Abstract: Disclosed are devices, systems, and methods of a wearable compression control system for actively controlling an applied pressure against an extremity to restrict blood flow along the extremity of a user performing an exercise or undergoing a therapy. In some embodiments, the system can include an inflatable band that extends circumferentially around the extremity. The inflatable band can include a bladder having an expandable inner volume for receiving fluid to cause the inflatable band to increase in thickness and increase an applied pressure against the extremity. The system can further include a controller that releasably couples to the inflatable band and includes a processor having a programmed pressure range. The processor can be configured to actively maintain the applied pressure within the programmed pressure range throughout the user performing the exercise or the user undergoing the therapy.