Abstract: An internal mechanism configured to pump a fluid in an ophthalmic device is provided. The internal mechanism includes an inlet port, a drive member coupled to the actuator and a plunger coupled to the drive member. The drive member provides a force that moves the plunger in a first direction when the actuator moves from an un-pressed position to a pressed position, the movement of the plunger in the first direction causing the fluid to move from the inlet port and through a cannula and causing a portion of the fluid to exit one or more orifices of the cannula. An ophthalmic device having an internal mechanism is also provided.

Abstract: Ophthalmic devices include a housing and a cannula extending from the housing, the cannula having a lumen for fluid flow, a reservoir for holding fluid and an activation assembly. The activation assembly includes a rotatable wheel and a moveable housing ring coupled to the wheel, the coupled rotatable wheel and moveable housing ring configured to move inward together towards an interior of the housing when an inward force is applied to the wheel and to move outward together away from the interior of the housing when an outward force is applied to the coupled wheel and the moveable housing ring. Methods of operating ophthalmic devices are also provided.

Abstract: An ophthalmic device including a cannula having a cannula distal end, a lumen, and at least one fluid outlet is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula.

Abstract: Intraocular drainage devices and methods of making intraocular drainage devices are disclosed. A disclosed intraocular drainage device includes a tube having a distal end and a body disposed proximal to the tube. A central inlet port is disposed on the distal end of the tube and extends lengthwise internally through the tube. A central outlet port is disposed on the proximal end of the body and extends lengthwise internally through the body. Multiple transverse inlet and outlet ports are coupled to the central inlet and outlet ports, respectively. The central and transverse inlet ports are configured to receive influent fluid from an anterior chamber of an eye and the central and transverse outlet ports are configured to output the influent fluid external to the anterior chamber of the eye. Intraocular drainage and core assemblies and methods of making intraocular drainage devices are also disclosed.

Abstract: An intraocular drainage device may include a monolithic silicone body having a flap, a rigid bottom plate having a portion configured to contact a corresponding portion of the flap, and a tube having a proximal end disposed between the flap and the rigid bottom plate. The corresponding portion of the flap may be configured to separate from the portion of the rigid bottom plate responsive to a fluid pressure in aqueous humor received from the tube. A plurality of parallel microgrooves may be formed on one or more portions of one or more outer surfaces of the intraocular drainage device.

Abstract: Ophthalmic devices can be applied for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The ophthalmic device can be used to cut the trabecular meshwork (TM) in the eye. The device tip provides entry into the Schlemm's canal and ramped portions elevate the TM under tension and guide it to lateral blades. An entire strip of TM can be removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.

Abstract: An ophthalmic knife for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques is provided. The ophthalmic knife includes a shaft, a first platform connected to an end of the shaft and extending at an angle from a longitudinal axis of the shaft and a second platform connected to the shaft adjacent to the first platform. The first platform includes a first top surface extending from a first tip and a first bottom surface opposing the first top surface, and the second platform includes a second top surface extending from a second tip, and a second bottom surface opposing the second top surface. The first platform severs trabecular meshwork in a human eye as the trabecular meshwork advances over the first top surface of the first platform and the second bottom surface of the second platform engages but does not sever the trabecular meshwork.

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The device is configured for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

Abstract: An ophthalmic device and methods of its use can be applied for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The ophthalmic device can be used to cut the trabecular meshwork (TM) in the eye. The device tip provides entry into the Schlemm's canal and ramped portions elevate the TM under tension and guide it to lateral blades. An entire strip of TM can be removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.

Abstract: Intraocular stents are provided. An intraocular stent (20) includes a piercing end (40) for penetration into portions of the eye without requiring a surgical incision by a separate cutting device. A first retention member (50) stabilizes the intraocular stent (20) against the anterior wall of the canal of Schlemm. A second retention member (60) stabilizes the intraocular stent within the trabecular meshwork. A fluid inlet end (73) is configured to be disposed within the anterior chamber. In use. aqueous humor fluid flows into the fluid inlet end (72) through a central lumen (70) and/or drainage tubes (80) and out into the canal of Schlemm. Stack configurations of intraocular stents and insertion devices are also provided.

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The invention relates to a multi-blade device for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

Abstract: An ophthalmic device including a cannula having a cannula distal end, a lumen, and one or more orifices coupled to the lumen is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula. The internal mechanism includes a follower fixedly coupled to the sleeve and moveable between distal and proximal positions, and a release member movable between an activated position and a release position. The release member is coupled to the actuator and configured to release a force that urges the follower from the distal position to the proximal position when the release member moves from the activated position to the release position.

Abstract: An internal mechanism configured to pump a fluid in an ophthalmic device is provided. The internal mechanism includes an inlet port, a drive member coupled to the actuator and a plunger coupled to the drive member. The drive member provides a force that moves the plunger in a first direction when the actuator moves from an un-pressed position to a pressed position, the movement of the plunger in the first direction causing the fluid to move from the inlet port and through a cannula and causing a portion of the fluid to exit one or more orifices of the cannula. An ophthalmic device having an internal mechanism is also provided.

Abstract: An ophthalmic device including a cannula having a cannula distal end, a lumen, and one or more orifices coupled to the lumen is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and is configured to pump the fluid. The internal mechanism includes an inlet port disposed on a handle proximal end, a drive member coupled to the actuator and a plunger coupled to the drive member. The ophthalmic device is configured to retain a volume of fluid and to be prevented from being re-primed after a predetermined number of actuator presses, wherein the retained volume of fluid is dispensed over an additional number of actuator pushes.

Abstract: An extraction device can include a delivery shaft having a lumen and a distal end, a first wire forming a first arc and being positionable distal to the distal end of the delivery shaft while ends of the first arc are at a distalmost end of the delivery shaft, and a second wire forming a second arc and being positionable distal to the distal end of the delivery shaft while ends of the second arc are at the distalmost end of the delivery shaft. A distalmost extent of the first wire is distal to a distalmost extent of the second wire. The first wire and the second wire are separately retractable relative to the delivery shaft.

Abstract: An ophthalmic device including a cannula having a cannula distal end, a lumen, and at least one fluid outlet is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula.

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The device is configured for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The device is configured for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

Abstract: An ophthalmic device including a cannula having a cannula distal end, a lumen, and one or more orifices coupled to the lumen is provided. The cannula is configured to deliver a fluid. A sleeve is disposed around the cannula and has a sleeve distal end. A handle is coupled to the sleeve and the cannula, the handle having an actuator. An internal mechanism is coupled to the actuator and configured to retract the sleeve relative to the cannula. The internal mechanism includes a follower fixedly coupled to the sleeve and moveable between distal and proximal positions, and a release member movable between an activated position and a release position. The release member is coupled to the actuator and configured to release a force that urges the follower from the distal position to the proximal position when the release member moves from the activated position to the release position.

Abstract: Intraocular drainage devices are provided. An intraocular drainage device includes a drainage tube that provides for increased drainage of aqueous humour from the anterior chamber of the eye. A self-clearing device is disposed within the drainage tube. The self-clearing device provides an increased fluid flow path within the drainage tube in response to clotting from the body or clogging from debris in the aqueous humour. Methods of manufacturing intraocular drainage devices and methods of inserting intraocular drainage devices into the eye are also provided.