Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: A method is disclosed for performing a search on a search interface. To that end, the method obtains a search query from a user. Further, a user selection is obtained corresponding to a user interface element from a plurality of user interface elements. The user selection is performed on a keyboard based navigation, where each of the plurality of user interface elements is associated with a corresponding URL. Further, one or more results are generated for the search query based on the received user selection and the one or more results corresponding to the search query are displayed as output.

Abstract: A system includes a solar panel unit comprising at least one solar panel connected to a respective molten salt cell, a wind motor unit comprising at least one wind motor that is powered by the solar panel unit, each wind motor having a channel, a turbine unit comprising at least one turbine, each turbine associated with a respective wind motor via the channel, the turbine unit powered by the wind motor unit, a first battery receiving and storing power generated by the turbine unit to be used by the system, a second battery receiving and storing power generated by the turbine unit for use outside of the system, and a housing that protects at least the wind motor unit and the turbine unit.

Abstract: Technologies are provided for generation of composite messages using qualifying events corresponding to respective ticketed performances and qualifying actions of a subscriber of a service platform. By analyzing qualifying events and qualifying actions jointly, the disclosed technologies supply a number of contextually-relevant individual messages collected in a composite message that is delivered to the subscriber periodically. The individual messages describe ticketed performances that are relevant to the subscriber. The composite message also provides reasons for the inclusion of the individual messages in the composite message. The individual messages can be arranged within the composite message according to a layout based on a ranking of priority scores. Each priority score conveys a level of relevancy of a ticketed performance with respect to a subscriber.

Abstract: Technologies are provided for generation of composite messages using qualifying events corresponding to respective ticketed performances and qualifying actions of a subscriber of a service platform. By analyzing qualifying events and qualifying actions jointly, the disclosed technologies supply a number of contextually-relevant individual messages collected in a composite message that is delivered to the subscriber periodically. The individual messages describe ticketed performances that are relevant to the subscriber. The composite message also provides reasons for the inclusion of the individual messages in the composite message. The individual messages can be arranged within the composite message according to a layout based on a ranking of priority scores. Each priority score conveys a level of relevancy of a ticketed performance with respect to a subscriber.