Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to a ligand and may improve immunotherapy by limiting side effects associated with immunotherapy.

Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to an NKG2D ligand or PD1 ligand and may improve immunotherapy by limiting side effects associated with immunotherapy. The present disclosure also encompasses compositions and methods for recruiting cytotoxic lymphocytes to target cells using NKG2D receptor ligands or PD1 ligands. The compositions disclosed herein comprise a NKG2D receptor ligand and a targeting molecule and may improve immunotherapy by limiting side effects associated with immunotherapy.

Abstract: A bicycle rack, including a frame and a wheel tray. The wheel tray is configured to contact a wheel of the bicycle in a pair of locations spaced from one another in a circumferential direction of the wheel. A wheel clamp assembly includes a post supported by the frame. A slider clamp is supported by and movable along the post. The slider clamp comprises a tire engagement surface and is configured to apply a force to the wheel in a direction that secures the wheel within the wheel tray. A retention arrangement of the bicycle rack, or another apparatus, includes a wedge member having a first angled surface that engages a second angled surface of the support portion. The retention arrangement includes a bolt that engages a nut, which is secured to a hitch pin of the vehicle’s hitch receiver.

Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to a ligand and may improve immunotherapy by limiting side effects associated with immunotherapy.

Abstract: An assembly and method are provided for preventing exposure of personnel to an opening defined by a surface of a wind turbine. Accordingly, a hatch assembly is arranged adjacent to the opening. The hatch assembly includes a frame structure and a support structure. The frame structure includes a plurality of frame members arranged together to at least partially surrounded opening the plurality of frame members further define a passageway for receiving the support surface. The support surface is slidable between a first position and a second position. The support surface occludes the opening defined by the surface of the wind turbine when the support surface is in the first position and occludes the passageway defined by the plurality frame members when in the second position so as to prevent exposure of personnel to the opening.

Abstract: Therapeutic polypeptides, compositions thereof and methods of use thereof for activating NK cells and treating tumors are provided. The therapeutic polypeptides can include a first domain for binding NKG2D and a second domain for binding a tumor target.

Abstract: An accessory mount assembly for mounting on a supporting structure of or associated with a vehicle. The accessory mount assembly includes a first portion having a first end wall and at least one side wall, a second portion having a second end wall, and a third portion having a plate portion and at least one mounting flange offset from the plate portion. The accessory mount assembly is configured such that, in use, a portion of the supporting structure of or otherwise associated with a vehicle is received between the first end wall and the second end wall.

Abstract: Compositions and methods for treatment of autoimmune and inflammatory conditions which include Orthopox Major Histocompatibility complex (MHC) class I-like protein (OMCP) or a variant thereof.

Abstract: Systems and methods for driver presence and position detection are disclosed herein. A method can include determining whether a vehicle is in an open area or an enclosed area, determining that a key of the vehicle is no longer present inside the vehicle and an ignition of the vehicle is on, suppressing or delaying a warning message that indicates that the key of the vehicle is no longer present inside the vehicle and the vehicle is in the open area, and providing the warning message when the vehicle is in the enclosed area.

Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to an NKG2D ligand or PD1 ligand and may improve immunotherapy by limiting side effects associated with immunotherapy. The present disclosure also encompasses compositions and methods for recruiting cytotoxic lymphocytes to target cells using NKG2D receptor ligands or PD1 ligands. The compositions disclosed herein comprise a NKG2D receptor ligand and a targeting molecule and may improve immunotherapy by limiting side effects associated with immunotherapy.

Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to an NKG2D ligand or PD1 ligand and may improve immunotherapy by limiting side effects associated with immunotherapy. The present disclosure also encompasses compositions and methods for recruiting cytotoxic lymphocytes to target cells using NKG2D receptor ligands or PD1 ligands. The compositions disclosed herein comprise a NKG2D receptor ligand and a targeting molecule and may improve immunotherapy by limiting side effects associated with immunotherapy.

Abstract: An assembly and method are provided for preventing exposure of personnel to an opening defined by a surface of a wind turbine. Accordingly, a hatch assembly is arranged adjacent to the opening. The hatch assembly includes a frame structure and a support structure. The frame structure includes a plurality of frame members arranged together to at least partially surrounded opening the plurality of frame members further define a passageway for receiving the support surface. The support surface is slidable between a first position and a second position. The support surface occludes the opening defined by the surface of the wind turbine when the support surface is in the first position and occludes the passageway defined by the plurality frame members when in the second position so as to prevent exposure of personnel to the opening.

Abstract: A tower assembly for a wind turbine includes a tower and a freestanding internal tower structure assembly. The tower has a tower wall defining an inner surface and an outer surface separated by a tower wall thickness, with the inner surface defining a tower interior. The internal tower structure assembly is positioned within the tower interior. The tower structure assembly includes a plurality of stackable support structures configured to support one or more internal tower components. Further, the tower structure assembly is freestanding within the tower interior.

Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to a ligand and may improve immunotherapy by limiting side effects associated with immunotherapy.

Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to a ligand and may improve immunotherapy by limiting side effects associated with immunotherapy.

Abstract: A device for converting sign language to audible words, including one or more gesture recognition gloves having one or more sensors disposed about the fingers of the one or more gesture recognition gloves for detecting finger positions of sign language of a wearer of the one or more gesture recognition gloves; a processor for converting the detected sign language to the audible words; a memory unit for storing a library of the sign languages in communication with the processor; a power unit for powering the device; and a speaker for sounding the audible words.

Abstract: A tower assembly for a wind turbine includes a tower and a freestanding internal tower structure assembly. The tower has a tower wall defining an inner surface and an outer surface separated by a tower wall thickness, with the inner surface defining a tower interior. The internal tower structure assembly is positioned within the tower interior. The tower structure assembly includes a plurality of stackable support structures configured to support one or more internal tower components. Further, the tower structure assembly is freestanding within the tower interior.

Abstract: A host vehicle may include: motor(s), brakes, sensors, processor(s) configured to: (a) predict a target path of a target vehicle based on lane boundaries of a virtual map; (b) compare the target path to a predicted host path of the host vehicle; (c) apply the brakes based on the comparison; (d) predict the target path and the host path as shapes, each having a two-dimensional surface area; (e) determine whether the shapes intersect, and based on the determination, (f) calculate a first timespan where the target vehicle reaches the intersection, and (g) a second timespan where the host vehicle reaches the intersection.