having a controlled location and size. In an exemplary embodiment, a tip is attached to an end of the catheter shaft for penetrating the tissue targeted for treatment. The device is effective for laparascopic or percutaneous procedures to treat tissues such as the kidney.

Abstract: A thermal therapy catheter includes a catheter shaft having an outer surface that is insertable into the body lumen. The catheter shaft carries an energy-emitting element. A multi-lobe balloon is positioned around the outer surface of the catheter shaft adjacent to the energy-emitting element, with opposing ends of the multi-lobe balloon being sealingly connected to the catheter shaft to form a chamber between the multi-lobe balloon and the outer surface of the catheter shaft. Fluid is circulated between the outer surface of the catheter shaft and the multi-lobe balloon in a defined fluid flow path to firmly contact the wall of the body lumen and thereby cool the body lumen tissue while thermally treating targeted tissue at a depth from the body lumen wall.

Abstract: A thermal therapy method includes inserting an applicator including an energy-emitting device into a body cavity such as a urethra adjacent a targeted tissue region such as a prostate, energizing the energy-emitting device, and circulating coolant between the energy-emitting device and a wall of the body cavity. The therapy is controlled by decreasing a temperature of the coolant and continually adjusting coolant temperature based on therapy parameters. The applicator, or selected tissue at a predetermined depth from the wall of the body cavity, is maintained at a temperature corresponding to a predetermined applicator temperature profile by adjusting a power level provided to the energy-emitting device.