Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: A treatment protocol system may include oral hygiene devices. Each oral hygiene device may detect a pH level within an opening of the user/animal, perform a comparison of the pH level within the opening of the user/animal with a threshold pH level, and selectively control a pH neutralization device based upon the comparison. The treatment protocol system also may have a server to receive a plurality of treatment parameters from each oral hygiene device. The include the pH level from each oral hygiene device, a neutralization agent use level from each oral hygiene device, and a health characteristic from an associated patient for each oral hygiene device. The server may be configured to generate a pH treatment protocol for the associated patient for each oral hygiene device based upon the treatment parameters.

Abstract: Disclosed embodiments provide systems and techniques for a computerized orchestration layer that allows financial institutions to make real-time inquiries to other financial institutions when presented with a financial instrument. In some embodiments, disclosed systems and techniques may provide for processing a real-time payment at a depository bank. In some other embodiments, disclosed systems and techniques may provide for processing a real-time payment at a paying bank.

Abstract: Disclosed embodiments provide systems and techniques for a computerized orchestration layer that allows financial institutions to make real-time inquiries to other financial institutions when presented with a financial instrument. In some embodiments, disclosed systems and techniques may provide for processing a real-time payment at a depository bank. In some other embodiments, disclosed systems and techniques may provide for processing a real-time payment at a paying bank.

Abstract: An oral hygiene device may include a housing having first and second ends, the second end configured to be inserted into an opening of a user/animal, and a processor carried by the housing. The oral hygiene device may include a pH sensor carried by the housing at the second end, and a pH neutralization device carried by the housing and configured to emit neutralization agent into the opening of the user/animal. The processor may be coupled to the pH sensor and the pH neutralization device. The processor may be configured to detect a pH level within the opening of the user/animal, compare the pH level within the opening of the user/animal with a threshold pH level, and selectively control the pH neutralization device based upon the comparison.

Abstract: Fuel fill apparatus for use with fluid delivery systems are described. An example fuel fill apparatus includes a body defining a throat area adjacent an opening of the body where the opening is configured to receive a fuel cap. A fuel fill portion defines a first passageway extending at a non-perpendicular angle relative to a longitudinal axis of the opening and a vent portion defines a second passageway. The first passageway is fluidly coupled to the second passageway via the throat area and a fuel nozzle retainer is disposed within the throat area.

Abstract: Fuel fill apparatus for use with fluid delivery systems are described. An example fuel fill apparatus includes a body defining a throat area adjacent an opening of the body where the opening is configured to receive a fuel cap. A fuel fill portion defines a first passageway extending at a non-perpendicular angle relative to a longitudinal axis of the opening and a vent portion defines a second passageway. The first passageway is fluidly coupled to the second passageway via the throat area and a fuel nozzle retainer is disposed within the throat area.