Abstract: The art/drawings are the same as the original which was submitted Feb. 7, 2003. The only change is that it has been placed on white background paper and has a margin of 1? around the entire perimeter so that the drawings comply with 37CFR 1.84 and 37 CFR 1.121.

Abstract: The invention relates to kits and methods for panhandle PCR amplification of a region of DNA having an unknown nucleotide sequence, wherein the region flanks a region of a cancer-associated gene having a known nucleotide sequence in a human patient. Amplification of an unknown region flanking a known region of a cancer-associated gene permits identification of a translocation partner of the gene or identification of a replicated sequence within the gene. The invention further relates to kits useful for performing the methods of the invention, to an isolated polynucleotide, and to primers derived from such an isolated polynucleotide.

Abstract: The invention relates to kits and methods for panhandle PCR amplification of a region of DNA having an unknown nucleotide sequence, wherein the region flanks a region of a leukemia-associated gene having a known nucleotide sequence in a human patient. Amplification of an unknown region flanking a known region of a leukemia-associated gene permits identification of a translocation partner of the gene or identification of a duplicated sequence within the gene. The invention further relates to kits useful for performing the methods of the invention, to an isolated polynucleotide, and to primers derived from such an isolated polynucleotide.