Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: An HVAC system includes an indoor heat-exchange coil disposed between a supply air duct and a return air duct. A damper is disposed in a re-circulation duct and is moveable between an open position and a closed position. A controller is configured to determine if the HVAC system is operating in a heating mode or an air-conditioning mode. Responsive to a determination that the HVAC system is operating in the air-conditioning mode, the controller is configured to determine if the variable-speed indoor circulation fan is operating at a minimum speed and if the relative humidity measured by the humidity sensor is above a pre-determined threshold. Responsive to a determination that the variable-speed indoor circulation fan is operating at the minimum speed and the relative humidity of the enclosed space is above the pre-determined threshold, the controller signals the damper to move to the open position.

Abstract: A fresh-air intake according to aspects of the disclosure includes an outer cover having a pair of side panels disposed in a generally parallel spaced relationship, a top panel coupled to, and disposed generally perpendicular to, each panel of the pair of side panels, a bottom panel disposed generally parallel to the top panel, and a front panel coupled to, and disposed generally perpendicular to, each panel of the pair of side panels and the top panel, the front panel having a window formed therein, a supply line coupled to the bottom panel, a weir extending above the bottom panel and surrounding a junction with the supply line, a baffle disposed inside the outer cover, the baffle being disposed inwardly of the window so as to prevent infiltration of moisture into the supply line, and a weep hole formed in the bottom panel.

Abstract: An HVAC system includes an evaporator coil disposed between a supply air duct and a return air duct. A re-circulation duct fluidly couples the supply air duct and the return air duct. A damper is disposed in the re-circulation duct and is moveable between an open position and a closed position. A controller is operatively coupled to a variable-speed compressor, a variable-speed circulation fan, and the damper. Responsive to a determination that the variable-speed circulation fan is operating at the minimum speed and the suction pressure is above the pre-determined threshold, the controller signals the damper to move to the open position. Responsive to a determination that the variable-speed circulation fan is not operating at the minimum speed or the suction pressure is below the pre-determined threshold, the controller signals the damper to move to the closed position.

Abstract: An HVAC system with a reheat coil is described, the system includes a compressor, a micro-channel condenser and an evaporator. A reversing valve is connected to the compressor, the micro-channel condenser and the reheat coil. The reversing valve is used to direct the refrigerant from the compressor to the micro-channel condenser in a normal mode, and to direct the refrigerant from the compressor to the reheat coil in a reheat mode. The reversing valve can be switched from normal mode to reheat mode when a high pressure condition is detected at an input to the micro-channel condenser, and switched back from reheat mode to normal mode when the high pressure condition has resolved or an amount of time has passed. In the normal mode the refrigerant is returned from the reheat coil into a refrigerant line between the evaporator and the compressor through a restrictor.

Abstract: A controller, a water source heat pump and a computer useable medium are disclosed herein. In one embodiment the controller includes: (1) an interface configured to receive operating data and monitoring data from the water source heat pump and transmit control signals to components of thereof and (2) a processor configured to respond to the operating data or the monitoring data by operating at least one motor-operated valve of the water source heat pump via a control signal.

Abstract: A burner assembly according to aspects of the disclosure includes a burner surface carried by a burner, the burner surface extending outward from a front side of the burner, a housing coupled to the burner on a side opposite the front side of the burner, a gasket disposed between the burner and the housing, a thermally anisotropic protective covering located on the front side of the burner and surrounding a perimeter of the burner surface, and an igniter positioned adjacent to the burner surface.

Abstract: A metering device may automatically control fluid flow through a valve. A control system may alter the automatic control of a metering device. In some implementations, a predetermined event may occur to alter the automatic control of the metering device.

Abstract: A burner box assembly according to aspects of the disclosure includes an outer cover, the outer cover having a sloped bottom face that directs condensation away from a heat-exchange tube, a heat-resistant liner having a plurality of panel members, the heat-resistant liner being disposed within the outer cover, a shield disposed between the heat-resistant liner and the sloped bottom face of the outer cover such that an air gap is formed between the shield and the sloped bottom face, and a tubular member abutting at least one of the plurality of panel members and disposed within the heat-exchange tube.

Abstract: A metering device may automatically control fluid flow through a valve. A control system may alter the automatic control of a metering device. In some implementations, a predetermined event may occur to alter the automatic control of the metering device.

Abstract: An HVAC system includes an indoor heat-exchange coil disposed between a supply air duct and a return air duct. A damper is disposed in a re-circulation duct and is moveable between an open position and a closed position. A controller is configured to determine if the HVAC system is operating in a heating mode or an air-conditioning mode. Responsive to a determination that the HVAC system is operating in the air-conditioning mode, the controller is configured to determine if the variable-speed indoor circulation fan is operating at a minimum speed and if the relative humidity measured by the humidity sensor is above a pre-determined threshold. Responsive to a determination that the variable-speed indoor circulation fan is operating at the minimum speed and the relative humidity of the enclosed space is above the pre-determined threshold, the controller signals the damper to move to the open position.

Abstract: An HVAC system includes an indoor heat-exchange coil disposed between a supply air duct and a return air duct. A damper is disposed in a re-circulation duct and is moveable between an open position and a closed position. A controller is configured to determine if the HVAC system is operating in a heating mode or an air-conditioning mode. Responsive to a determination that the HVAC system is operating in the air-conditioning mode, the controller is configured to determine if the variable-speed indoor circulation fan is operating at a minimum speed and if the relative humidity measured by the humidity sensor is above a pre-determined threshold. Responsive to a determination that the variable-speed indoor circulation fan is operating at the minimum speed and the relative humidity of the enclosed space is above the pre-determined threshold, the controller signals the damper to move to the open position.

Abstract: A refrigeration system is disclosed. The refrigeration system includes a refrigeration circuit including a compressor, a condenser, an expansion valve, and an evaporator fluidly connected. A purge circuit is fluidly connected to the condenser. The purge circuit is configured to receive a purge stream from the condenser. The purge stream is a mixture including a refrigerant and non-condensables. The purge circuit includes a plurality of heat exchangers for condensing the purge stream such that the non-condensables and the refrigerant in the purge stream are separated.

Abstract: A burner assembly according to aspects of the disclosure includes a burner surface carried by a burner, the burner surface extending outward from a front side of the burner, a housing coupled to the burner on a side opposite the front side of the burner, a gasket disposed between the burner and the housing, a thermally anisotropic protective covering located on the front side of the burner and surrounding a perimeter of the burner surface, and an igniter positioned adjacent to the burner surface.

Abstract: A controller, a water source heat pump and a computer useable medium are disclosed herein. In one embodiment the controller includes: (1) an interface configured to receive operating data and monitoring data from the water source heat pump and transmit control signals to components of thereof and (2) a processor configured to respond to the operating data or the monitoring data by operating at least one motor-operated valve of the water source heat pump via a control signal.

Abstract: A burner assembly according to aspects of the disclosure includes a burner surface carried by a burner, the burner surface extending outward from a front side of the burner, a housing coupled to the burner on a side opposite the front side of the burner, a gasket disposed between the burner and the housing, a thermally anisotropic protective covering located on the front side of the burner and surrounding a perimeter of the burner surface, and an igniter positioned adjacent to the burner surface.

Abstract: Purge systems for heating, ventilation, air conditioning, and refrigeration (HVACR) circuits in chillers can use adsorbent and/or membranes to separate refrigerant from non-condensable gases, allowing the non-condensables to be exhausted while the working fluid can be recovered and returned to the HVACR circuit. The purge systems can include one or more separation chambers including either an adsorbent material or a selectively permeable membrane. The selectively permeable membrane can be solubility-based for its selectivity. Optionally, a pusher pump can be upstream of the separation chambers to pressurize the purge gas through the purge system, including in the separation chamber. The purge system can be controlled using a model correlating pressure differentials in the purge system with purge gas conditions such as non-condensable and working fluid concentrations.

Abstract: A controller, a water source heat pump and a computer useable medium are disclosed herein. In one embodiment the controller includes: (1) an interface configured to receive operating data and monitoring data from the water source heat pump and transmit control signals to components of thereof and (2) a processor configured to respond to the operating data or the monitoring data by operating at least one motor-operated valve of the water source heat pump via a control signal.

Abstract: One aspect, as provided herein, is directed to a multi-stage fluid control system for a fluid source heat pump system. This embodiment comprises compressors configured to operate as separate, heat exchange stages, condensers each being fluidly coupled to at least one of the compressors by refrigerant tubing and having intake ends coupled together by a fluid intake manifold. This embodiment further includes output conduits coupled to each of the condensers and that are couplable to a distal location. Further included is a modulating valve control system interposed the output conduits. The modulating valve control system is configured to stage a flow of fluid through the condensers based on a number of operating compressors.