Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from genes including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.

Abstract: A central role for the gene encoding dopamine beta-hydroxylase in neuropsychiatric disorders is disclosed. Use of single nucleotide polymorphisms in the dopamine beta-hydroxylase gene for diagnosis, prediction of clinical course and treatment response, development of new treatments and development of cell-culture based and animal models for research and treatment are disclosed.

Abstract: Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression.

Abstract: Methods for diagnosing and treating neuropsychiatric disorders, especially schizophrenia, and methods for identifying compounds for use in the diagnosis and treatment of neuropsychiatric disorders are disclosed. Also disclosed are novel compounds and pharmaceutical compositions for use in the diagnosis and treatment of neuropsychiatric disorders such as schizophrenia.

Abstract: Methods for determining the amount of an RNA transcript in a test sample are disclosed, utilizing a reference sample comprising a known amount of a reference nucleic acid, labeled with a first strand 3′ cDNA primer and a first strand 5′ cDNA primer comprising a reference specificity determining box; and a test sample comprising an amount of test RNA containing an RNA transcript of interest, the test RNA being labeled with the first strand 3′ cDNA primer and a first strand 5′ cDNA primer comprising a test specificity determining box. The reference sample and the test sample are mixed and subjected to polymerase chain reaction amplification conditions, followed by division of the amplified, mixed sample and continued amplification of the divided sample to produce nucleic acids containing amplified reference nucleic acid or amplified cDNA of the test RNA, from which cRNA can be generated by in vitro transcription.

Abstract: Methods for predicting phenotypic classes of brain tumors, such as brain tumor type or treatment outcome, for brain tumor samples based on gene expression profiles are described.

Abstract: Methods for diagnosing and treating neuropsychiatric disorders, especially bipolar disorder, and to methods for identifying compounds for use in the diagnosis and treatment of neuropsychiatric disorders are disclosed. Also disclosed are novel compounds and pharmaceutical compositions for use in the diagnosis and treatment of neuropsychiatric disorders such as bipolar disorder.

Abstract: A central role for the gene encoding protein kinase C zeta in diabetes and perhaps in related disorders is disclosed. Use of single nucleotide polymorphisms in the protein kinase C zeta gene for diagnosis, prediction of clinical course and treatment response, development of new treatments and development of cell-culture based and animal models for research and treatment are disclosed.

Abstract: The present invention relates to methods and apparatus for grouping or clustering gene expression patterns from a plurality of genes. The invention utilizes a Self Organizing Map to cluster the gene expression patterns into groups that exhibit similar patterns. The clustering enables one to easily analyze gene expression data from potentially thousands of genes.

Abstract: The present invention relates to the discovery of a recombinant vector into which preselected DNA modifications can be readily inserted. Digestion of the vector with a dual cleavage restriction enzyme forms insertion sites which allow the directed placement of an insertion cassette comprised of a double stranded modification fragment containing a preselected sequence modification linked to a pair of single-stranded overhangs with DNA sequences complementary to the DNA sequences of the insertion sites formed in the isolated DNA of the vector. Methods of producing recombinant vectors, and methods of utilizing the vectors to create cell libraries, to identify snRNAs which suppress expression of transcription products, to suppress expression of transcription products and to deliver antisense targeting sequences are also within the scope of the invention.

Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from genes including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.

Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from genes including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.

Abstract: The identification of a subset of genes which function in metastasis of tumor cells is described. Also described are methods of diagnosis and therapy of metastatic conditions relating to the identified genes.

Abstract: The present invention provides a computer method and apparatus for detecting mutations in DNA fragments. Specifically, percent acetonitrile and threshold temperature, for use in the denaturing high performance liquid chromatography method of separating DNA fragments, are determined. In a preferred embodiment, the present invention serves as a preprocessor to the DHPLC system described in the cited art.