Patents by Inventor Eric Pearlman

Eric Pearlman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fungal iron acquisition inhibitors and uses thereof
    Patent number: 11779634
    Abstract: A method of treating a fungal infection in a subject includes topically administering to the subject a therapeutically effective amount of a fungal iron acquisition inhibitor to treat fungal infection in the subject.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: October 10, 2023
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Eric Pearlman, Sixto M. Leal, Jr.
  • FUNGAL IRON ACQUISITION INHIBITORS AND USES THEREOF
    Publication number: 20220211820
    Abstract: A method of treating a fungal infection in a subject includes topically administering to the subject a therapeutically effective amount of a fungal iron acquisition inhibitor to treat fungal infection in the subject.
    Type: Application
    Filed: January 25, 2022
    Publication date: July 7, 2022
    Inventors: Eric Pearlman, Sixto M. Leal, JR.
  • Fungal iron acquisition inhibitors and uses thereof
    Patent number: 11229685
    Abstract: A method of treating a fungal infection in a subject includes topically administering to the subject a therapeutically effective amount of a fungal iron acquisition inhibitor to treat fungal infection in the subject.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: January 25, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Eric Pearlman, Sixto M. Leal, Jr.
  • Ceramide composition and method of use
    Patent number: 10869847
    Abstract: A method for treating and preventing diseases associated with neutrophil infiltration, particularly ocular diseases, is provided, which method comprises administering to a subject in need thereof an effective amount of ceramide or a derivative thereof. Also provided is a composition for treating diseases associated with neutrophil infiltration, the composition comprising ceramide or a derivative thereof.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: December 22, 2020
    Assignees: Case Western Reserve University, The Penn State Research Foundation
    Inventors: Eric Pearlman, Mark Kester
  • CERAMIDE COMPOSITION AND METHOD OF USE
    Publication number: 20190029978
    Abstract: A method for treating and preventing diseases associated with neutrophil infiltration, particularly ocular diseases, is provided, which method comprises administering to a subject in need thereof an effective amount of ceramide or a derivative thereof. Also provided is a composition for treating diseases associated with neutrophil infiltration, the composition comprising ceramide or a derivative thereof.
    Type: Application
    Filed: July 26, 2018
    Publication date: January 31, 2019
    Inventors: Eric PEARLMAN, Mark KESTER
  • Ceramide composition and method of use
    Patent number: 10045953
    Abstract: A method for treating and preventing diseases associated with neutrophil infiltration, particularly ocular diseases, is provided, which method comprises administering to a subject in need thereof an effective amount of ceramide or a derivative thereof. Also provided is a composition for treating diseases associated with neutrophil infiltration, the composition comprising ceramide or a derivative thereof.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: August 14, 2018
    Assignees: Case Western Reserve University, The Penn State Research Foundation
    Inventors: Eric Pearlman, Mark Kester
  • Compositions and methods of inhibiting IL-17 expression of neutrophils
    Patent number: 9814720
    Abstract: A method of inhibiting IL-17 expression in neutrophils of a subject in need thereof includes administering to neutrophils of the subject a therapeutically effective amount of agent that inhibits STAT3 mediated IL-17 expression in the neutrophils of the subject.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: November 14, 2017
    Assignee: Case Western Reserve University
    Inventor: Eric Pearlman
  • Thioredoxin protein inhibitors and uses thereof
    Patent number: 9603839
    Abstract: A method of treating a fungal infection in a subject including administering to the subject a therapeutically effective amount of a thioredoxin protein inhibitor to treat the fungal infection in the subject.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: March 28, 2017
    Assignee: Case Western Reserve University
    Inventors: Eric Pearlman, Sixto M. Leal, Jr.
  • COMPOSITIONS AND METHODS OF INHIBITING IL-17 EXPRESSION OF NEUTROPHILS
    Publication number: 20160058767
    Abstract: A method of inhibiting IL-17 expression in neutrophils of a subject in need thereof includes administering to neutrophils of the subject a therapeutically effective amount of agent that inhibits STAT3 mediated IL-17 expression in the neutrophils of the subject.
    Type: Application
    Filed: August 27, 2015
    Publication date: March 3, 2016
    Inventor: Eric Pearlman
  • FUNGAL IRON ACQUISITION INHIBITORS AND USES THEREOF
    Publication number: 20150366948
    Abstract: A method of treating a fungal infection in a subject includes topically administering to the subject a therapeutically effective amount of a fungal iron acquisition inhibitor to treat fungal infection in the subject.
    Type: Application
    Filed: January 29, 2014
    Publication date: December 24, 2015
    Inventors: Eric Pearlman, Sixto M. Leal, JR.
  • THIOREDOXIN PROTEIN INHIBITORS AND USES THEREOF
    Publication number: 20150306073
    Abstract: A method of treating a fungal infection in a subject including administering to the subject a therapeutically effective amount of a thioredoxin protein inhibitor to treat the fungal infection in the subject.
    Type: Application
    Filed: April 18, 2013
    Publication date: October 29, 2015
    Inventors: Eric Pearlman, Sixto M. Leal, JR.
  • Compositions and methods for treating corneal inflammation
    Patent number: 9006210
    Abstract: A method of treating corneal inflammation in a subject includes administering to the subject a therapeutically effective amount of a TLR4 antagonist.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: April 14, 2015
    Assignee: Case Western Reserve University
    Inventor: Eric Pearlman
  • COMPOSITIONS AND METHODS FOR TREATING CORNEAL INFLAMMATION
    Publication number: 20110105426
    Abstract: A method of treating corneal inflammation in a subject includes administering to the subject a therapeutically effective amount of a TLR4 antagonist.
    Type: Application
    Filed: June 15, 2009
    Publication date: May 5, 2011
    Inventor: Eric Pearlman
  • CERAMIDE COMPOSITION AND METHOD OF USE
    Publication number: 20080008749
    Abstract: A method for treating and preventing diseases associated with neutrophil infiltration, particularly ocular diseases, is provided, which method comprises administering to a subject in need thereof an effective amount of ceramide or a derivative thereof. Also provided is a composition for treating diseases associated with neutrophil infiltration, the composition comprising ceramide or a derivative thereof.
    Type: Application
    Filed: July 6, 2007
    Publication date: January 10, 2008
    Inventors: Eric Pearlman, Mark Kester
  • Angiogenic Onchocerca volvulus proteins and uses thereof
    Patent number: 6723322
    Abstract: The present invention provides a method for inducing angiogenesis in a tissue, by contacting the tissue with an amount of Ov-ASP effective to induce angiogenesis in the tissue. The present invention further provides a method for screening for an anti-Ov-ASP factor, by contacting a factor of interest with Ov-ASP, and assessing the ability of the factor to inhibit angiogenic activity of Ov-ASP. Additionally, the present invention provides a method for inhibiting angiogenesis in a subject.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: April 20, 2004
    Assignees: New York Blood Center, Inc., Case Western Reservei University, UAB Research Foundation
    Inventors: Sara Lustigman, Eric Pearlman, Thomas R. Unnasch