Patents by Inventor Eric R. Moellering
Eric R. Moellering has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12385022Abstract: The invention involves the provision of recombinant algal mutants that have a genetic modification to a nucleic acid sequence encoding a trehalose biosynthetic enzyme, and/or a genetic modification to a nucleic acid encoding an RNA binding domain And in some embodiments either of these algal mutants can further have a genetic mutation to a nucleic acid sequence encoding an SGI1 polypeptide. Attenuation of one, two, or all three of these genes results in a mutant organism with increased lipid productivity. It was also discovered that one, two, three, or more genetic mutations can be accumulated or “stacked” in a particular mutant cell or organism to result in further increases in the production of lipid products. The lipid products of these mutants are useful as biofuels or for other specialty chemical products.Type: GrantFiled: December 28, 2023Date of Patent: August 12, 2025Assignee: Viridos, Inc.Inventors: Eric R. Moellering, Saheed Imam, Luke Peach, Ryan Kalb, Sarah Potts
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Patent number: 12077747Abstract: The invention provides recombinant algal organisms that have a genetic modification to a gene or nucleic acid sequence encoding an RNA binding domain. In some embodiments the genetic modification can be a functional deletion or attenuation of the gene. The genetic modification results in a mutant organism with increased lipid productivity and/or higher biomass productivity. The lipid products of these mutants can be utilized as biofuels or to manufacture other specialty products. The recombinant mutants can also, optionally, have a genetic modification to a gene encoding an SGI1 polypeptide. Methods of making and using the recombinant algal mutants and methods of producing lipids are also disclosed.Type: GrantFiled: September 9, 2021Date of Patent: September 3, 2024Assignee: Viridos, Inc.Inventors: Saheed Imam, Eric R. Moellering, Luke Peach, William F. Lambert, Jessica Weir
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Publication number: 20240247290Abstract: The invention provides recombinant algal mutants that have a genetic modification to a gene or nucleic acid sequence encoding a WD40 repeat containing protein or domain. The genetic modification of one or more nucleic acid sequences encoding a WD40 repeat containing protein or domain results in a mutant organism with increased lipid productivity and/or higher biomass productivity (as measured by total organic carbon). The genetic modification can be a gene attenuation or functional deletion. The lipid products of these mutants can be utilized as biofuels or for other specialty chemical products. Methods of making and using the recombinant algal mutants and methods of producing lipids are also disclosed.Type: ApplicationFiled: April 10, 2024Publication date: July 25, 2024Inventors: Saheed Imam, Eric R. Moellering, Luke Peach, Wiilliam F. Lambert, Kathleen Kwok
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Patent number: 11976315Abstract: The invention provides recombinant algal mutants that have a genetic modification to a gene or nucleic acid sequence encoding a WD40 repeat containing protein or domain. The genetic modification of one or more nucleic acid sequences encoding a WD40 repeat containing protein or domain results in a mutant organism with increased lipid productivity and/or higher biomass productivity (as measured by total organic carbon). The genetic modification can be a gene attenuation or functional deletion. The lipid products of these mutants can be utilized as biofuels or for other specialty chemical products. Methods of making and using the recombinant algal mutants and methods of producing lipids are also disclosed.Type: GrantFiled: November 4, 2021Date of Patent: May 7, 2024Assignee: Viridos, Inc.Inventors: Saheed Imam, Eric R. Moellering, Luke Peach, William F. Lambert, Kathleen Kwok
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Publication number: 20240124858Abstract: The invention involves the provision of recombinant algal mutants that have a genetic modification to a nucleic acid sequence encoding a trehalose biosynthetic enzyme, and/or a genetic modification to a nucleic acid encoding an RNA binding domain And in some embodiments either of these algal mutants can further have a genetic mutation to a nucleic acid sequence encoding an SGI1 polypeptide. Attenuation of one, two, or all three of these genes results in a mutant organism with increased lipid productivity. It was also discovered that one, two, three, or more genetic mutations can be accumulated or “stacked” in a particular mutant cell or organism to result in further increases in the production of lipid products. The lipid products of these mutants are useful as biofuels or for other specialty chemical products.Type: ApplicationFiled: December 28, 2023Publication date: April 18, 2024Inventors: Eric R. Moellering, Saheed Imam, Luke Peach, Ryan Kalb, Sarah Potts
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Publication number: 20240052001Abstract: Disclosed herein are mutant photosynthetic microorgnaisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.Type: ApplicationFiled: September 27, 2023Publication date: February 15, 2024Inventors: Eric R. Moellering, Nicholas Bauman, Randor R. Radakovits, Roberto Spreafico, Fedor Kuzminov, Imad Ajjawi, Saheed Imam, Andrew Schultz, Kathleen Kwok, Moena Aqui, Jennifer Nominati, John Verruto, Shaun Bailey
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Patent number: 11859218Abstract: The invention involves the provision of recombinant algal mutants that have a genetic modification to a nucleic acid sequence encoding a trehalose biosynthetic enzyme, and/or a genetic modification to a nucleic acid encoding an RNA binding domain. And in some embodiments either of these algal mutants can further have a genetic mutation to a nucleic acid sequence encoding an SGI1 polypeptide. Attenuation of one, two, or all three of these genes results in a mutant organism with increased lipid productivity. It was also discovered that one, two, three, or more genetic mutations can be accumulated or “stacked” in a particular mutant cell or organism to result in further increases in the production of lipid products. The lipid products of these mutants are useful as biofuels or for other specialty chemical products.Type: GrantFiled: December 16, 2020Date of Patent: January 2, 2024Assignee: Viridos, Inc.Inventors: Eric R. Moellering, Saheed Imam, Luke Peach, Ryan Kalb, Sarah Potts
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Patent number: 11787843Abstract: Disclosed herein are mutant photosynthetic microorganisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.Type: GrantFiled: February 17, 2021Date of Patent: October 17, 2023Assignee: Viridos, Inc.Inventors: Eric R. Moellering, Nicholas Bauman, Randor R. Radakovits, Roberto Spreafico, Fedor Kuzminov, Imad Ajjawi, Saheed Imam, Andrew Schultz, Kathleen Kwok, Moena Aqui, Jennifer Nominati, John Verruto, Shaun Bailey
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Patent number: 11332764Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.Type: GrantFiled: October 15, 2020Date of Patent: May 17, 2022Assignee: Viridos, Inc.Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
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Publication number: 20220136017Abstract: The invention provides recombinant algal mutants that have a genetic modification to a gene or nucleic acid sequence encoding a WD40 repeat containing protein or domain. The genetic modification of one or more nucleic acid sequences encoding a WD40 repeat containing protein or domain results in a mutant organism with increased lipid productivity and/or higher biomass productivity (as measured by total organic carbon). The genetic modification can be a gene attenuation or functional deletion. The lipid products of these mutants can be utilized as biofuels or for other specialty chemical products. Methods of making and using the recombinant algal mutants and methods of producing lipids are also disclosed.Type: ApplicationFiled: November 4, 2021Publication date: May 5, 2022Inventors: Saheed Imam, Eric R. Moellering, Luke Peach, William F. Lambert, Kathleen Kwok
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Publication number: 20220090002Abstract: The invention provides recombinant algal organisms that have a genetic modification to a gene or nucleic acid sequence encoding an RNA binding domain. In some embodiments the genetic modification can be a functional deletion or attenuation of the gene. The genetic modification results in a mutant organism with increased lipid productivity and/or higher biomass productivity. The lipid products of these mutants can be utilized as biofuels or to manufacture other specialty products. The recombinant mutants can also, optionally, have a genetic modification to a gene encoding an SGI1 polypeptide. Methods of making and using the recombinant algal mutants and methods of producing lipids are also disclosed.Type: ApplicationFiled: September 9, 2021Publication date: March 24, 2022Inventors: Saheed Imam, Eric R. Moellering, Luke Peach, William F. Lambert, Jessica Weir
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Patent number: 11046979Abstract: The present invention provides a mutant algal microorganism that has a mutation that causes attenuated expression of TrifuncB and/or TrifuncA and as a result produces more lipids than a control algal microorganism. The mutant algal microorganism can further include a mutation in a gene encoding a peroxisomal beta-oxidation pathway protein, such as an ACO1 or PXA1 gene, or a glyoxylate pathway protein, such as an ICL1 gene, that results in attenuated expression and further increased lipid production. Furthermore, provided herein are methods of producing lipids using the mutant algal microorganisms and methods of making the mutant microorganisms.Type: GrantFiled: July 22, 2019Date of Patent: June 29, 2021Assignee: Synthetic Genomics, Inc.Inventors: Eric R. Moellering, Tom Carlson
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Publication number: 20210188924Abstract: Disclosed herein are mutant photosynthetic microorganisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.Type: ApplicationFiled: February 17, 2021Publication date: June 24, 2021Inventors: Eric R. Moellering, Nicholas Bauman, Randor R. Radakovits, Roberto Spreafico, Fedor Kuzminov, Imad Ajjawi, Saheed Imam, Andrew Schultz, Kathleen Kwok, Moena Aqui, Jennifer Nominati, John Verruto, Shaun Bailey
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Publication number: 20210180036Abstract: The invention involves the provision of recombinant algal mutants that have a genetic modification to a nucleic acid sequence encoding a trehalose biosynthetic enzyme, and/or a genetic modification to a nucleic acid encoding an RNA binding domain. And in some embodiments either of these algal mutants can further have a genetic mutation to a nucleic acid sequence encoding an SGI1 polypeptide. Attenuation of one, two, or all three of these genes results in a mutant organism with increased lipid productivity. It was also discovered that one, two, three, or more genetic mutations can be accumulated or “stacked” in a particular mutant cell or organism to result in further increases in the production of lipid products. The lipid products of these mutants are useful as biofuels or for other specialty chemical products.Type: ApplicationFiled: December 16, 2020Publication date: June 17, 2021Inventors: Eric R. Moellering, Saheed Imam, Luke Peach, Ryan Kalb, Sarah Potts
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Patent number: 10968259Abstract: Disclosed herein are mutant photosynthetic microorgnaisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. Also disclosed are methods of using such mutants for producing biomass or bioproducts, and methods of screening for such mutants.Type: GrantFiled: December 29, 2017Date of Patent: April 6, 2021Assignee: Synthetic Genomics, Inc.Inventors: Eric R. Moellering, Nicholas Bauman, Randor R. Radakovits, Roberto Spreafico, Fedor Kuzminov, Imad Ajjawi, Saheed Imam, Andrew Schultz, Kathleen Kwok, Moena Aqui, Jennifer Nominati, John Verruto, Shaun Bailey
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Publication number: 20210040515Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.Type: ApplicationFiled: October 15, 2020Publication date: February 11, 2021Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
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Patent number: 10689676Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while producing biomass at levels that are at least 45% of wild type biomass productivity under nitrogen replete conditions. Particular mutants produce at least 50% as much FAME lipid as wild type while producing at least the amount of biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.Type: GrantFiled: November 2, 2016Date of Patent: June 23, 2020Assignee: Synthetic Genomics, Inc.Inventors: Imad Ajjawi, Leah Soriaga, Moena Aqui, Eric R. Moellering
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Publication number: 20200172943Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.Type: ApplicationFiled: February 13, 2020Publication date: June 4, 2020Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
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Patent number: 10563232Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.Type: GrantFiled: February 5, 2019Date of Patent: February 18, 2020Assignee: Synthetic Genomics, Inc.Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui
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Publication number: 20190233855Abstract: The present invention provides mutant microorganism that have higher lipid productivity than the wild type microorganisms from which they are derived while biomass at levels that are within approximately 50% of wild type biomass productivities under nitrogen replete conditions. Particular mutants produce at least twice as much FAME lipid as wild type while producing at least 75% of the biomass produced by wild type cells under nitrogen replete conditions. Also provided are methods of producing lipid using the mutant strains.Type: ApplicationFiled: February 5, 2019Publication date: August 1, 2019Inventors: Imad Ajjawi, Eric R. Moellering, Leah Soriaga, Moena Aqui