Patents by Inventor Eric Nordman
Eric Nordman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10557167Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.Type: GrantFiled: March 2, 2017Date of Patent: February 11, 2020Assignee: QUANTUM BIOSYSTEMS INC.Inventors: Tomoji Kawai, Masateru Taniguchi, Takahito Ohshiro, Mark Oldham, Eric Nordman
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Publication number: 20190242846Abstract: Methods and systems are provided for creation of stable and consistent nanoelectrode pairs for detection of biomolecules, such as deoxyribonucleic acid.Type: ApplicationFiled: February 4, 2019Publication date: August 8, 2019Inventors: Masateru TANIGUCHI, Takahito Ohshiro, Makusu Tsutsui, Kazumichi Yokota, Toshiki Matsuoka, Mark Oldham, Eric Nordman
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Publication number: 20180023132Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.Type: ApplicationFiled: March 2, 2017Publication date: January 25, 2018Inventors: Tomoji Kawai, Masateru Taniguchi, Takahito Ohshiro, Mark Oldham, Eric Nordman
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Patent number: 9644236Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.Type: GrantFiled: March 4, 2016Date of Patent: May 9, 2017Assignee: QUANTUM BIOSYSTEMS INC.Inventors: Tomoji Kawai, Masateru Taniguchi, Takahito Ohshiro, Mark Oldham, Eric Nordman
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Publication number: 20160319342Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.Type: ApplicationFiled: March 4, 2016Publication date: November 3, 2016Inventors: Tomoji Kawai, Masateru Taniguchi, Takahito Ohshiro, Mark Oldham, Eric Nordman
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Publication number: 20160245790Abstract: The present disclosure provides methods and systems that can reduce the amount of sample necessary to detect or identify, or both detect and identify, a biomolecule, and increase the rate of denaturing of the biomolecule. A device for thermally denaturing a biomolecule may include: a substrate having low thermal conductivity; a heater disposed adjacent to the substrate; a temperature sensor disposed adjacent to the substrate; a semiconductor oxide film disposed adjacent to the substrate, a nanochannel formed in a region of the semiconductor oxide film, and a cover over the nanochannel.Type: ApplicationFiled: February 19, 2016Publication date: August 25, 2016Inventors: Tomoji Kawai, Masayuki Furuhashi, Masateru Kawaguchi, Mark Oldham, Eric Nordman
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Publication number: 20160245789Abstract: The present disclosure provides methods for forming a nano-gap electrode. In some cases, a nano-gap having a width adjusted by a film thickness of a sidewall may be formed between a first electrode-forming part and a second electrode-forming part using sidewall which has contact with first electrode-forming part as a mask. Surfaces of the first electrode-forming part, the sidewall and the second electrode-forming part may then be exposed. The sidewall may then be removed to form a nano-gap between the first electrode-forming part and the second electrode-forming part.Type: ApplicationFiled: February 19, 2016Publication date: August 25, 2016Inventors: Shuji Ikeda, Mark Oldham, Eric Nordman
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Patent number: 9285316Abstract: System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light. The system for analyzing samples comprising: a light source that provides a non-coherent excitation light; at least one housing, wherein the housing transports samples and propagates the non-coherent excitation light by total internal reflection; a coupling optical element configured to introduce the non-coherent excitation light into the at least one housing through a wall of the at least one housing; and at least one NA enhancing optical element to collect an emitted fluorescence, wherein the NA enhancing optical element is constructed of a first material and the housing is constructed of a second material, wherein the first material has a greater index of refraction than the second material.Type: GrantFiled: July 24, 2014Date of Patent: March 15, 2016Assignee: Applied Biosystems, LLCInventors: Richard Reel, Eric Nordman
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Publication number: 20160047747Abstract: A device including a transparent layer defining a surface exposed to a flow volume and to secure a target polynucleotide template and a detector structure secured to the transparent layer and including a plurality of detectors to detect a signal emitted during nucleotide incorporation along the target polynucleotide template.Type: ApplicationFiled: April 2, 2014Publication date: February 18, 2016Inventors: Michael M. LAFFERTY, Jonathan M. ROTHBERG, Keith G. FIFE, Mark OLDHAM, Eric NORDMAN
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Publication number: 20150048258Abstract: System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.Type: ApplicationFiled: July 24, 2014Publication date: February 19, 2015Inventors: Richard REEL, Eric NORDMAN
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Publication number: 20140326898Abstract: System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.Type: ApplicationFiled: March 31, 2014Publication date: November 6, 2014Applicant: Applied Biosystems, LLCInventors: Richard REEL, Eric NORDMAN
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Publication number: 20140192532Abstract: System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.Type: ApplicationFiled: December 16, 2013Publication date: July 10, 2014Applicant: Applied Biosystems, LLCInventors: Richard Reel, Eric Nordman
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Publication number: 20140091233Abstract: System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.Type: ApplicationFiled: September 20, 2013Publication date: April 3, 2014Applicant: Applied Biosystems, LLCInventors: Richard REEL, Eric Nordman
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Publication number: 20140045701Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.Type: ApplicationFiled: October 4, 2011Publication date: February 13, 2014Applicant: GENAPSYS INC.Inventors: Hesaam Esfandyarpour, Mark F. Oldham, Kosar Parazi, Eric Nordman
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Publication number: 20140009943Abstract: System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.Type: ApplicationFiled: May 16, 2013Publication date: January 9, 2014Applicant: Applied Biosystems, LLCInventors: Richard REEL, Eric NORDMAN
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Patent number: 8446588Abstract: System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.Type: GrantFiled: May 7, 2012Date of Patent: May 21, 2013Assignee: Applied Biosystems, LLCInventors: Richard Reel, Eric Nordman
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Publication number: 20130096013Abstract: The present invention provides for methods and systems for Electronic DNA sequencing, single molecule DNA sequencing, and combinations of the above, providing low cost and convenient sequencing.Type: ApplicationFiled: October 1, 2012Publication date: April 18, 2013Applicant: Genapsys, Inc.Inventors: Hesaam Esfandyarpour, Mark Oldham, Eric Nordman
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Patent number: 8384899Abstract: An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.Type: GrantFiled: April 9, 2012Date of Patent: February 26, 2013Assignee: Applied Biosystems, LLCInventors: Mark Oldham, Eric Nordman, Richard Reel, Janice Shigeura
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Patent number: 8384898Abstract: An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.Type: GrantFiled: April 9, 2012Date of Patent: February 26, 2013Assignee: Applied Biosystems, LLCInventors: Mark Oldham, Eric Nordman, Richard Reel, Janice Shigeura
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Patent number: 8169610Abstract: An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.Type: GrantFiled: June 6, 2011Date of Patent: May 1, 2012Assignee: Life Technologies CorporationInventors: Mark Oldham, Eric Nordman, Richard Reel, John Shigeura, Janice Shigeura, legal representative