Abstract: Methods for detecting the presence of atherosclerotic structures in order to diagnose or prevent atherosclerosis are provided herein. In particular, it has been found that methylene blue injected intravenously acts as an excellent indicator because the compound targets high-risk plaque, atheroma, macrophages, and other atherosclerotic structures formed within the endothelial walls of a vessel of a subject. Because the compound provides a unique binding profile with uptake only in plaque or atheroma, and not the normal or healthy vascular interstitial tissue, methylene blue maintains a good plaque-to-background ratio for imaging purposes. This enables healthcare providers to determine the status of atherosclerosis development in vivo within a patient with higher certainty and at lower costs. The disclosed methods allow for high-resolution mapping of plaque build-up, plaque pathobiology, and other atherosclerotic structures within a vessel of a subject by using methylene blue as an imaging agent.

Abstract: Methods for detecting the presence of atherosclerotic structures in order to diagnose or prevent atherosclerosis are provided herein. In particular, it has been found that methylene blue injected intravenously acts as an excellent indicator because the compound targets high-risk plaque, atheroma, macrophages, and other atherosclerotic structures formed within the endothelial walls of a vessel of a subject. Because the compound provides a unique binding profile with uptake only in plaque or atheroma, and not the normal or healthy vascular interstitial tissue, methylene blue maintains a good plaque-to-background ratio for imaging purposes. This enables healthcare providers to determine the status of atherosclerosis development in vivo within a patient with higher certainty and at lower costs. The disclosed methods allow for high-resolution mapping of plaque build-up, plaque pathobiology, and other atherosclerotic structures within a vessel of a subject by using methylene blue as an imaging agent.

Abstract: A ply wire sensor system is provided for a tire carcass ply in a green tire carcass having a toroidal shape, the tire carcass ply having a plurality of spaced apart ply wires extending across the toroidal shape. The sensor system includes a wire sensor mounted in close proximity with the tire carcass ply, the wire sensor detecting the presence of a proximal ply wire; and means for establishing relative movement between the wire sensor and the tire carcass whereby the plurality of spaced apart ply wires are sequentially placed into proximity with the wire sensor. The wire sensor generates sequential data indicative of at least one ply wire parameter of the plurality of spaced apart ply wires.

Abstract: A method for detecting ply wire anomalies in a tire carcass ply having a plurality of spaced apart ply wires extending across a tire carcass, the method comprising the steps: constructing a green tire carcass in a diametrically expanded toroidal configuration, the carcass comprising a pair of beads, the carcass ply extending from bead to bead, at least one crown layer covering the carcass ply and having a peripheral skirt region; and sidewalls covering the carcass ply and extending from the beads to the crown layer and having edge portions intersecting the crown layer; mounting a wire sensor apparatus proximal to the tire carcass ply, the wire sensor apparatus including a wire sensor for detecting the presence of a proximal ply wire; establishing relative movement between the wire sensor and the tire carcass whereby the plurality of spaced apart ply wires are sequentially placed into proximal relationship with the wire sensor; and generating sequential data from the wire sensor indicative of at least one ply