Patents by Inventor Eric P. Lodge

Eric P. Lodge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide analogs as irreversible interleukin-1beta protease inhibitors
    Publication number: 20040009923
    Abstract: Disclosed are compounds, compositions and methods for inhibiting interleukin-1&bgr; protease activity, the compounds having the formula (I).
    Type: Application
    Filed: January 16, 2003
    Publication date: January 15, 2004
    Inventors: Roland E. Dolle, Irennegbe K. Osifo, Stanley J. Schmidt, Denton W. Hoyer, Tina Morgan Ross, Prasad V. Chaturvedula, Catherine P. Prouty, Mohamed M.A. Awad, Joseph M. Salvino, James M. Rinker, Eric P. Lodge, Jasbir Singh, Mark A. Ator
  • Peptide analogs as irreversible interleukin-1&bgr; protease inhibitors
    Patent number: 6576614
    Abstract: Disclosed are compounds, compositions, and methods for inhibiting interleukin-1&bgr; protease activity, wherein the compounds are &agr;-substituted methyl ketones having formula (I) as set forth herein. These compounds are inhibitors of IL-1&bgr; converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: June 10, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Roland E. Dolle, Irennegbe K. Osifo, Stanley J. Schmidt, Denton W. Hoyer, Tina Morgan Ross, Prasad V. Chaturvedula, Catherine P. Prouty, Mohamed M. A. Awad, Joseph M. Salvino, James M. Rinker, Eric P. Lodge, Jasbir Singh, Mark A. Ator
  • Peptide analogs as irreversible interleukin-1.beta. protease inhibitors
    Patent number: 5985838
    Abstract: Disclosed are compounds, compositions and methods for inhi.beta.iting interleukin-1.beta. protease activity, the compounds .alpha.-substituted methyl ketones having the formula (I) set forth herein. These compounds are inhibitors of IL-1.beta. converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: November 16, 1999
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Roland E. Dolle, Irennegbe K. Osifo, Stanley J. Schmidt, Denton W. Hoyer, Tina Morgan Ross, Prasad V. Chaturvedula, Catherine P. Prouty, Mohamed M. A. Awad, Joseph M. Salvino, James M. Rinker, Eric P. Lodge, Jasbir Singh, Mark A. Ator
  • Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5596012
    Abstract: Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula ##STR1## wherein: L is --O--, --S--, --SO--or --SO.sub.2 --;m and n are each independently 0 or 1;R.sub.1 is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or substituted heterocyclyl or, when L is --O-- and n is 1, cycloheptatrienon-2-yl or, when L is --S-- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is --SO.sub.2 -- and n is 1, lower-alkyl or trifluoromethyl; R.sub.2 is hydrogen, lower-alkoxycarbonyl, phenyl or phenylthio; andR.sub.3 and R.sub.4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: January 21, 1997
    Assignee: Sterling winthrop Inc.
    Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Chakrapani Subramanyam, Lee H. Latimer, Eric P. Lodge
  • Use of saccharin derivatives as proteolytic enzyme inhibitors
    Patent number: 5371074
    Abstract: Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula 0010wherein:L is --O--, --S--, --SO-- or --SO.sub.2 --; m and n are each independently 0 or 1; R.sub.1 is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or substitued heterocyclyl or, when L is --O-- and n is 1, cycloheptatrienon-2-yl or, when L is --S-- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is --SO.sub.2 -- and n is 1, lower-alkyl or trifluoromethyl; R.sub.2 is hydrogen, lower-alkoxycarbonyl, phenyl or phenylthio; and R.sub.3 and R.sub.4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.
    Type: Grant
    Filed: May 24, 1993
    Date of Patent: December 6, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Chakrapani Subramanyam, Lee H. Latimer, Eric P. Lodge
  • Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5236917
    Abstract: Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula ##STR1## wherein: L is --O--, --S--, --SO-- or --SO.sub.2 --;m and n are each independently 0 or 1;R.sub.1 is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or substituted heterocyclyl or, when L is --O-- and n is 1, cycloheptatrienon-2-yl or, when L is --S-- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is --SO.sub.2 -- and n is 1, lower-alkyl or trifluoromethyl;R.sub.2 is hydrogen, lower-alkoxycarbonyl, phenyl or phenylthio; andR.sub.3 and R.sub.4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: August 17, 1993
    Assignee: Sterling Winthrop Inc.
    Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Chakrapani Subramanyam, Lee H. Latimer, Eric P. Lodge