Abstract: Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Abstract: A mixer for a vehicle exhaust gas system includes a mixer housing defining an internal cavity and having a mixer inlet configured to receive exhaust gas and a mixer outlet to direct exhaust gas to downstream exhaust components. A flow device is configured to receive the exhaust gas from the mixer inlet and to facilitate mixing of the exhaust gas and a reductant introduced into the first flow device. The flow device comprises a Venturi body centered on a body center axis, and the Venturi body comprises a body inlet configured to receive the exhaust gas from the mixer inlet and a body outlet configured to provide the exhaust gas to the mixer outlet. The Venturi body also includes a support flange extending from the body outlet at an offset angle to an internal edge of the mixer housing. An upstream vane is positioned within the Venturi body proximate the body inlet and is coupled to an upstream vane hub that is centered on an upstream vane hub axis.

Abstract: An exhaust component includes a housing defining an internal cavity, at least one exhaust aftertreatment component positioned within the internal cavity, and a heat exchanger. The housing has an inlet configured to receive engine exhaust gases and an outlet configured to direct the engine exhaust gasses into a tailpipe. A reductant source is associated with the housing and produces ammonia to mix with engine exhaust gases entering the exhaust aftertreatment component. The heat exchanger is positioned within the internal cavity to reduce a temperature of the engine exhaust gases exiting the outlet.

Abstract: A vehicle exhaust component assembly includes a first exhaust component, a second exhaust component downstream of the first exhaust component, and an injection system configured to inject a reducing agent into engine exhaust gases upstream of the second exhaust component. A mixer connects an outlet of the first exhaust component to an inlet to the second exhaust component. The mixer includes an outer housing that is configured to direct a mixture of the reducing agent and the engine exhaust gases into the second exhaust component. The mixer also includes at least one insulation feature that is configured to reduce heat lost at the outer housing.

Abstract: A vehicle exhaust component assembly includes a first exhaust component, a second exhaust component downstream of the first exhaust component, and an injection system configured to inject a reducing agent into engine exhaust gases upstream of the second exhaust component. A mixer connects an outlet of the first exhaust component to an inlet to the second exhaust component. The mixer includes an outer housing that is configured to direct a mixture of the reducing agent and the engine exhaust gases into the second exhaust component. The mixer also includes at least one insulation feature that is configured to reduce heat lost at the outer housing.